Treatment of lactase deficiency in children’s obesity with genotype C/C 13910 of lactase gene

Introduction: Excess lactose in the diet of modern man causes the development of not only lactase deficiency, but it can be a factor that contributes to obesity. The aim: To study associations between obesity and genotype C/C 13910 of lactase gene (LCT) in children, to investigate the effectiveness of treatment using drug exogenous lactase and a low-lactose diet. Materials and methods: genotyping of lactase gene by real-time polymerase chain reaction, determining the level of lactose maldigestion by hydrogen breath test (HBT), estimating the insulin resistance with the HOMA-IR index in 70 obese children and 40 healthy children 6 - 18 years. Obese children with genotype C/C 13910 and lactose maldigestion (n=40) were randomized in two groups: children from group I (n=20) received an exogenous lactase preparation, and children from group II (n=20) - low-lactose diet. Results: in obese children, the genotype C/C 13910 is 2 times more often than in healthy children. Obese children with genotype C/C 13910 have a significantly higher value of HBT (32.8–39.8 ppm) compared to healthy children (p<0.05), and an increased value of the HOMA-IR index. After treatment, there was a significant decrease in HBT and the HOMA-IR index in the two comparison groups. Conclusions: signs of insulin resistance are observed in children with obesity, genotype C/C 13910 and lactose maldigestion. The use of exogenous lactase in the therapy or the administration of a low-lactose diet cause approximately the same decrease in the HOMA-IR index

Treatment of lactase deficiency in children’s obesity with genotype C/C 13910 of lactase gene

Introduction: Excess lactose in the diet of modern man causes the development of not only lactase deficiency, but it can be a factor that contributes to obesity. The aim: To study associations between obesity and genotype C/C 13910 of lactase gene (LCT) in children, to investigate the effectiveness of treatment using drug exogenous lactase and a low-lactose diet. Materials and methods: genotyping of lactase gene by real-time polymerase chain reaction, determining the level of lactose maldigestion by hydrogen breath test (HBT), estimating the insulin resistance with the HOMA-IR index in 70 obese children and 40 healthy children 6 - 18 years. Obese children with genotype C/C 13910 and lactose maldigestion (n=40) were randomized in two groups: children from group I (n=20) received an exogenous lactase preparation, and children from group II (n=20) - low-lactose diet. Results: in obese children, the genotype C/C 13910 is 2 times more often than in healthy children. Obese children with genotype C/C 13910 have a significantly higher value of HBT (32.8–39.8 ppm) compared to healthy children (p<0.05), and an increased value of the HOMA-IR index. After treatment, there was a significant decrease in HBT and the HOMA-IR index in the two comparison groups. Conclusions: signs of insulin resistance are observed in children with obesity, genotype C/C 13910 and lactose maldigestion. The use of exogenous lactase in the therapy or the administration of a low-lactose diet cause approximately the same decrease in the HOMA-IR index

ПЕДІАТРИЧНА ОСВІТА УКРАЇНИ У ХХІ СТОРІЧЧІ: СУЧАСНІ ВИКЛИКИ ТА ПРОБЛЕМИ МАЙБУТНЬОГО

The aim of the work – to evaluate the state of development of pediatric education in Ukraine in the beginning of the 21st century, staffing of the branch in the field of pediatrics and to develop a plan of measures to overcome the crisis phenomena in pediatric health care. The main body. The article presents data on the development of pediatric education in the early 21st century after the restoration of the educational-scientific specialty “Pediatrics” in 2017. The development of up-to-date standards for the training of pediatric doctors, based on the acquisition of future master’s degrees in pediatrics, general and professional competencies and necessary practical skills is highlighted. The current problems in the provision of pediatric health care facilities are emphasized. Conclusion. A list of measures at the sectoral and national level has been developed to restore the necessary training рediatricians for childrenʼs health care of the country and to ensure the proper methodological provision of the educational process, which may cause difficulties in providing children with quality medical care in the future.Мета роботи – оцінити стан розвитку педіатричної освіти в Україні на початку ХХІ сторіччя, кадрове забезпечення галузі за спеціальністю «Педіатрія» та розробити план заходів щодо подолання кризових явищ у педіатричній охороні здоровʼя. Основна частина. У статті наведено дані щодо розвитку педіатричної освіти на початку ХХІ сторіччя після відновлення освітньо-наукової спеціальності «Педіатрія» у 2017 р. Висвітлено розробку сучасних стандартів підготовки дитячих лікарів, що базуються на набутті майбутніми магістрами педіатрії загальних та фахових компетенцій і необхідних практичних навичок. Наголошено на теперішніх проблемах у кадровому забезпеченні педіатричних закладів охорони здоровʼя, що може викликати складнощі у забезпеченні дітей якісною медичною допомогою у майбутньому. Висновок. Розроблений перелік заходів на галузевому та загальнодержавному рівні щодо відновлення необхідних для країни обсягів підготовки дитячих лікарів та забезпечення належного методичного забезпечення навчального процесу

