Greensboro VOICES: Documenting the Civil Rights Movement in Greensboro, North Carolina

On February 1, 1960, Greensboro, North Carolina became the epicenter for the civil rights movement in the United States when four African American students from North Carolina Agricultural & Technical State College (NC A&T) entered the segregated F.W. Woolworth store in downtown Greensboro and requested to be served at the whites-only lunch counter. In the following days and months, demonstrations spread across not only North Carolina but across the South where other sit-ins were held to obtain racial equality through peaceful protests. This history is documented on the “Greensboro VOICES” Web site, http://library.uncg.edu/depts/archives/civrights/, which was created by the University Archives and the Digital Projects Office at the University of North Carolina at Greensboro (UNCG) to trace the struggle for civil rights in Greensboro and the surrounding area. “Greensboro VOICES” (an acronym for “Voicing Observation in Civil Rights and Equality Struggles”) gives voice to those in the civil rights struggle by making 142 oral history interviews as well as biographical sketches of each interviewee available to students and scholars

The Carter Women Veterans Historical Project at The University of North Carolina at Greensboro: The Oral History Segment

A class reunion was the inspiration for the Carter Women Veterans Project at the Woman?s College of the University of North Carolina, now the University of North Carolina at Greensboro (UNCG). The Class of 1950 Reunion Committee met with University Archivist Betty Carter in the 1990s to plan their upcoming 50th reunion. The meetings included discussions about their classmates who had attended Woman?s College from 1946 to 1950 on the GI Bill

Women Step Up to Serve

Discusses the role of women in World War II. During World War II, over 350,000 women from across the United Stated served in the military. More than 7,000 of these women came from North Carolina. As far back as the Revolutionary War, women had served with the military as nurses, cooks, and laundresses. However, these women were considered civilians and not military. It was not until World War I, when some women served in the U.S. Navy as “Yeomanettes,” who performed mostly clerical duties, that women were considered part of the military. In 1942 officials established the Women’s Army Auxiliary Corps (WAAC), giving women auxiliary status. Females did get military status when the army disbanded the WAAC and established the Women’s Army Corps (WAC) in July 1943. Other military branches quickly followed the army’s lead, producing the WAVES, SPARS, and WASPs. Many North Carolina women who served during World War II have shared their experiences through oral history interviews conducted for the Betty H. Carter Women Veterans Historical Project based in the University Archives & Manuscripts department at The University of North Carolina at Greensboro

Preserving Our History: The Rotary Club of Greensboro, North Carolina, Oral History Project

In the fall of 2006, Bob Cone, President of the Rotary Club of Greensboro, spoke to fellow Rotarian Patricia Sullivan, Chancellor of The University of North Carolina at Greensboro, about his growing interest in preserving the city’s history by interviewing club members. Cone asked Sullivan about the possibility of the University conducting an oral history project in collaboration with the Rotary Club. The University Archives and Manuscripts department, under the guidance of University Archivist Betty Carter, had been successful in developing similar projects, including the Women Veterans Historical Collection, which includes numerous oral histories. Soon the partnership was underway

Documenting Appalachia

“Documenting Appalachia” is a digital project produced by Appalachian State University in Boone, North Carolina. The purpose of the project is “to provide off-site access to valuable research materials related to the Appalachian region and Appalachian State University.” This project documents the history of the Appalachian region through four collections: the W. Amos Abrams Folksong Collection, the I.G. Greer Folksong Collection, the Appalachian State University Historical Photographs, and the Appalachian Ethnicity Resources. It was developed in collaboration with Appalachian State University’s Center for Appalachian Studies, Appalachian Cultural Museum and the Appalachian Journal

The Building of Jackson Library 1948-1950.

