Lavandula stoechas L alleviates dementia by preventing oxidative damage of cholinergic neurons in mice brain

Purpose: To ascertain if there is any scientific evidence for the folkloric use of Lavandula stoechas as a nootropic substance for memory-related disorders.Methods: Aqueous and n-hexane fractions of methanol extract of aerial parts of L. stoechas were used to explore their anti-amnesic activity. Male albino mice weighing 25 - 30 g were organized in ten groups (G-I to G-X) and treated for seven days. On 7th and 8th day, behavioral studies were conducted using elevated plus maze, hole-board and light-dark paradigms. Furthermore, biochemical studies were performed on brain homogenates of mice.Results: Half-maximal inhibitory concentration (IC50) values for aqueous and n-hexane fractions of L. stoechas were recorded as 35.14 and 357.42 μg/mL respectively, as compared to the standard, ascorbic acid (51.39 μg/mL). Behavioral test results indicate that the aqueous fraction showed significant (p < 0.001) build-up of memory in mice, compared to n-hexane fraction. Similarly, the aqueous fraction significantly (p < 0.001) reduced the level of acetylcholinesterase and malondialdehyde as well as elevation of natural antioxidants, viz, superoxide dismutase, catalase and glutathione in brain tissues.Conclusion: The aqueous fraction of L. stoechas is a memory-enhancing agent. Its antioxidant activity prevents the loss of memory by providing defense against neurodegeneration.Keywords: Acetylcholinesterase, Elevated plus maze, Behavioral studies, Lavandula stoechas, Malondialdehyd

The Curve Of Cross Border Cartel Enforcement (Challenges and Remedies in Global Business Environment)

The purpose of this article stated that the global economic arena has taken new insights across the shore of nations.  THE new economic challenges are waiting for the anti-trust enforcers to make sure strict compliance with the antitrust laws and in addition this dissertational work highlights the incipient violations across the borders and suggests its possible legel outcoms in the near future in order to make the economic market a level playing field for any business entrants. It particularly shed light on the cross border cartels and their effects on the relevant market, additionally we have taken the global view of the legislative aspects along with their de jure appliances and improvements for the proper economic growth under the auspices of legal framework. The ramification of cross border cartel enforcement has surfaced astoundingly between 1998 to 2015, underlining the earnest and prompt action to strengthen and revisit the competition law enforcement tools and proficiency. The technological advancements and liberalization of trade has risen significant challenges which includes the enforcement of cross border cartels and mergers. The globalization of corporate activities and deregulation of business markets and numerous industrial sectors has endangered the theoretical foundation of domestic and international competition enforcement regime. The transnational anticompetitive practices like monopolization of markets, collusive price fixing, vertical restraints of trade and international cartels currently challenged the jurisdiction and policies of OECD, WTO, UNCTAD, and ICN. This frightening situation necessarily be regularized by establishing worldwide competition policy and globally admirable enforcement standard. The weaknesses of unilateral, bilateral, and multilateral compacts be re-examined in order to cope with the cross- border competition challenges efficaciously. The extraterritorial, jurisdictional, and investigative mechanisms could be enclosed with binding nature of legal structures to deter cross border antitrust violations for smooth economic growth. The EU and US actively pursuing to establish the unanimous international antitrust regime instead of discrepancies to integrate WTO and ICN being multilateral cooperation forum. Currently, US, CANADA, EU, JAPAN and CHINA across the globe become more engaged in international cartels evidence gathering and investigations. The developments in information sharing, private enforcement, follow on civil litigation, dawn raids, extraterritorial reach of enforcement watchdog is yet to be established

Lavandula stoechas (L) a Very Potent Antioxidant Attenuates Dementia in Scopolamine Induced Memory Deficit Mice

The objective of the current project was to explore the pharmacotherapeutic role of Lavandula stoechas (L) for the management of dementia. Dementia is considered a global challenge of current century seeking special attention of pharmacologists to explore its best remedies. Methanolic extract of aerial parts of L. stoechas was tested for phytochemical analysis along with free radical scavenging activity. Behavioral studies were performed on scopolamine induced amnesic mice by using elevated plus maze (EPM), light and dark test and hole board paradigms. Biochemical investigations were made after decapitating the mice. Their brains were isolated for biochemical estimation of acetylcholinesterase (AChE), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). Phytochemical study ensured the presence of total phenolic contents (285.91 ± 0.75 mg of GAE/g of extract), total flavonoids (134.06 ± 0.63 mg of RE/g of extract), total tannins (149.60 ± 0.93 mg of TAE/g of extract) and free radical scavenging activity (IC50 value = 76.73 μg/ml found by DPPH method). Behavioral studies indicated that animals of GVII showed higher inflexion ratio (0.40 ± 0.03) for EPM, spent most of time (227.17 ± 2.13 s) in dark area of light dark test and had many hole pockings (39.83 ± 1.88) for hole board paradigm. Moreover, biochemical studies revealed that methanolic extract of L. stoechas (800 mg/kg/p.o.) significantly (P < 0.001) reduced brain AChE and MDA levels while improved SOD, CAT, and GSH levels. Thus the findings suggest that L. stoechas stabilizes memory by enhancing cholinergic neurotransmission and by providing defense against oxidative stress in mice brain

IMPROVING PROJECT MANAGEMENT PLANNING AND CONTROL IN THE SERVICES OPERATION ENVIRONMENT BY USING THE 6S TECHNIQUE

In today's business land-scape, more is needed for companies to have a solid organizational system and values; they must also continuously improve their quality management systems to ensure zero accidents and complete safety. With intense competition among organizations to produce quality products, creating a positive and productive workplace for employees is a common challenge. Modern technology and the latest methods must be utilized to achieve desired goals and overcome industry challenges. One of the most modern and latest techniques available to organizations is the 6S methodology, which can help achieve industry goals. This study targets to assess the current level of project management planning and control, determine the awareness and understanding of the 6S methodology, and evaluate its impact on project management planning and control. We have chosen a questionnaire methodology for this quantitative research to examine the relationship between familiarity with the 6S methodology and its implementation in a service operating environment. This study will provide insights and recommendations on incorporating the 6S methodology into project management planning and control in a service operating environment. To ensure the successful implementation of the 6S methodology, organizations should provide adequate training and resources to their project management teams and encourage collaboration and communication among team members

Is phonophobia associated with cutaneous allodynia in migraine?

ABSTRACT Objective To determine whether phonophobia and dynamic mechanical (brush) allodynia are associated in episodic migraine (EM). Methods Adult patients with EM were prospectively recruited. A structured questionnaire was used to obtain demographic and migraine related data. Phonophobia was tested quantitatively using a real time sound processor and psychoacoustic software. Sound stimuli were pure tones at frequencies of 1000 Hz, 4000 Hz and 8000 Hz, delivered to both ears at increasing intensities, until an aversive level was reached. Allodynia was assessed by brushing the patient’s skin with a gauze pad at different areas. Patients were tested both between and during acute attacks. Sound aversion thresholds (SATs) in allodynic and non-allodynic patients were compared. Results Between attacks, SATs were lower in allodynic compared with non-allodynic patients, with an average difference of 5.7 dB (p¼0.04). During acute attacks, the corresponding average SAT difference (allodynicenon-allodynic) was 15.7 dB (p¼0.0008). There was a significant negative correlation between allodynia scores and SATs, both within and between attacks. Conclusions The results support an association between phonophobia and cutaneous allodynia in migraine