218 research outputs found
Impact du passage aux normes IFRS pour le secteur des assurances : Cas de la RĂ©Ă©valuation de lâactif de placement dâune compagnie dâassurance Tunisienne
La transition attendue du secteur des assurances en Tunisie vers les normes International Financial Reporting Standards (IFRS), annoncĂ©e depuis 2018 par le conseil national de comptabilitĂ©, nĂ©cessite la prĂ©paration dâune feuille de route pour ĂȘtre Ă la hauteur des enjeux multiples et importants non seulement au niveau du reporting mais Ă©galement sur les plans opĂ©rationnels, organisationnels et stratĂ©giques.
Ce travail vise Ă dĂ©terminer lâimpact de la rĂ©Ă©valuation de lâactif de placement selon les normes IFRS sur les rĂ©sultats dâune compagnie dâassurance tunisienne en passant dâune Ă©valuation basĂ©e sur le principe du « coĂ»t historique » Ă une Ă©valuation basĂ©e sur la « valeur Ă©conomique » des actifs. Il vise Ă©galement Ă Ă©tudier lâimpact de lâĂ©cart de rĂ©Ă©valuation « IFRS-coĂ»t historique » sur les ratios en relation avec lâactif de placement de cette compagnie. Les rĂ©sultats de la prĂ©sente Ă©tude sont dâune grande utilitĂ© pratique pour les compagnies dâassurance tunisiennes. Ils ont montrĂ© lâexistence des Ă©carts de rĂ©Ă©valuation touchant les diffĂ©rentes lignes rĂ©Ă©valuĂ©es ce qui implique principalement quâune rĂ©allocation stratĂ©gique et tactique de lâactif de placement de la compagnie devrait ĂȘtre engagĂ©e prĂ©alablement Ă la transition afin dâĂ©viter les impacts susceptibles de peser lourdement sur lâĂ©quilibre financier de la compagnie
A rapid and easy method for the DNA extraction from Cryptococcus neoformans
DNA isolation from C. neoformans is difficult due to a thick and resistant capsule. We have optimized a new and rapid DNA isolation method for Cryptococcus using a short urea treatment followed by a rapid method using a chelex resin suspension. This procedure is simpler than previously reported methods
BNO : An ontology for describing the behaviour of complex biomolecular networks
International audienceThe use of semantic technologies, such as ontologies, to describe and analyse biological systems is at the heart of systems biology. Indeed, understanding the behaviour of cells requires a large amount of context information. In this paper, we propose an ontology entitled âBiomolecular Network ontologyâ using the OWL language. The BNO ontology standardises the terminology used by biologists experts to address issues including semantic behaviour representation, reasoning and knowledge sharing. The main benefit of this proposed ontology is the ability to reason about dynamical behaviour of complex biomolecular networks over time. We demonstrate our proposed ontology with a detailed example, the bacteriophage T4 gene 32 use case
Pure dysgerminoma of the ovary: a study of 31 cases
Malignant germ cell tumors of the ovary are rare tumors characterized by their heterogeneity and occurring mostly in young women. Dysgerminoma is the most common type of these tumors. This was a retrospective study of 31 patients with pure dysgerminoma of the ovary diagnosed in Salah Azaiez institute of Tunis in Tunisia between 1970 and 2012.The median age was 22 years old. Abdominal pain was the most complaint in 45.1% of cases. An abdomino-pelvic mass was found in 83.8% of cases. Surgery was performed in all patients. The median tumoral size was 13.7 cm. Sixty four-point five percent of the patients underwent a conservative surgery. The tumor was classified stage I in 51.6% of the cases, stage II in 9.7% of the cases, stage III in 35.5% of the cases and stage IV in 3.2% of the cases. Fourteen patients received platinum-based adjuvant chemotherapy, and 10 patients had a radiotherapy. We have noticed 2 cases of recurrence and 2 cases of metastasis. Five-year and ten-year overall survival was 89.4%. Five-year disease free survival was 85.2% and ten-year disease free survival was 66.3%. Dysgerminomas of the ovary have a good prognosis. The two significant prognostic factors are the stage and the postoperative residual disease
