Invasive carcinomas of the male breast: a morphologic study of the distribution of histologic subtypes and metastatic patterns in 778 cases

The current investigation was conducted to evaluate the proportional distribution of the various histologic subtypes (including newly recognized variants) of male breast carcinomas, to determine whether any histologic subtypes occur with a frequency that is markedly discordant with the expected frequencies from published data on parallel female breast tumors. We also aimed to document the distribution of malignancies metastatic to the breast. Seven hundred fifty-nine archived cases of primary invasive carcinoma involving the male breast were retrieved and subcategorized into histologic subtypes according to contemporary criteria. Six hundred forty-three (84.7%) tumors were pure infiltrating ductal carcinoma (IDC) not otherwise specified. The most common of the remainder included papillary carcinoma with invasion in the form of IDC (n = 34), mixed IDC and mucinous carcinoma (n = 26), and pure mucinous carcinoma (n = 21). In 19 cases, metastases from other sites involved the breast, most commonly (58%) cutaneous melanoma. Invasive carcinoma of the male breast appears to display a morphologic spectrum and distribution of histologic subtypes that is comparable to those of the female breast, with some expected variation. Compared with published experience on their female counterparts, there is a two-fold increase in the frequency of invasive papillary carcinoma in the male breast. Finally, the most common tumor metastatic to the male breast in this series was cutaneous melanoma

An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis

Prostate cancer (PCa) is rated the second most common cancer and sixth leading cause of cancer deaths among men globally. Reports show that African men suffer disproportionately from PCa compared to men from other parts of the world. It is still quite difficult to accurately describe the burden of PCa in Africa due to poor cancer registration systems.We systematically reviewed the literature on prostate cancer in Africa and provided a continentwide incidence rate of PCa based on available data in the regio

Malacological survey and geospatial distribution of Indoplanor bisexutus (Deshayes, 1934) and Lymnaea natalensis (Krauss 1848) snail vectors of trematode parasites, in Abeokuta, south-western, Nigeria

Vector snails of trematode parasites are important because of their role in the transmission of parasitic diseases. However, information on the diversity and distribution of snail hosts in Abeokuta area of Ogun State is scanty. Snails were collected from 31 water bodies including streams, rivers and dams on a monthly basis for six months. The snails were identified using shell morphology and examined for cercariae shedding. Collection sites were geo-referenced. Environmental data, Normalized Difference Vegetation Index (NDVI), Land Surface Temperature (LST), rainfall and Land cover corresponding to these locations were derived from Moderate resolution Imaging Spectroradiometer (MODIS). Binary logistic regression analysis was used to create spatial maps and predictive model map for snail species distribution. A total of 87 vector snails were collected; Lymnaea natalensis 65 (74.71%) and Indoplanor bisexutus 22 (25.29%).Nine out of 22I. exutus collected shed microcercouscercariae. Infected I. exutus, intermediate snail host of Schistosoma nasale, a cattle schistosome was found in two sites. The logistic regression analysis using remotely-sensed environmental data showed that NDVI was the significant variable influencing I. exutus distribution (B = -8.460, Sig = 0.043). Geospatial distribution maps were created to show the distribution of each snail species and potential transmission sites. This study mapped the distribution of snail hosts, identified possible transmission sites and demonstrates the presence of snail hosts of certain parasites in Abeokuta area (Abeokuta South and Abeokuta North Local Government Areas), the distribution of these snail hosts should be monitored to prevent transmission of these pathogens to humans.Keywords: geospatial, vector snails, trematode, distribution, malacologica

Evaluation of Haematological parameters in pregnant Nigerian women with sickle cell anaemia

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