744 research outputs found
Strain bursts in plastically deforming Molybdenum micro- and nanopillars
Plastic deformation of micron and sub-micron scale specimens is characterized
by intermittent sequences of large strain bursts (dislocation avalanches) which
are separated by regions of near-elastic loading. In the present investigation
we perform a statistical characterization of strain bursts observed in
stress-controlled compressive deformation of monocrystalline Molybdenum
micropillars. We characterize the bursts in terms of the associated elongation
increments and peak deformation rates, and demonstrate that these quantities
follow power-law distributions that do not depend on specimen orientation or
stress rate. We also investigate the statistics of stress increments in between
the bursts, which are found to be Weibull distributed and exhibit a
characteristic size effect. We discuss our findings in view of observations of
deformation bursts in other materials, such as face-centered cubic and
hexagonal metals.Comment: 14 pages, 8 figures, submitted to Phil Ma
Proposing "b-Parity" - a New Approximate Quantum Number in Inclusive b-jet Production - as an Efficient Probe of New Flavor Physics
We consider the inclusive reaction \ell^+ \ell^- -> nb +X (n = number of
b-jets) in lepton colliders for which we propose a useful approximately
conserved quantum number b_P=(-1)^n that we call b-Parity (b_P). We make the
observation that the Standard Model (SM) is essentially b_P-even since SM
b_P-violating signals are necessarily CKM suppressed. In contrast new flavor
physics can produce b_P=-1 signals whose only significant SM background is due
to b-jet misidentification. Thus, we show that b-jet counting, which relies
primarily on b-tagging, becomes a very simple and sensitive probe of new flavor
physics (i.e., of b_P-violation).Comment: 5 pages using revtex, 2 figures embadded in the text using epsfig. As
will appear in Phys.Rev.Lett.. Considerable improvement was made in the
background calculation as compared to version 1, by including purity
parameters, QCD effects and 4-jets processe
Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
Hutchinson–Gilford progeria syndrome (HGPS) is a genetic disorder characterized by premature aging features. Cells from HGPS patients express progerin, a truncated form of Lamin A, which perturbs cellular homeostasis leading to nuclear shape alterations, genome instability, heterochromatin loss, telomere dysfunction and premature entry into cellular senescence. Recently, we reported that telomere dysfunction induces the transcription of telomeric non-coding RNAs (tncRNAs) which control the DNA damage response (DDR) at dysfunctional telomeres. Here we show that progerin-induced telomere dysfunction induces the transcription of tncRNAs. Their functional inhibition by sequence-specific telomeric antisense oligonucleotides (tASOs) prevents full DDR activation and premature cellular senescence in various HGPS cell systems, including HGPS patient fibroblasts. We also show in vivo that tASO treatment significantly enhances skin homeostasis and lifespan in a transgenic HGPS mouse model. In summary, our results demonstrate an important role for telomeric DDR activation in HGPS progeroid detrimental phenotypes in vitro and in vivo
Searching For Anomalous Couplings
The capability of current and future measurements at low and high energy
colliders to probe for the existence of anomalous, CP conserving,
dipole moment-type couplings is examined. At present, constraints
on the universality of the tau charged and neutral current interactions as well
as the shape of the energy spectrum provide the strongest
bounds on such anomalous couplings. The presence of these dipole moments are
shown to influence, e.g., the extraction of from
decays and can lead to apparent violations of CVC expectations.Comment: 24 pages, 9 figure
A Model-independent Description of New Physics effects in e+e- to t tbar
We study the potential of a future collider for the search of
anomalous gamma t t bar and Z t t bar couplings, assuming that CP-invariance
holds. This is done in a model-independent way, considering that all six
possible couplings do appear. Two experimental situations are envisaged, with
and without electron beam polarization. Observability limits in the form of
domains in the 6-dimensional parameter space are established. Illustrations for
specific constrained models are also presented and implications for new physics
searches are discussed.Comment: 26 pages and 5 figures. e-mail: [email protected]
On the Hadronic Contribution to Light-by-light Scattering in
We comment on the theoretical uncertainties involved in estimating the
hadronic effects on the light-by-light scattering contribution to the anomalous
magnetic moment of the muon, especially based on the analysis and results of T.