Atividade moluscicida e larvicida das partes aéreas de Atriplex inflata contra o molusco Galba truncatula, hospedeiro intermediårio da Fasciola hepatica
Fasciolose Ă© uma parasitose generalizada que ocorre em animais de fazendas em muitos paĂses em desenvolvimento. Por esta razĂŁo, Ă© necessĂĄria a busca de novas substĂąncias contra as doenças parasitĂĄrias causadas por vermes. De fato, uma grande variedade de plantas terrestres foi objeto de testes farmacolĂłgicos e quĂmicos a fim de descobrir o seu potencial para utilização em terapĂȘutica humana. As atividades moluscicida e larvicida de Atriplex inflata foram testadas contra estĂĄgios larvĂĄrios de Galba truncatula e Fasciola hepatica infectando este caracol na TunĂsia. Testes fitoquĂmicos foram realizados com extratos a fim de estabelecer uma relação significativa com as atividades moluscicida e larvicida. A atividade moluscicida foi avaliada submetendo os caracĂłis a soluçÔes aquosas. Conforme o caso, hexano, acetato de etilo, metanol e metanol-ĂĄgua (8:2, v-v) foram utilizados como solventes de extração. Como resultado, hexano e extratos de acetato apresentaram atividades potentes de acordo com a Organização Mundial de SaĂșde, resultando em LC50 = 7,59 mg/L e 6,69 mg/L para extratos de hexano de folhas e frutos, respectivamente. Extratos de acetato de etilo resultaram em LC50 = 5,90 mg/L e 7,32 mg/L para as folhas e frutos sucessivamente. Atividades moluscicidas das substĂąncias sob a forma de pĂł foram menos potentes em caracĂłis, mas ativas de acordo com a Organização Mundial de SaĂșde. Hexano e extratos de acetato de folhas e frutos apresentaram atividade larvicida potente, com uma taxa de atraso superior a 45,50% (45,50-98,92%). Testes fitoquĂmicos mostraram que estas atividades podem ser atribuĂdas Ă presença de triterpenĂłides e/ou esterĂłis.Fasciolosis is a widespread parasitosis of farm live-stock in many developing countries. For this reason, it is necessary to search for new substances against parasitic diseases caused by flukes. Indeed, a wide variety of terrestrial plants have been subjected to chemical and pharmacological screening in order to discover their potential for human medicinal use. The molluscicidal and larvicidal activities of Atriplex inflata were tested on Galba truncatula and Fasciola hepatica larval stages infecting this snail in Tunisia. Phytochemical tests were conducted on extracts in order to establish a meaningful relationship with molluscicidal and larvicidal activities. The molluscicidal activity was evaluated by subjecting snails to sample aqueous solutions. Accordingly, hexane, ethyl acetate, methanol and methanol-water (8:2, v-v) were used as extraction solvents. As a result, hexane and ethyl acetate extracts showed potent activity, according to the World Health Organization, giving LC50 = 7.59 mg/L and 6.69 mg/L for hexane extracts of leaves and fruits, respectively. Ethyl acetate extracts gave LC50 = 5.90 mg/L and 7.32 mg/L for leaves and fruits, successively. Molluscicidal activities of powders were less potent on snails, but active according to the World Health Organization. Hexane and ethyl acetate extracts from leaves and fruits gave potent larvicidal activities with a delay rate exceeding 45.50% (45.50- 98.92%). Phytochemical tests showed that these activities may be attributed to the presence of triterpenoids and/or sterols
Chemistry of Camel Milk Proteins in Food Processing