APPLICATON OF MICROSEISMIC NOISE ESTIMATION IN OIL AND GAS EXPLORATION AIMED AT REDUCING ENVIRONMENTAL IMPACT

Aim. This article discusses the possibility of reducing ecological costs and risks during exploration of oil and gas fields. To this end, we propose to reduce the number of exploratory drilling works performed using unjustified non‐productive wells. Such a problem can be solved with the help of innovative seismic‐acoustic methods of direct deposit exploration.Methods. The method of microseismic noise estimation (MNE) in application to hidden hydrocarbon de‐ posits is proposed. When implementing the MNE algorithms, Chebyshev spectroscopy and analysis of the noise in terms of Gaussian distribution were used.Results. The hardware im‐ plementation of the MNE method is presented. The key component of the hardware complex is presented by an autonomous microprocessor 3D seismic module. The seismic module registers signals across the frequency range of 0.5‐40 Hz with a level of spectral density of self‐noise not higher than 0.5 nm×Hz‐1/2. Presented both in land and sea design, the module is compact and mobile.Conclusion. The application of the MNE method in prospecting and exploration allows identification and exclusion of obviously non‐productive wells from drilling, as well as reduc‐ tion of the total number of wells more than by twofold. For the Caspian region, this indicator is expected to be higher. As a result, the method will provide a significant reduction in the envi‐ ronmental consequences of the oil and gas industry as a whole

APPLICATON OF MICROSEISMIC NOISE ESTIMATION IN OIL AND GAS EXPLORATION AIMED AT REDUCING ENVIRONMENTAL IMPACT

Aim. This article discusses the possibility of reducing ecological costs and risks during exploration of oil and gas fields. To this end, we propose to reduce the number of exploratory drilling works performed using unjustified non‐productive wells. Such a problem can be solved with the help of innovative seismic‐acoustic methods of direct deposit exploration.Methods. The method of microseismic noise estimation (MNE) in application to hidden hydrocarbon de‐ posits is proposed. When implementing the MNE algorithms, Chebyshev spectroscopy and analysis of the noise in terms of Gaussian distribution were used.Results. The hardware im‐ plementation of the MNE method is presented. The key component of the hardware complex is presented by an autonomous microprocessor 3D seismic module. The seismic module registers signals across the frequency range of 0.5‐40 Hz with a level of spectral density of self‐noise not higher than 0.5 nm×Hz‐1/2. Presented both in land and sea design, the module is compact and mobile.Conclusion. The application of the MNE method in prospecting and exploration allows identification and exclusion of obviously non‐productive wells from drilling, as well as reduc‐ tion of the total number of wells more than by twofold. For the Caspian region, this indicator is expected to be higher. As a result, the method will provide a significant reduction in the envi‐ ronmental consequences of the oil and gas industry as a whole.   </jats:p

TREATMENT OF LACTASE DEFICIENCY IN CHILDREN’S OBESITY WITH GENOTYPE C/C 13910 OF LACTASE GENE

Introduction: Excess lactose in the diet of modern man causes the development of not only lactase deficiency, but it can be a factor that contributes to obesity. The aim: To study associations between obesity and genotype C/C 13910 of lactase gene (LCT) in children, to investigate the effectiveness of treatment using drug exogenous lactase and a low-lactose diet. Materials and methods: genotyping of lactase gene by real-time polymerase chain reaction, determining the level of lactose maldigestion by hydrogen breath test (HBT), estimating the insulin resistance with the HOMA-IR index in 70 obese children and 40 healthy children 6 - 18 years. Obese children with genotype C/C 13910 and lactose maldigestion (n=40) were randomized in two groups: children from group I (n=20) received an exogenous lactase preparation, and children from group II (n=20) - low-lactose diet. Results: in obese children, the genotype C/C 13910 is 2 times more often than in healthy children. Obese children with genotype C/C 13910 have a significantly higher value of HBT (32.8–39.8 ppm) compared to healthy children (p&lt;0.05), and an increased value of the HOMA-IR index. After treatment, there was a significant decrease in HBT and the HOMA-IR index in the two comparison groups. Conclusions: signs of insulin resistance are observed in children with obesity, genotype C/C 13910 and lactose maldigestion. The use of exogenous lactase in the therapy or the administration of a low-lactose diet cause approximately the same decrease in the HOMA-IR index.</jats:p