Estado del arte de la energía minieólica analizando diferentes controles

Existen dos topologías de aerogeneradores según el eje de giro: eje horizontal, "Horizontal Axis Wind turbines" (HAWT) y de eje vertical, "Vertical Axis Wind Turbines" (VAWT) [2]. Las turbinas HAWT son empleadas para generación de alta potencia ya que tienen una mayor eficiencia de conversión de energía [2]. Sin embargo, las VAWT se utilizan en aplicaciones de mini eólica debido a que no necesitan ser orientadas al viento predominante y tienen menor coste de instalació

Short-Term Effects of Changing Soil Management Practices on Soil Quality Indicators and Crop Yields in Greenhouses

The short-term responses of soil quality indicators are important for assessing the effects of new management practices and addressing threats to crop yields in greenhouses. The aim of this study was to assess, during three consecutive cropping seasons, the effect of a sustainable management package (CRTMP)—which includes the on-site reuse of greenhouse crop residues and tillage—in comparison with conventional management, based on fertigation only (CMP), on certain biochemical soil quality indicators and crop yields. CRTMP significantly increased (p < 0.05) the values of total organic carbon (TOC), particulate organic carbon (POC), light fraction (LF), water soluble organic carbon (WSOC), and dehydrogenase (DH) and β-glucosidase (GL) activities at a depth of 0–15 cm, as well as the mean concentration of nitrates in the soil solution. In addition, a significant Pearson’s correlation (p < 0.01) found between the indicators suggested a balanced improvement of soil biological activity and nutritional soil state. Nonetheless, the significant (p < 0.05) increases in the mean concentration of chlorides in the soil solution and electrical conductivity (p < 0.05) increased the risk of salinization, which may have affected the concentration of nitrates in the petiole sap and total production in CRTMP, which were significantly lower than in CMP. Nevertheless, the proportion of premium product was significantly higher in CRTMP, while the proportion of non-commercial production decreased

Effect of sugar beet pulp fibre fractions on growth performance, fecal digestibility and digestive physiology in rabbits around weaning

The present study investigated the effect of the different fibre components of sugar beet pulp (SBP) on growth performance and some digestive traits. Four semi-synthetic diets were formulated with similar NDF (33% DM) and protein (16% DM) level. Control diet was formulated to contain the lowest level of soluble fibre (3% DM) and SBP diet the highest (9%). The soluble (pectins) and insoluble fractions of SBP were studied in other two diets (Pectin and InsSBP diets). A total of 136 weanling rabbits (25 d of age) was housed individually, randomly assigned to 4 experimental groups, and fed ad libitum with the experimental diets during 10 days after weaning. The type of diet did not affect growth rate and stomach pH. Animals fed with SBP diet showed higher DM and NDF digestibility (4 and 83%, respectively), gain:feed ratio (13%), cecal and total tract weight (13 and 9%) and ileal viscosity (148%) than rabbits fed the Control diet, but lower cecal pH (9%). Pectin diet increased ileal viscosity and decreased the weight of stomach content with respect to SBP diet. Rabbits fed InsSBP diet showed similar results to SBP diet but lower ileal viscosity and cecal pH than those fed Pectin diet. In conclusion, SBP and their soluble and insoluble fractions are well digested in young rabbits. However the soluble and insoluble fibre of SBP produce different effects in the gastrointestinal tract

Las mesas técnicas favorecen el diseño del plan curricular para la carrera técnico profesional de producción musical en un instituto de educación superior de Lima, período 2018-2019

El presente estudio tiene como objetivo constatar cómo es que las mesas técnicas favorecen el diseño del nuevo plan curricular de la carrera técnico profesional de Producción Musical, que ofrece un Instituto de Educación Superior de Lima, durante los períodos académicos 2018 y 2019; y de conformidad con lo dispuesto por el marco legal de la Reforma de la Educación Superior que viene promoviendo el Estado Peruano. Para este efecto, se conformaron tres mesas técnicas, integradas cada una por ocho especialistas y profesionales reconocidos del rubro de la música, así como por expertos que se desempeñan de manera exitosa en diferentes campos de la música. La metodología empleada desarrolla el enfoque cualitativo, el alcance descriptivo, y el diseño investigación - acción. Los resultados obtenidos muestran que las mesas técnicas conformadas, permitieron viabilizar y diseñar un nuevo plan curricular para la carrera técnico profesional de Producción Musical del Instituto de Educación Superior de Lima objeto de esta investigación. Se concluye que el nuevo plan curricular fue diseñado exitosamente, lo que está permitiendo una mejor formación y preparación para aquellos que deciden estudiar la carrera antes indicada, a fin de que puedan desempeñarse exitosamente en el mercado laboral una vez graduados.The objective of this study is to verify how the technical tables favor the design of the new curricular plan of the professional technical career of Musical Production, which offers a Higher Education Institute of Lima, during the academic periods 2018 and 2019; and in accordance with the provisions of the legal framework of the Higher Education Reform promoted by the Peruvian State. For this purpose, three technical tables were formed, each consisting of eight specialists and recognized professionals in the field of music, as well as experts who perform successfully in different fields of music. The methodology used develops the qualitative approach, the descriptive scope, and the research-action design. The results obtained show that the conformed technical tables allowed the feasibility and design of a new curricular plan for the professional technical career of Musical Production of the Institute of Higher Education of Lima, object of this research. It is concluded that the new curricular plan was designed successfully, which is allowing a better training and preparation for those who decide to study the aforementioned career, so that they can perform successfully in the labor market once they have graduated.Trabajo de investigaciónCampus Lima Centr

New insights into cancer: MDM2 binds to the citrullinating enzyme PADI4

PADI4 is one of the human isoforms of a family of enzymes implicated in the conversion of arginine to citrulline. MDM2 is an E3 ubiquitin ligase which is crucial for down-regulation of degradation of the tumor suppressor gene p53. Given the relationship between both PADI4 and MDM2 with p53-signaling pathways, we hypothesized they may interact directly, and this interaction could be relevant in the context of cancer. Here, we showed their association in the nucleus and cytosol in several cancer cell lines. Furthermore, binding was hampered in the presence of GSK484, an enzymatic PADI4 inhibitor, suggesting that MDM2 could bind to the active site of PADI4, as confirmed by in silico experiments. In vitro and in silico studies showed that the isolated N-terminal region of MDM2, N-MDM2, interacted with PADI4, and residues Thr26, Val28, Phe91 and Lys98 were more affected by the presence of the enzyme. Moreover, the dissociation constant between N-MDM2 and PADI4 was comparable to the IC50 of GSK484 from in cellulo experiments. The interaction between MDM2 and PADI4 might imply MDM2 citrullination, with potential therapeutic relevance for improving cancer treatment, due to the generation of new antigens

Prevalence and prognosis of anxiety, insomnia, and type D personality in patients with myocardial infarction: A Spanish cohort

Background: It has been suggested that patients with myocardial infarction and non-obstructive coronary arteries (MINOCA) have more psycho-emotional disorders than patients with obstructive coronary artery disease (MICAD). The aim of this study is to compare the prevalence of anxiety, insomnia, and type D personality between MINOCA and MICAD and their impact on prognosis. Methods: Patients with myocardial infarction undergoing coronary angiography were prospectively enrolled. Psychological questionnaires were completed by each patient during admission. Results: Among a total of 533 patients, 56 had MINOCA and 477 had MICAD. There were no differences in the prevalence of anxiety and insomnia between both groups: trait anxiety median value (M) MINOCA = 18 (11–34) vs. MICAD M = 19 (12–27), p = 0.8; state anxiety MINOCA M = 19 (11–29) vs. MICAD M = 19 (12.2–26), p = 0.6; and insomnia MINOCA M = 7 (3–11) vs. MICAD M = 7 (3–12), p = 0.95. More MINOCA patients had type D personality (45.0% vs. 28.5%, p = 0.03). At 3-year follow-up, there were no differences in mortality between MINOCA and MICAD (hazard ratio [HR] 0.78, 95% confidence interval [CI] 0.28–2.17) in major adverse cerebral or cardiovascular events (MACCE) (HR 0.71, 95% CI 0.38–1.31). Scores of trait anxiety and negative affectivity were significantly associated with MACCE (HR 1.65, 95% CI [1.05–2.57]; HR 1.75, 95% CI [1.11–2.77], respectively). High insomnia levels were associated with greater mortality (HR 2.72, 95% CI [1.12–6.61]). Conclusions: Anxiety and insomnia levels were similar between patients with MINOCA and those with MICAD, whilst the prevalence of type D personality was higher in the MINOCA than in the MICAD group. Higher scores in trait anxiety, insomnia, and negative affectivity were related to a worse prognosis at 3-year follow-up