Data Security in Cloud Computing Based on Advanced Secret Sharing Key Management Scheme

Cloud computing is a globalised concept and there are no borders within the cloud. Computers used to process and store user data can be located anywhere on the globe, depending on where the capacities that are required are available in the global computer networks used for cloud computing. Because of the attaractive features of cloud computing many organizations are using cloud storage for storing their critical information. The data can be stored remotely in the cloud by the users and can be accessed using thin clients as and when required.One of the major issue in cloud today is data security in cloud computing.Storage of data in the cloud can be risky because of use of Internet by cloud based services which means less control over the stored data. One of the major concern in cloud is how do we grab all the benefits of the cloud while maintaining security controls over the organizations assets. Our aim is to propose a more reliable, decentralized light weight key management technique for cloud systems which provides more effecient data security and key management in cloud systems. Our proposed technique provides better security against byzantine failure, server colluding and data modification attacks

Antibiotic prophylaxis in cesarean sections: a tertiary care hospital based survey

Background: The objective of the study was to study the pattern of prophylactic antibiotics usage in caesarean sections in Indian settings.Methods: A cross-sectional observational study was done on women undergoing elective and emergency caesarean sections in the Department of obstetrics and gynecology who were given antibiotics according to the existing trends in the hospital.Results: Almost 72% women received prophylactic antibiotics within 30-60 minutes of skin incision while rest 28% received it before 60 minutes. In post-operative period around 80% of the women received injectable antibiotics for 48 hours, 12% for 72 hours and rest 8% received antibiotics for more than 72 hours. 90% of the patients received injections ceftriaxone 1 gm IV BD, gentamycin 80 mg IV BD metronidazole 400 mg iv TDS while 10% received injection Ampicillin 500 mg QID along with Injection Metronidazole 400 mg iv TDS and injection gentamycin 80 mg IV BD. Two percent of the cases developed wound sepsis and required change to higher antibiotics.Conclusions: In spite of recommendations by International Guidelines for single dose of prophylactic antibiotics, multiple doses are being given. There are no Indian guidelines for antibiotic prophylaxis in cesarean sections and as a result, various combinations of antibiotics are being given for variable duration leading to antibiotic resistance and increased cost of treatment

Prevalence and causes of blindness in patients coming to a tertiary eye care centre in western Uttar Pradesh

Background: Objective of the research was to study the prevalence of blindness in adult patients coming to a tertiary eye care centre in Western Uttar Pradesh and assess their causes. Methods: A cross-sectional study was conducted on adult patients coming to the outpatient department of a tertiary eye care centre over a period of 3 months and 375 patients were identified as having blindness. Complete ophthalmological examination was conducted to find out the cause for the same. Results: The prevalence of blindness was found out to be 4.096%. The major causes for blindness in adults were identified as cataract (33.06%), glaucoma (13.6%), ARMD (5.6%), diabetic retinopathy (5.06%), corneal scar/opacity/dystrophy (26.93%), amblyopia (3.2%) and trauma (2.13%). Conclusions: Knowledge of prevalence of blindness in a region is important in developing and implementing eye care services. Avoidable blindness needs to be identified and treated as soon as possible

Vitamin D and Its Relationship with the Pathways Related to Thrombosis and Various Diseases

Vitamin D known for its vital role in diverse biological function such as calcium and phosphorus homeostasis, also exert an anticoagulant effect emphasizing its essential role in the thrombosis pathogenesis. Thrombosis is the formation and propagation of a blood clot or thrombus either in the arterial or the venous system resulting in several severe complications. Various studies have also reported the association of vitamin D deficiency with the increased incidences of thromboembolism. This may be in part due to its anticoagulant effects through upregulation of thrombomodulin, an anticoagulant glycoprotein, and downregulation of Tissue Factor, a critical coagulation factor. The protective effects of vitamin D and its receptor in endothelial cells may further explain some of the reported beneficial effects of vitamin D in the prevention or treatment of cardiovascular diseases. Additionally, the immunomodulatory role of vitamin D has been observed through its ability to alter the secretion of inflammatory cytokines that can induce a procoagulant milieu by multiple pathways. Therefore, it becomes pertinent to discuss the close link between vitamin D and human health and to improve our knowledge of the molecular pathways regulated or influenced by vitamin D and its associated metabolites

EGLN1 variants influence expression and SaO2 levels to associate with high-altitude pulmonary oedema and adaptation

