Agroclimatic Zonning of Nigeria Based on Rainfall Characteristics and Index of Drought Proneness

Nigeria, a country in sub-Saharan West Africa that depends largely on rainfall distribution for its agricultural practices has been categorised into three major climatic zones based on its rainfall characteristics and drought-proneness analysis. The data used comprises of daily rainfall of thirty years (1983 to 2012) for the thirty-eight climatic stations spread over the country. Rainfall characteristics such as onset dates, cessation dates, length of rainy season and rainfall amount within the seasons for thirty years were extracted over each of these stations for the analysis. Rainfall distribution during the rainy season was also investigated by using two-state Markov chain analysis of order one and two. The result is useful in making some pre-sowing decisions such as site selection for a particular crop and specie selection for a particular zone. The first zone has earliest rainfall onset dates, latest cessation dates and hence, having longest length of rainy season in the country. It also has the highest (lowest) Markovian probability of a wet (dry) week after a previously wet week and hence least prone to drought occurrence. Therefore, this zone is tagged “rain-forest” (Guinea). Followed closely is the zone II which is the “Savannah” and lies on the north of the zone I. On the northern part of zone II is the zone III with the shortest length of rainy season termed “Sahel”. Despite the fact that Sahel zone has the latest onset, earliest cessation and hence shortest length of rainy season, it is most prone to drought occurrence, while Savana has moderate values between those of zones I and III. Keywords: Rainfall onset, rainfall cessation, length of rainy season, drought-proneness, zones

Pharmacokinetics and clinical evaluations of gentamicin-induced nephrotoxicity in puppies

Background: The study was aimed at investigating the effect of dosing intervals on gentamicin nephrotoxicity in puppies.Methods: Local puppies were assigned to Groups A and B (n=6) and administered gentamicin intramuscularly once (6 mg/kg) or twice (3 mg/kg) daily, respectively, for 5 consecutive days. Biochemical parameters such as urine protein, creatinine, ɤ-glutamyl transferase, as well as serum creatinine (SCR) and urea nitrogen were determined spectrophotometrically using specific kits before and after treatment. Peak and trough serum concentrations of gentamicin were determined by immunoassay on 1st and 5th day treatment. Thereafter, elimination rate constants and corresponding half-lives were calculated.Results: No significant increase in SCR concentrations in both groups was observed, but values on day 7 were slightly above normal. Conversely, there was a significant increase above normal in serum urea nitrogen on days 4 and 7 in Group A, whereas this was observed only on day 7 in Group B. Even though all other biochemical parameters assayed for were within normal, an increasing trend was noticed as the length of treatment days increased in both groups. In both groups, peak serum concentrations of gentamicin did not differ significantly. There was a 4- and 16-fold significant increase in trough levels after the last treatment in Groups A and B, respectively. Although peak and trough concentrations increased with increasing length of treatment, all the values were well below 10 µg/ml and 2 µg/ml, respectively, as required.Conclusion: These suggest the risk of nephrotoxicity following treatment with gentamicin beyond 5 consecutive days irrespective of the dosing interval in puppies

Rainfall Variability and Trend Analysis over Lokoja, Nigeria

Studies on rainfall variability and trends are of great importance, particularly to the nations where rainfed agriculture is predominant. This study used CRU data (CRU_TS 4.01) to examine the temporal variability of rainfall data over Lokoja. Statistical tests were employed to examine variability and trend in monthly, seasonal and annual time series. Analysis of variability showed that the rainy seasons and annual rainfall had less variability (CV 30) in some months in the rainy season (April, July and August). Standardised precipitation index showed alternation of wet and dry period conditions had been witnessed in the study area. Trend analysis showed more positive trends had been experienced from 1970 through 2010. The variability in rainfall and the increasing trend may have a tremendous effect on water resources availabilities and vulnerabilities of Lokoja

Approximation of the Cox survival regression model by MCMC Bayesian hierarchical Poisson modelling of factors associated with childhood mortality in Nigeria

The need for more pragmatic approaches to achieve sustainable development goal on childhood mortality reduction necessitated this study. Simultaneous study of the influence of where the children live and the censoring nature of children survival data is scarce. We identified the compositional and contextual factors associated with under-five (U5M) and infant (INM) mortality in Nigeria from 5 MCMC Bayesian hierarchical Poisson regression models as approximations of the Cox survival regression model. The 2018 DHS data of 33,924 under-five children were used. Life table techniques and the Mlwin 3.05 module for the analysis of hierarchical data were implemented in Stata Version 16. The overall INM rate (INMR) was 70 per 1000 livebirths compared with U5M rate (U5MR) of 131 per 1000 livebirth. The INMR was lowest in Ogun (17 per 1000 live births) and highest in Kaduna (106), Gombe (112) and Kebbi (116) while the lowest U5MR was found in Ogun (29) and highest in Jigawa (212) and Kebbi (248). The risks of INM and U5M were highest among children with none/low maternal education, multiple births, low birthweight, short birth interval, poorer households, when spouses decide on healthcare access, having a big problem getting to a healthcare facility, high community illiteracy level, and from states with a high proportion of the rural population in the fully adjusted model. Compared with the null model, 81% vs 13% and 59% vs 35% of the total variation in INM and U5M were explained by the state- and neighbourhood-level factors respectively. Infant- and under-five mortality in Nigeria is influenced by compositional and contextual factors. The Bayesian hierarchical Poisson regression model used in estimating the factors associated with childhood deaths in Nigeria fitted the survival data.Publisher PDFPeer reviewe