Camel milk and its extracted protein fractions were found to provide various potential techno-functional properties which can be used in the food industry. This chapter summarizes existing knowledge on camel milk proteinâs chemistry to explain the different reactions and their control for the major processes utilized by the modern milk processing industry. The composition and chemical properties of camel milk proteins including caseins and whey proteins are investigated. The effect of processing upon denaturation, aggregation, and destabilization of milk proteins is updated. Technological consequences of thermal processing as well as techno-functional properties of camel milk proteins are also described in different techno-functional properties including foaming, emulsifying, and gelling properties. This chapter aims to improve camel milk production and consumption worldwide not only in the arid countries and the hot regions
Resectable gastric signet ring cell carcinoma: clinicopathological characteristics and survival outcomes
Background:Gastric signet ring cell carcinoma (SRCC) appears to have clinical features and survival rates particularly different from other histological types. The aim of this study was to investigate clinicopathological features and survival outcomes of SRCC and to compare them with non-signet ring cell carcinoma (NSRCC).Methods:We retrospectively studied 145 patients with non-metastatic gastric carcinoma who underwent gastrectomy in our institute from 2005 to 2015. Among them, 36 patients (9.4%) with SRCC were compared to 109 patients (90.6%) with NSRCC.Results:Patients with SRCC presented at a younger age (p=0.001) with more advanced stage III-IV disease (p=0.005) and advanced N stages with a higher rate of pN3 (p=0.0001), a higher number of invaded lymph nodes (p=0.002) and a higher rate of patients with a lymph node ratio exceeding 25% (63.9% vs 36.7, p=0.004). After a median follow up of 35.30 months, there was no significant difference in the 5 years overall (OS) survival between SRCC and NSRCC ((36.7% vs 45.7%, p=0.206).However, the 5 years progressive free survival (PFS) was significantly decreased in case of SRCC (38.7% vs 50.9%, p=0.038) with a higher rate of metastasis in (52.9% vs 29.5%, p=0.013) and peritoneal recurrence (35.3% vs 9.5%, p<0.0001). The main prognostic factors of PFS and OS in SRCC were tumoral stenosis, hypoprotidemia, tumor size, depth of invasion (p=0.001), perineural and lymphovascular invasion, the UICC stage and complete surgical resection.Conclusion:Gastric SRCC have a particular clinicopathological behavior compared to NSRCC suggesting its more aggressive character
RÎle des lysosomes des cellules duodénales et hépatiques dans le phénomÚne d'accumulation du gadolinium
Characteristics of epstein barr virus variants associated with gastric carcinoma in Southern Tunisia
<p>Abstract</p> <p>Backgroud</p> <p>EBV-associated Gastric Carcinoma (EBVaGC) has a distinct clinical features and its prevalence is variable worldwide.</p> <p>Results</p> <p>To determine the prevalence of EBVaGC in Tunisia, EBV-encoded small RNA (EBER) expression was assessed in 81 gastric carcinoma (GC) specimens. The nuclear EBER expression was detected in 12 out of 81 GC cases (14.81%) and concordance between the score range of EBER staining and the number of EBV DNA copies as estimate by QPCR is observed. On the other hand, we found that EBVaGC strongly correlated with age at diagnosis, and weakly with tumor differentiation and venous invasion.</p> <p>Furthermore, the EBVaGC specimens were subjected to determine the EBV DNA polymorphisms. Our results show a unique genetic profile of the EBV strains regarding the A and D types, the F prototype, the retention of <it>Xho</it>I restriction site and the 30 bp del-LMP1 variant. <b><it>According to our previous studies on nasopharyngeal carcinoma (NPC), we suggested that EBV strains associated to GC and NPC shared some similarities in Tunisian patients</it>.</b></p> <p>Conclusion</p> <p>The prevalence of EBVaGC is of 14.81% in the southern Tunisia and that common EBV strain are associated with both NPC and GC which are likely to differ from Asian strains. Our findings support therefore a certain geographical distribution of EBV strains which is not restricted to EBV-associated malignancies.</p
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