Abstract EGLN1 [encoding HIF (hypoxia-inducible factor)-prolyl hydroxylase 2] plays a pivotal role in the HIF pathway and has emerged as one of the most intriguing genes with respect to physiology at HA (high altitude). EGLN1, being an actual oxygen sensor, appears to have a potential role in the functional adaptation to the hypobaric hypoxic environment. In the present study, we screened 30 polymorphisms of EGLN1, evaluated its gene expression and performed association analyses. In addition, the role of allelic variants in altering TF (transcription factor)-binding sites and consequently the replacement of TFs at these loci was also investigated. The study was performed in 250 HAPE-p [HAPE (HA pulmonary oedema)-patients], 210 HAPE-f (HAPE-free controls) and 430 HLs (healthy Ladakhi highland natives). The genotypes of seven polymorphisms, rs1538664, rs479200, rs2486729, rs2790879, rs480902, rs2486736 and rs973252, differed significantly between HAPE-p and HAPE-f (P < 0.008). The genotypes AA, TT, AA, GG, CC, AA and GG of rs1538664, rs479200, rs2486729, rs2790879, rs480902, rs2486736 and rs973252, prevalent in HAPE-p, were identified as risk genotypes and their counterpart homozygotes, prevalent in HLs, were identified as protective. EGLN1 expression was up-regulated 4.56-fold in HAPE-p (P = 0.0084). The risk genotypes, their haplotypes and interacting genotypes were associated with up-regulated EGLN1 expression (P < 0.05). Similarly, regression analysis showed that the risk alleles and susceptible haplotypes were associated with decreased SaO 2 (arterial oxygen saturation) levels in the three groups. The significant inverse correlation of SaO 2 levels with PASP (pulmonary artery systolic pressure) and EGLN1 expression and the association of these polymorphisms with SaO 2 levels and EGLN1 expression contributed to uncovering the molecular mechanism underlying hypobaric hypoxic adaptation and maladaptation

Compendium of Climate-smart Agriculture Technologies and Practices

Nepal is a vulnerable country to the impacts of climate change. The adverse effects of climate change have decreased agricultural production and productivity. Therefore, technologies and strategies to develop resilience agriculture and increased agriculture productivity are urgently needed to create climate-smart technologies and help the existing technologies to adapt to climate change. This compendium presents climate-smart agriculture (CSA) technologies and interventions for enhancing food security with adaptation and mitigation as co-benefits. CSA involves smart farming practices and strategies that help develop resilience agriculture, increase crop and livestock productivity, reduce greenhouse gas emissions, and enhance food security goals. This compendium has been developed for extension workers to support up-scaling climate-smart technologies and build climate resilience villages that enhance food, nutrition, and income, mainly for marginal communities striving in marginal areas

Conceptualising the Phenomenon of Femicide as an Embodiment of Symbolic Violence

The following paper intends to employ and consider Pierre Bourdieu’s notion of Symbolic Violence as a theoretical avenue to examine and conceptualise the phenomenon of femicide. The primary goal here is to conduct a philosophical investigation into the gender-biased practice of femicide in order to eventually construct and exhibit the affinity between the generally deemed elementary-physical and the complementary-symbolic facet of this category of violence. To be precise, by categorically alluding to Bourdieu’s notion of habitus and field, the paper attempts to demonstrate how the issue of femicide is substantially embedded in the symbolic schema. I centrally argue for the importance of re-conceptualising femicide as a continuum of symbolic form of violence in order to demonstrate that femicide does not solely necessitate and imply the perceptible physical act of the killing of females, rather, it also involves symbolic connotations. I recognise and expostulate that these symbolic connotations denote the prevalence of unfair and unjust state of affairs and the fact that physical violence is an embodied manifestation of these mundane state of affairs. Towards the end, I show that if we comprehend femicide in view of both the elementary-physical and the complementary-symbolic constituents, we eventually ensue an analogue between them, thereby breaking the physical-symbolic dichotomy.Two fundamental questions that shall be addressed here are- “how can we re-conceptualise femicide by giving thematic consideration to the category of symbolic violence?” and secondly, “what does this re-conceptualisation channel about the long-established physical-symbolic dichotomy with regards to the phenomenon of femicide?

Metaphorical Engagements in Feminist Philosophy: Two Close Readings

Metaphors have been inserted by philosophers in philosophical discourses to simplify abstract and intricate concepts. The practice of using metaphor denotes its rhetorical, aesthetic, linguistic and cognitive function. In basic formulation, metaphor has also been used by philosophers as a device, strategy, method, stylist ornament and a medium of expression. In this background, the following paper intends to vindicate the intimate interaction between philosophy and metaphor, with marked emphasis on the domain of feminist philosophy. Categorically, by considering the context of feminist philosophical discourses, in this work, I explore the contributions of two influential feminist thinkers, namely, Young and Irigaray to elucidate the proposed metaphorical narrative. I suggest that these feminist philosophers ‘talk metaphorically’ beyond its ornamental or aesthetic value; beyond objectivism. To the contrary, I propose and argue that their employment of metaphor appeals to an epistemological thematic. Furthermore, I shall exhibit the close affinity between the metaphors they insert in their respective pursuits. Questions that shall be considered here are: Why metaphor matters in philosophical contexts? What does it mean to talk metaphorically in feminist philosophical scholarship? What and how do these feminist thinkers contribute to this endeavor? What is the implication of their respective contributions? Thus, I aim at uncovering and deepening the appearance, connotation and influence of metaphor in feminist scholarship

Supplemental Figures.docx

Supplemental figures for research article entitled 'Hypobaric hypoxia modulated structural characteristics of circulating cell free DNA in high altitude pulmonary edema'</p

Understanding Inflammatory Responses in the Manifestation of Prothrombotic Phenotypes

10.3389/fcell.2020.00073FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY