Causation or Coincidence? A Case of Coexisting Spontaneous Coronary Artery Dissection and Coronary Thrombosis in a Patient with Kounis Syndrome

Kounis syndrome (KS) is a hypersensitive coronary disorder leading to acute coronary syndrome triggered by drugs, food, and environmental factors. Herein, we report a 39-year-old patient who was admitted to our clinic due to type 2 KS after oral diclofenac use. Interestingly, spontaneous coronary artery dissection was detected simultaneously on coronary angiography. Up to now, no case has been defined including the combination of these two different conditions

Optimization of the use and planning of water resources with advanced data processing methods

Canlı yaşamının devam etmesi için gerekli olan en temel maddelerden biri sudur. Gelecekte ve günümüzde nüfus artışına yanıt verebilecek temiz su kaynaklarının korunması ve geliştirilmesi, gerekliliği büyük önem arz etmektedir. Su insanoğlunun enerji ihtiyacını karşılayan ve hayatta kalmasını sağlayan en temel kaynaklardan birisidir. Mevcut su potansiyelinin tasarruflu kullanılması su ve kullanımının verimli hale getirilmesi gerekmektedir. Nehir akım hızı zaman serisi kullanılarak ileriye dönük su potansiyeli tahmini yapılabilmektedir. Akım gözlem istasyonlarında günlük ölçümler yapılmaktadır. Bu verilere dayalı olarak, matematik modellerle ve makine öğrenmesi sistemleri ile tahmin çalışmaları yürütülmektedir. Bu çalışmada inceleme bölgesi olarak seçilen Çatalca Istıranca nehrine ait günlük ve aylık ortalama akım, bölgeye ait günlük toplam yağış miktarı ve günlük ortalama hava sıcaklık değerleri göz önüne alınmıştır. İstatistiksel olarak 2004-2020 inceleme dönemine ait, günlük ortalama akım 2.97 m3/s, günlük toplam yağış 2.73 (mm=kg/m2) ve ortalama hava sıcaklığı değeri 12.57 °C olarak saptanmıştır. Makine öğrenme yöntemlerinden Lineer Regresyon, Destek Vektör, Karar Ağacı, Rasgele Orman, Ekstra Ağaçlar, Dalgacık yöntemleri kullanarak akarsu akış miktarının zamanla değişimi tahmin edilmiştir. Uygulanan modellerin başarı performansları karşılaştırılmış, akış miktarı tahmininde Ekstra Ağaçlar (%90.48) ve Rasgele Orman (%88.96) diğer yöntemlere göre daha başarılı bulunmuştur.One of the most basic substances necessary for the continuation of life is water. The necessity of protecting and developing clean water resources that can respond to population growth in the future and today is of great importance. Water is one of the most basic resources that meet the energy needs of human beings and ensure their survival. It is necessary to use the existing water potential economically and to make water and its use efficient. Forward estimation can be made using the time series of river flow rates. Measurements are made daily at flow observation stations. With the data we get from here, we can make predictions with mathematical models and today's machine learning systems. Regression analysis is one of the methods used. In this study, the daily and monthly flow rate, precipitation and air temperature values of the Çatalca-Istıranca River, which was selected as the study area we determined, were taken into account. Statistically, the daily average flow 2.97 m3 /s, daily total precipitation 2.73 (mm=kg/m2 ) and average air temperature value for the 2004-2020 review period has been determined as 12.57 °C. The variation of stream flow over time was estimated by using the machine learning methods Linear Regression, Support Vector, Decision Tree, Random Forest, Extra Trees and Wavelet methods. The success performances of the applied models were compared, and the success ratio of the Extra Trees (90.48%) and Random Forest (88.96%) methods were found to be higher than the other methods in estimating the flow rate

Estimated genetic diversity between Atak-S and isa brown chickens with SSR markers

Ankara Tavukçuluk Araştırma Enstitüsü tarafından geliştirilen Atak-S yumurtacı hibriti yerli hibritler içinde yumurta verimi en yüksek olan hibrittir. Ancak bu hibritin yumurta verimi Isa Brown gibi yabancı kaynaklı hibritlere göre daha düşüktür. Atak-S hibritinin yabancı kaynaklı hibritlerle yarışabilmesi için verim ile ilgili moleküler ıslah çalışmaları gerekmektedir. Bu çalışmanın amacı Atak-S ve Isa Brown tavuk hibritlerindeki genetik çeşitliliği belirlemek ve bu hibritler arasındaki genetik çeşitliliği karşılaştırmaktır. Bu amaç için, iki alt popülasyondan 200 tavukta 6 mikrosatelit lokusu ayrı ayrı genotiplendirildi. Bu çalışmada kullanılan 6 farklı SSR markörü için toplam da 85 polimorfik fragment bulundu. Ayrıca He değeri 0.61±0.05 olarak bulundu. İki hibrit arasında He ise; Atak-S’de 0.35±0.76, Isa Brown’da 0.26±0.68 olarak bulundu. Bu sonuç, Atak-S hibritindeki genetik çeşitliliğin Isa Brown hibritine göre daha yüksek olduğunu ortaya koymuştur. Ek olarak iki hibrite ait genetik farklılıklar ve popülasyon yapısı dendogram analizi yapılarak ortaya konmuş ve farklıllıklar belirlenmiştir. Sonuç olarak Atak-S ve Isa Brown hibritleri içindeki ve arasında genetik çeşitliliklerin iyi korunmuş olduğu ileri sürülebilir. Mikrosatellit analizi ile tahmin edilen Atak-S ve Isa Brown hibrtileri hakkındaki bilgiler, gelecekteki genetik varyasyon araştırmalarını tasarlamak ve koruma stratejileri geliştirmek için hedeflerin belirlenmesinde rehber olarak yararlı olabilir.Atak-S layered hybrid, developed by the "Ankara Poultry Research Institute", is the hybrid with the highest egg productivity among local hybrids. However, egg yield are lower compared to foreign-origin hybrids such as Isa brown. Molecular development studies as to productivity are required for Atak-S hybrid to be able to compete with foreign-origin hybrids. The objective of this study was to detect genetic diversity within the breeds and to compare the Atak-S and Isa Brown breeds. To achieve this goal, we individually genotyped 6 SSR loci in 200 chickens from two populations. 85 polymorphic fragments were found in total for 6 different SSR markers employed in this study. For all loci, high He was observed, and means He was 0.61±0.05 among loci. Among breeds, the mean He was 0.35±0.76 in Atak-S and 0.26±0.68 in Isa Brown. This result indicated that genetic diversity in the Atak-S breed is higher than in the Isa Brown breed. Furthermore, genetic differences and population structure of two hybrids were shown by virtue of dendogram analysis and differences were detected. As a result, we could be suggested that genetic diversity is well preserved within and between Atak-S and Isa Brown hybrids. Based on the Atak-S and Isa Brown breeds estimated by microsatellite analysis may be useful as a guide in setting goals for designing future genetic variation studies and for improving conservation strategies

N-(Diphenyl­carbamothio­yl)-3-methyl­benzamide

The synthesis of the title compound, C21H18N2OS, involves the reaction of 3-methyl­benzoyl chloride with potassium thio­cyanate in dry acetone followed by condensation of the 3-methyl­benzoyl isothio­cyanate with diphenyl­amine. The carbonyl [C—O = 1.215 (2) Å] and thio­carbonyl [C—S = 1.6721 (17) Å] distances indicate that these correspond to double bonds. The short C—N bonds at the center of the mol­ecule reveal the effects of resonance in this part of the mol­ecule. The conformation of the mol­ecule with respect to the thio­carbonyl and carbonyl groups is twisted. The 3-methyl­phenyl and two phenyl rings are also twisted, with dihedral angles of 75.67 (9) and 14.91 (9)°. The phenyl rings are rotated out of the mean plane of the N—C—S—N atoms by 66.87 (8) and 78.40 (9)°. Pairs of mol­ecules are linked into centrosymmetric dimers via inter­molecular N—H⋯S inter­actions and a C—H⋯O link also occurs. The dimers are stacked along the a axis

4-Chloro-N-[N-(6-methyl-2-pyrid­yl)car­bamo­thio­yl]benzamide

In the title compound, C14H12ClN3OS, the short exocyclic N—C bond lengths indicate resonance in the thiourea part of the mol­ecule. The title compound is stabilized by an intra­molecular N—H⋯N hydrogen bond, which results in the formation of a six-membered ring. In addition, it shows a synperiplanar conformation between the thio­carbonyl group and the pyridine group. Inter­molecular N—H⋯S and C—H⋯O inter­actions are also present

Antibacterial Effects of Fluoride-Releasing Orthodontic Composites: A Pilot Study