Kinoshita, B. Ni\v zi\'c, and Y. Okamoto, Phys.\ Rev.\ D31, 2108 (1985). From
the point of view of an effective field theory and chiral perturbation theory,
we suggest that the charged pion contribution may be better determined than has
been appreciated. However, the neutral pion contribution needs greater
theoretical insight before its magnitude can be reliably estimated.Comment: 9 pages, no figures, U. Michigan UM-TH-93-18. (Input phyzzm to
compile.) Revised version has minor changes in text. To be published in Phys.
Rev. D, Comments sectio
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Automated generation of colluding apps for experimental research
Colluding apps bypass the security measures enforced by sandboxed operating systems such as Android. App collusion can be a real threat in cloud environments as well. Research in detecting and protecting against app collusion requires a variety of colluding apps for experimentation. Presently the number of (real or manually crafted) apps available to researchers is very limited. In this paper we propose a system called Application Collusion Engine (ACE) to automatically generate combinations of colluding and non-colluding Android apps to help researchers fairly evaluate different collusion detection and protection methods. Our initial implementation includes a variety of components that enable the system to create more than 5,000 different colluding and non-colluding app sets. ACE can be extended with more functional components to create even more colluding apps. To show the usefulness of our system, we have applied different risk evaluation and collusion detection methods to the created set of colluding apps
Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion
Meningiomas are tumours derived from the arachnoid and pia mater. During embryogenesis, these membranes develop from the migrating craniofacial neural crest. We have previously demonstrated that meningiomas have characteristic features of embryonic meninges. Craniofacial neural crest derivatives are affected during normal development and migration by retinoic acid. We speculated, therefore, that meningioma cell migration and invasion would be affected in a similar way. In this study we investigated the mechanisms of invasion and migration in meningiomas and the effects of retinoic acid (RA). We found that low doses of RA inhibit in vitro invasion in meningioma cells, without affecting cell proliferation or viability. The matrix metalloproteinases MMP-2 (72 kDa gelatinase) and MMP-9 (92 kDa gelatinase), which play a key role in invasion in other tumours, are not affected by RA. RA inhibits cell migration on collagen I and fibronectin. A possible mechanism for these effects is provided by the fact that RA strongly stimulates adhesion of meningioma cells to extracellular matrix substrates. As in vitro invasion, migration and decreased adhesion to the extracellular matrix correlate with the clinical manifestation of tumour invasion, we conclude that RA induces a non-invasive phenotype in meningioma cells. © 1999 Cancer Research Campaig
Dimension-Six Terms in the Standard Model Lagrangian
When the Standard Model is considered as an effective low-energy theory,
higher dimensional interaction terms appear in the Lagrangian. Dimension-six
terms have been enumerated in the classical article by Buchmueller and Wyler
[3]. Although redundance of some of those operators has been already noted in
the literature, no updated complete list has been published to date. Here we
perform their classification once again from the outset. Assuming baryon number
conservation, we find 15 + 19 + 25 = 59 independent operators (barring flavour
structure and Hermitian conjugations), as compared to 16 + 35 + 29 = 80 in
Ref.[3]. The three summed numbers refer to operators containing 0, 2 and 4
fermion fields. If the assumption of baryon number conservation is relaxed, 4
new operators arise in the four-fermion sector.Comment: 16 pages, no figures, v3: Redundant B-violating operator remove
Anomalous Neutrino Reactions at HERA
We study the sensitivity of HERA to new physics using the helicity suppressed
reaction , where the final neutrino can be a standard
model one or a heavy neutrino. The approach is model independent and is based
on an effective lagrangian parametrization. It is shown that HERA will put
significant bounds on the scale of new physics, though, in general, these are
more modest than previously thought. If deviations from the standard model are
observed in the above processes, future colliders such as the SSC and LHC will
be able to directly probe the physics responsible for these discrepancies}Comment: 11 Pages + 2 figures is TOPDRAWER (included at the end or available
by mail). Report UCRHEP-T113 (requires the macropackage PHYZZX). A line in
the TeX file requesting an input file has been removed, it caused problem
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