Problem-based Learning Method: Secondary Education 10th Grade Chemistry Course Mixtures Topic

In this research; aim was determining student achievement by comparing problem-based learning method with teacher-centered traditional method of teaching 10th grade chemistry lesson mixtures topic. Pretest-posttest control group research design is implemented. Research sample includes; two classes of (total of 48 students) an Anatolian High School student in 2014-2015 academic year. Treatment took place for 16 hours. Experiment group treated with problem-based learning method, control group was treated with teacher-centered traditional method. Data was conducted with scientific achievement scale and t-test was used to analyse data. Findings showed that there was a significant difference between two groups in favour of students treated with problem-based teaching in terms of scientific achievements in mixtures topic

Miyokart infarktüsü sonrası erken dönemde gelişen akut ciddi mitral yetersizliğinin perkütan tedavisi ve kısa literatür özeti

Transcatheter edge-to-edge repair treatment is mainly used for patients with chronic heart failure concomitant severe mitral regurgitation. However, utilization of this system in the acute seting of myocardial infarction is still limited. In this case report authors aimed to show the effectiveness of the percutaneous treatment for severe acute mitral regurgitation early after myocardial infarction.Transkateter uç uca onarım temel olarak ciddi mitral yetersizliğinin eşlik ettiği kronik kalp yeter- sizliği hastalarında kullanılmaktadır. Ancak bu sistemin miyokart infarktüsünün akut fazında kullanımı henüz sınırlıdır. Yazarlar bu olgu sunumunda miyokart infarktüsü sonrası erken dönemde gelişen akut ciddi mitral yetersizliğinde perkütan tedavinin etkinliğini göstermeyi amaçlamışlardır

Red Cell Distribution Width and Acute Complications of Diabetes

Context. Red cell distribution width (RDW) has been associated with type 2 diabetes (T2DM), however data in relation to diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar non-ketotic acidosis (HONK) remains unclear. Objective. The aim of this study was to evaluate the association between RDW, MCV, and RDW/MVC values and acute complications in T2DM. Patients and Methods. RDW was measured in 90 T2DM patients (30 DKA, 30 HONK and 30 T2DM without acute complications). Clinical variables were analyzed by One -Way ANOVA, Kruskal-Wallis and Pearson analysis with SPSS software. Diagnostic screening tests and ROC curve analysis determined the cut-off point of MCV,RDW and RDW/MCV values. Results. DKA patients had higher levels of plasma glucose (524.20 +/- 201.43mg/dL, p<0.001), HbA1c (10.73 +/- 2.29%, p<0.001), osmotic pressure (310.32 mosm/L, p<0.001), RDW (14.61 +/- 1.75g/L, p<0.01), and the RDW/MCV ratio (0.17 +/- 0.04%, p<0.01), compared to HONK patients. RDW/MCV cut-off value was 0.15 with 90% sensitivity 50% specifity these values for only MCV were 76.67%-70%, for only RDW were 76.67%-63.33% respectively. The area under curve values for the ability to reflect DKA for RDW and the RDW/MCV ratio were 0.708 and 0.766, respectively (p<0.001). Conclusions. RDW and RDW/MCV ratio were found associated with DKA and valuable in predicting DKA. However these parameters were not valuable in predicting HONK

The biocompatibility of a ginger-containing herbal toothpaste on developing zebrafiish embryos

The biocompatibility of toothpaste in an oral cavity should be approved by clinical trials. Nowadays, herbal toothpaste is increasing in popularity due to its natural ingredients. Being genetically similar to humans, zebrafish are used in potential toxicity testing. The zebrafish embryotoxicity test is a fast and straightforward method to study chemical toxicity during embryogenesis. Objective: This study aimed to evaluate if there was any biocompatibility of the toothpaste on zebrafish embryos. Methods: Adult AB strain zebrafish were used according to Institutional Animal Care and Use Committee protocols. Normally dividing, spherical embryos were exposed to herbal toothpaste with ginger (Gumgumix, Turkey) (50 mg/L) and conventional toothpaste (Signal, Expert Protection, Bulgaria) (50 mg/L) in well plates containing 20 embryos, having four replicates. Developmental effects, mortality, and hatching rates were evaluated for 72h. Results: Zebrafish embryos exposed to conventional toothpaste had a higher mortality rate than those exposed to herbal toothpaste; they hatched later and delayed in development. There was no difference between herbal toothpaste and the control group regarding mortality and hatching rates (p > 0.005). Conclusion: The herbal toothpaste showed higher biocompatibility on zebrafish embryos compared to the conventional toothpaste under the condition of this study

Paraoxonase (PON1) L55M and Q192R polymorphisms in major depressive disorder and bipolar disorder

Objective: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depressive disorder and bipolar disorder. The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depressive disorder and bipolar disorder. Methods: PON1 L55M and Q192R single nucleotide polymorphisms were analyzed in a group consisted of 100 patients with major depressive disorder, and 100 patients with bipolar disorder and 96 healthy controls. Polymorphisms were analyzed by using polymerase chain reaction. Results: There were no statistically significant differences between groups for the existence of PON1 genotypes. Additionally, there was no association between the PON1 genotypes and disease variables in both depressed and bipolar patients. Conclusions: Evaluating the different stages of patients with mood disorders and examining the connection between PON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders.Publisher's Versio

Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder

Background: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depression and bipolar disorder. Objective: The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depression and bipolar affective disorder. Methods: PON1 L55M and Q192R single nucleotide polymorphisms were analyzed in a group consisted of 100 patients with major depression, and 100 patients with bipolar affective disorder and 96 healthy controls. Polymorphisms were analyzed by using polymerase chain reaction. Results: Our findings reported no association between Q192R and L55M polymorphisms of PON1 and major depression and bipolar disorder. Additionally, there was no association between the PON1 genotypes and disease variables in both depressed and bipolar patients. Discussion: Evaluating the different stages of patients with affective disorders and and investigating the connection between PON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders.This study was supported by the Gaziosmanpasa University (project no: 2015/28). The authors would like to thank the patients and the controls for their participationPublisher's Versio

Determination of bisphenol a and phthalate levels in wastewater samples

Objective: The use of endocrine-disrupting chemicals (EDCs) such as bisphenol A (BPA) in plastics manufacturing, agriculture, livestock, and paint manufacturing increas daily. The water treated in wastewater treatment plants is used in many areas such as irrigation of parks and gardens, and reinforcement of underground water resources. However, whether the treatment process eliminates EDCs in wastewater is not exactly known, and determining this as well as the amounts of these chemicals in treated water are important in terms of protecting the environment and human health. The aim of the study was to determine BPA and phthalate concentrations in the influent and effluent flow samples obtained from wastewater treatment plants. Materials and Methods: BPA and phthalate concentrations were measured in influent and effluent flow samples using the enzyme- linked immunosorbent assay (ELISA) method. BPA and phthalate measurements were performed as competitive measurements of BPA and total phthalates in samples using specific monoclonal antibodies. Results: BPA and phthalate levels were measured respectively as 7.69 μg/L and 78.27 μg/L in the influent water samples and 3.17 μg/L and 25.56 μg/L in the effluent water samples. The concentration of BPA and phthalates in the effluent samples decreased significantly compared to the influent water samples. Conclusion: This study is believed to shed light on the importance of monitoring BPA and phthalate concentrations in wastewater treatment plants and inspections for detecting other EDCs in wastewater

The effect of different storage conditions on the migration of chemicals from polyethylene terephthalate and polycarbonate bottles to water

Objective: Polyethylene terephthalate (PET) and polycarbonate (PC) bottles have been used widely in the last years for the consumption of water and the increased use of these chemicals has raised many concerns regarding their adverse effects on health. Phthalates and bisphenol A (BPA) are the main endocrine disrupting chemicals (EDCs) that can migrate from these plastics into potable water. Materials and Methods: The concentrations of phthalate and BPA were measured in water samples that were stored in PET and PC bottles at different storage conditions. The method of ELISA was used for the determination of phthalate and BPA levels. A standard curve is obtained from the standards prepared at known concentrations of phthalate, BPA, according to their absorbance at 450 nm. The BPA levels of the samples were obtained through the calculation of the absorbance values acquired using the standard curve. Results: Different storage and heating processes applied on the samples significantly increased the levels of BPA and phthalate. One year of storage led to a statistically significant increase in phthalate levels when compared to the control group. Both BPA and phthalate levels detected in the water samples were higher than the control group depending on the storage conditions including exposure to high temperatures, sunlight and outdoor conditions. Conclusion: Our results indicate the necessity to establish the environmental conditions that must be ensured during the production, transportation and storage processes of the bottles, on a legal basis with legal regulations