Repurposing of chloroquine and hydroxychloroquine for the management of COVID-19

The Coronavirus Disease-19 (COVID-19) pandemic has impacted adversely on the global health and socio-economic activities. There is currently no evidence-based anti-SARS-CoV-2 drug for COVID-19 therapy. This review highlights some pharmacological properties of chloroquine and hydroxychloroquine and prospects of repurposing them for the treatment of COVID-19. Google scholar was employed in searching relevant published journal articles (n=118) in English. The search was later narrowed down to SARS-CoV-2, pathophysiology of COVID-19, available drugs for the management of COVID-19, clinical trials on repurposing drugs for COVID-19 therapy, and the role of chloroquine and hydroxychloroquine in the treatment of COVID-19. Documented evidence revealed that chloroquine and hydroxychloroquine have antiviral and immune-modulatory properties. Their antiviral effect is due to inhibition of the spike proteins of SARS-CoV-2 from binding to the cellular transmembrane receptors, angiotensin converting enzyme-2 thereby preventing viral infections. Also, sequestration of these drugs into the lysosomes elevates lysosomal pH thus inhibiting lysosomal enzymatic functions vital for viral replication in those cells. Whereas, their immune-modulatory activity averts the inflammatory complications of COVID-19, particularly acute respiratory syndrome, by preventing cytokine storm through suppression of the production and putative release of pro-inflammatory cytokines. The adverse effects from these drugs, notably irreversible retinopathy and cardiac arrhythmia are rare but become life-threatening when they occur. These are minimal with hydroxychloroquine compared to chloroquine. Chloroquine and hydroxychloroquine could be repurposed for managing COVID-19 cases because they are already extensively used for treating acute nonresistant malaria and auto-immune diseases. Also, a viable vaccine cannot be available in the near future while there is a pressing need for treatments to lower the daily rise in morbidity and mortality associated with the disease. Nevertheless, we suggest that emphasis should be on hydroxychloroquine because of its superior antiviral effect and clinical safety

Production of Biodiesel from Soybean Oil Using Calcium Oxide and Cow Bone as Catalysts

Biodiesel was produced from the transesterification of soybean oil using calcium oxide and cow bone (an animal waste bone that contains hydroxyapatite, a calcium phosphate mineral) as heterogeneous catalysts. The soybean oil used was characterized using gas chromatography mass spectrometer (GCMS) and the cow bone catalyst produced was characterized using X-ray diffractometer (XRD) and X-ray fluorescence (XRF) spectrometer. The effects of the variation of methanol/oil mole ratio (9–15), catalyst concentration (10–20 wt/wt%) and reaction temperature (55–65 °C) on biodiesel yield during the transesterification of soybean oil with methanol was investigated. Reaction time of 3 hours and stirring rate of 500 rpm were kept constant. It was observed that the calcination of cow bone catalyst (at 800 °C) enhanced its conversion to apatite [Ca5(PO4)3OH] and increased the yield of biodiesel obtained. Biodiesel yield results revealed an optimum condition of methanol/oil mole ratio of 9, catalyst concentration of 15 wt/wt% and reaction temperature of 55 °C. Also, the results obtained showed that the performance trends of the two catalysts used were similar. And the close values of highest biodiesel yields obtained when the two heterogenous catalysts were used separately (yields of 94.8 and 92.2% using calcium oxide and calcined cow bone catalysts respectively) implies that the use of low-cost and readily available calcined cow bone catalyst is a promising alternative to CaO catalyst

ASSESSMENT OF CARBON MONOXIDE EMISSION FROM DIFFERENT BRANDS OF SPLIT AIR-CONDITIONERS

The detection and assessment of pollutants emitted from electrical appliances has become a great area of interest to environmentalists as a means of being aware of the sources which contribute to the outdoor air quality. In this study, carbon monoxide emission was assessed from the source, which was the outdoor unit of working split air-conditioners. Five (5) brands (B1, B2, B3, B4 and B5) of twenty-five (25) split airconditioners prominent in Covenant University were selected, five split airconditioners per brand. The exhaust air from the outdoor unit was monitored for one (1) hour at two (2) minute intervals using the GM8805 Benetech carbon monoxide monitor. The data obtained were analysed and the daily mean, weekly mean, monthly mean and yearly mean contributions of each brand to the ambient carbon monoxide emission were determined. The results of individual contributions to ambient carbon monoxide emission, on yearly basis, obtained were: 35376 ppm for brand 1 (B1), 57552 ppm for brand 2 (B2), 54384 ppm for brand 3 (B3), 115632 ppm brand 4 (B4) and 672144 ppm for brand 5 (B5). The air conditioner with the highest contribution to ambient carbon monoxide concentrations was B5 at 672144 ppm on a yearly basis. It was concluded that split air-conditioners also contribute emissions into ambient air

Electrochemical control of high carbon steel corrosion using rosemary oil in citric acid medium

The Inhibition efficiency of Rosemary oil (Rosmarinus officinalis) for corrosion control of high carbon steel was done in citric acid medium by weight loss method. The Rosmarinus officinalis was administered in the proportion of 0%, 0.50%, 1.00%, 1.50%, 2.00% and 2.50% concentration. This study unveiled that the inhibition efficiency performed excellently with maximum percentage of 88.3% at room temperature in 0.5M citric acid solution. This has shown the effectiveness of Rosmarinus officinalis inhibitor in corrosion analysis of high carbon steel