On June 5, 2010, Jackson Library celebrated sixty years of service to The University of North Carolina at Greensboro. Founding President Charles Duncan McIver once said, “A great library is the very heart of the literary life of a great institution,” — a statement even more true today than it was in the 1890s when the student population numbered several hundred. Today Jackson Library, as part of the University Libraries, serves a student population of approximately 18,000 with a collection of over a million books, more than 47,000 electronic and print journal subscriptions, over 500 electronic databases, and 640,000 federal government documents

Correcting pervasive errors in RNA crystallography through enumerative structure prediction

Three-dimensional RNA models fitted into crystallographic density maps exhibit pervasive conformational ambiguities, geometric errors and steric clashes. To address these problems, we present enumerative real-space refinement assisted by electron density under Rosetta (ERRASER), coupled to Python-based hierarchical environment for integrated 'xtallography' (PHENIX) diffraction-based refinement. On 24 data sets, ERRASER automatically corrects the majority of MolProbity-assessed errors, improves the average Rfree factor, resolves functionally important discrepancies in noncanonical structure and refines low-resolution models to better match higher-resolution models

Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats

© Copyright © 2020 Balseanu, Grigore, Pinosanu, Slevin, Hermann, Glavan and Popa-Wagner. The major aim of stroke therapies is to stimulate brain repair and to improve behavioral recuperation after cerebral ischemia. Despite remarkable advances in cell therapy for stroke, stem cell-based tissue replacement has not been achieved yet stimulating the search for alternative strategies for brain self-repair using the neurogenic zones of the brain, the dentate gyrus and the subventricular zone (SVZ). However, during aging, the potential of the hippocampus and the SVZ to generate new neuronal precursors, declines. We hypothesized that electrically stimulation of endogenous neurogenesis in aged rats could increase the odds of brain self-repair and improve behavioral recuperation after focal ischemia. Following stroke in aged animals, the rats were subjected to two sessions of electrical non-convulsive stimulation using ear-clip electrodes, at 7- and 24 days after MCAO. Animal were sacrificed after 48 days. We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze) but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit. Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the gene that were unique to ES, we noted increases in the expression of seizure related 6 homolog like which is one of the physiological substrate of the β-secretase BACE1 involved in the pathophysiology of the Alzheimer’s disease and Igfbp3 and BDNF receptor mRNAs which has been shown to have a neuroprotective effect after cerebral ischemia. However, ES was associated with a long-term down regulation of cortical gene expression after stroke in aged rats suggesting that gene expression in the peri-infarcted cortical area may not be related to electrical stimulation induced-neurogenesis in the subventricular zone and hippocampus

Optimization principles of dendritic structure

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)

Metformin, an oral insulin-sensitizing drug, is actively transported into cells by organic cation transporters (OCT) 1, 2, and 3 (encoded by SLC22A1, SLC22A2, or SLC22A3), which are tissue specifically expressed at significant levels in various organs such as liver, muscle, and kidney. Because metformin does not undergo hepatic metabolism, drug-drug interaction by inhibition of OCT transporters may be important. So far, comprehensive data on the interaction of proton pump inhibitors (PPIs) with OCTs are missing although PPIs are frequently used in metformin-treated patients. Using in silico modeling and computational analyses, we derived pharmacophore models indicating that PPIs (i.e. omeprazole, pantoprazole, lansoprazole, rabeprazole, and tenatoprazole) are potent OCT inhibitors. We then established stably transfected cell lines expressing the human uptake transporters OCT1, OCT2, or OCT3 and tested whether these PPIs inhibit OCT-mediated metformin uptake in vitro. All tested PPIs significantly inhibited metformin uptake by OCT1, OCT2, and OCT3 in a concentration-dependent manner. Half-maximal inhibitory concentration values (IC50) were in the low micromolar range (3–36 µM) and thereby in the range of IC50 values of other potent OCT drug inhibitors. Finally, we tested whether the PPIs are also transported by OCTs, but did not identify PPIs as OCT substrates. In conclusion, PPIs are potent inhibitors of the OCT-mediated metformin transport in vitro. Further studies are needed to elucidate the clinical relevance of this drug-drug interaction with potential consequences on metformin disposition and/or efficacy