Using complementary and alternative medicine in patients with breast cancer diagnosis at Afyon Kocatepe University

AMAÇ: Bu çalışmada Afyon Kocatepe Üniversitesi’nde meme kanseri nedeniyle takip edilmekte olan hastalarda tamamlayıcı ve alternatif tedavi (TAT) kullanım sıklığının ve TAT ile ilgili uygulamaların belirlenmesi ve incelenmesi amaçlanmıştır. GEREÇ VE YÖNTEM: Çalışmamıza Afyon Kocatepe Üniversitesi Tıp Fakültesi Hastanesi, Tıbbi Onkoloji Polikliniği ile Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalı’na başvuran toplam 70 meme kanserli hasta dahil edilmiştir. Hastaların sosoyodemografik özellikleri ile, kullanılan TAT yöntemlerine yönelik sorgulamayı içeren 44 soruluk bir form doldurulmuştur. BULGULAR: Ortalama yaşları 57.5 ± 11.2 yıl olan hastaların en az bir TAT yöntemi kullanma oranı %85.7 (60 kişi) olarak belirlenmiştir. TAT yöntemi olarak en çok dua etmenin (%85.7) ve bitkilerin (%30) tercih edildiği saptanmıştır. TAT yöntemi kullanan meme kanserli hastaların %55’i TAT kullanmaya kendisi karar verirken, %13.3’ü ailesinin etkisiyle TAT kullanmaya başlamış. Çalışmamızda TAT kullanan hastaların sadece %35’inin bu konuda doktoruna bilgi verdiği görülmüştür. TAT kullanan hastaların %32.9’u çok fayda gördüğünü belirtirken, bu hastaların %44.3’ü tanı aldıktan hemen sonra tedavi süreci başlamadan bu yöntemlere başvurduğunu ifade etmiştir. SONUÇ: Hastalarımızın TAT yöntemlerini sık olarak kullandıkları, çoğunlukla da dua ve bitkisel yöntemleri tercih ettikleri saptanmıştır. Ayrıca meme kanserli kadınların TAT kullanımı ile ilgili sağlık çalışanlarına bilgi vermediği, özellikle kemoterapi, radyoterapi/ hormon tedavisi devam edenlerin büyük çoğunluğunun beraberinde TAT kullandığı belirlenmiştir. Ayrıca; sağlık çalışanlarının hastaları TAT kullanma yönünden sorgulamaları, böylelikle bu yöntemlerin kullanımı ile ilgili oluşabilecek yan etkilerin önlenmesine de yardımcı olunabileceğini düşünmekteyiz.OBJECTIVE: We aimed to determine the frequency of complementary and alternative therapy (CAM) usage and CAM related applications in patients with breast cancer at Afyon Kocatepe University. MATERIAL AND METHODS: Our study included a total of 70 patients with breast cancer who applied to the Afyon Kocatepe University Medical Faculty Hospital, Medical Oncology and Physical Medicine and Rehabilitation outpatient clinics. A 44-question form including questionnaires on the sociodemographic characteristics of the patients and the CAM methods used were filled out. RESULTS: Patients with a mean age of 57.5 ± 11.2 years were assigned at least one CAM method as 85.7% (60 people). It was determined that; praying (85.7%) and plants (30%) were as the most preferred CAM method. While 55% of breast cancer patients using the CAM method decided to use oneself, 13.3% of them started to use CAM due to the influence of their family. In our study, only 35% of the patients using CAM were informed about this issue by their doctor. While 32.9% of patients using CAM indicated that they were very beneficial, 44.3% of the patients stated that they applied to these methods immediately after the diagnosis was started. CONCLUSIONS: It has been determined that our patients use CAM methods frequently, mostly they prefer prayer and herbal methods. In addition, breast cancer patients do not inform health workers about the use of CAM, especially the majority of those continuing with chemotherapy, radiotherapy / hormone therapy were using CAM together. As a result; we also think that health professionals can also interrogate patients in terms of using CAM so that they can also help prevent side effects from using these methods