Evaluation of Reconfigurable Multiple and Compact Micro-Strip Antennas for MIMO Systems

In wireless communication systems, theimprovement of data rate and quality is a priority as a result ofusers' requests. During the improvement of these prioritysituations, there will also be a number of losses in the signals. It isknown that the techniques used in large systems to solve suchproblems are not efficient in small systems like modem. Therefore,when using a smaller system such as a modem, the recommendedtechniques will have to be different. Multimode antenna designswill be an important alternative for next generation wirelesscommunication systems especially for MIMO systems due to thephysical advantages of small antenna structures. In this study,MIMO channel structure is shown and performance analysis andtheories of compact micro-strip and reconfigurable multipleantenna designs used for the development of MIMOcommunication systems are mentioned

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Assessment of ex-vivo efficacy of immunotherapeutic agents in intermediate-risk and high-risk non-muscle invasive bladder cancer

Assessment of ex-vivoefficacy of immunotherapeutic agents in intermediate-risk and high-risknon-muscle invasive bladder cancer</p

Genomic Alterations of Signaling and DNA Damage Repair Pathways in Non-muscle Invasive Bladder Cancer

The aim of the study was to demonstrate the most common genetic alterations and evaluate possible targets involving PIK3/AKT/mTOR signaling and DNA damage repair (DDR) pathways for personalized treatment in patients with NMIBC. Alterations of these pathways were observed in 89.5% and 100% of patients, respectively. Among them, BARD1 was more frequently altered in low/intermediate-risk cases, but PARP4 was more frequently affected in intermediate/high-risk patients. The possible target feasibility of BARD1 and PARP4 alterations should be evaluated for personalized treatment using PARP-inhibitors in NMIBC. It is important to detect high tumor mutation burden in patients in terms of immunotherapy.</p

Anna Karenina principle in personalized treatment of bladder cancer according to oncogram: which drug for which patient?

Aim: To evaluate the ex vivo efficacy of chemotherapy, immunotherapy and targeted agents with the oncogram method in patients with bladder cancer and determine the most appropriate personalized treatment agent using immune markers. Materials & methods: Bladder cancer tissues were obtained from each patient. After cultivation, cell cultures were divided into 12 groups for each patient and 11 drugs were administered. Cell viability and immunohistochemistry expression were examined. Results: A good response rate was determined to be a 23% viability drop. The nivolumab good response rate was slightly better in PD-L1-positive patients and the ipilimumab good response rate was slightly better in tumoral CTLA-4-positive cases. Interestingly, the cetuximab response was worse in EGFR-positive cases. Conclusion: Although good responses of drug groups after their ex vivo application by using oncogram were found to be higher than control group, this outcome differed on a per patient basis. Plain language summaryBladder cancer primary cell cultures were shown to be effective for drug sensitivity and also able to be used ex vivo in the process of determining personalized treatment. The ex vivo efficacy of 11 different agents was evaluated with oncogram in bladder cancer cell cultures obtained from patients. Together with clinicopathological features, evaluation of drug responses detected by oncogram can provide important information for pretreatment drug selection when deciding on individualized treatment. Tweetable abstractEvaluation of drug responses detected by oncogram can provide important information for pretreatment drug selection when determining individualized treatment. These results show us that the Anna Karenina principle can be adapted to bladder cancer