Aim:The purpose of this study was to evaluate the antibacterial effects of 3 different fluoride-releasing orthodontic composites using a direct contact test (DCT).Materials and Methods:The antibacterial properties of fluoride releasing orthodontic composites were evaluated with the DCT. For the DCT, wells (n=8) of 96-microtitre plates were coated with the tested bonding adhesives [Transbond Plus (3M Unitek, Monrovia, USA) Light Bond (Reliance Ortho Prod. Inc. Itasca, IL, USA) Kurasper F (Kuraray Medical Inc. Okayama, Japan)]. Kalzinol (Zinc-Oxide Eugenol Cement) (Dentsply, Konstanz, Germany was used as a positive control material. A Streptococcus mutans suspension was placed on the surface of each specimen for 1 hour at 37°C. Bacterial growth was monitored for 16 hours with a temperature-controlled microplate spectrophotometer. The kinetics of the outgrowth in each well was recorded continuously at 650 nm every 30 minutes. The data were analyzed by one-way ANOVA, as well as by Tamhane's T2 multiple comparison test. The level of significance was determined as P < 0.05.Results:The evaluation of the results of the DCT revealed that there were statistically significant differences between the four groups (F= 156,951, P= 0.000). The control material (Kalzinol) showed complete inhibition of bacterial growth (mean 0.01 ±0.05). The multiple comparison test indicated that there were no significant difference in bacterial growth between Kalzinol and Transbond Plus (mean 0.12±0.17) (P= 0.509).. Kurasper F (mean 0.73±0.06) and Light Bond (mean 0.85±0.02) showed statistically significant differences (P= 0.000) compared to Kalzinol.Conclusion:Transbond Plus showed marked antibacterial effects

Servikal örneklerde human papillomavirus sıklığı ve genotip dağılımı

Amaç: Servikal kanser kadınlarda ikinci en yaygın kanser tipidir ve kansere bağlı ölümlerin de ikinci en sık nedenidir. Yapılan epidemiyolojik çalışmalar serviks kanseri için majör risk faktörünün human papillomavirus HPV olduğunu göstermiştir. Bu çalışmanın amacı HPV DNA araştırılması için laboratuvarımıza gönderilen servikal örneklerde HPV varlığının ve genotiplerinin belirlenmesidir. Gereç ve Yöntem: İncelenen servikal örneklerde PCR yöntemi ile HPV DNA araştırıldı ve revers hibridizasyon yöntemi ile HPV tiplendirilmesi yapıldı. Bulgular: Çalışmaya alınan ikiyüzelli adet servikal örnekten 29’u %11.6 sadece yüksek riskli, 12’si %4.8 sadece düşük riskli ve 7’si %2.8 yüksek ve düşük riskli birlikte pozitif olmak üzere toplam 48 %19.2 örnekte HPV DNA saptandı. Yüksek riskli HPV genotiplerinden HPV 16 %18.7 ve HPV 30’s+50’s %1 2.5 oranında tespit edildi. Sonuç: Çalışmamızda yüksek riskli tiplerden olan HPV 16 en yüksek oranda saptanırken diğer tipler ise farklı sıklıklarda belirlenmiştir. Ülkemizde HPV DNA ve HPV tip prevalansının saptanması ve HPV aşısının kapsadığı popülasyonun belirlenmesi için benzer demografik özelliklere sahip hasta/kontrol gruplarının katıldığı ve standart bir yöntemin kullanıldığı geniş kapsamlı çalışmalara ihtiyaç vardı

Orbital Complications of Acute Sinusitis: Evaluation, Management, and Results

Objective: Even though acute rhinosinusitis orbital complications are not very common, they can appear as very severe complications with high mortality rates, due to infection spreading to orbital and intracranial tissues. The objective of this study is to assess the treatment and its results for patients treated in our clinic due to rhinosinusitis complications.Methods:Patients who were admitted to our clinic due to acute rhinosinusitis complications between January 2010 and March 2012 were examined. We retrospectively evaluated 11 patients 8 (73%) males and 3 (23%) females with a mean age 12.36 years (range 6-20 years)who were treated for orbital complications of acute rhinosinusitis. Cases were evaluated according to age, sex, etiologic factors, localization, treatment, and outcome.Results: Preseptal cellulitis was observed in 9 patients (82%), orbital abscess was observed in 1 patient (9%), and subperiosteal abscess was observed in 1 patient (9%). Ten of 11 patients achieved full recovery through medical treatment, whereas 1 patient was treated with right subperiosteal abscess drainage and right functional endoscopic sinus surgery due to subperiosteal abscess. The patients’ average admission duration was 7 days.Conclusion: The orbita is the area with the most common sinusitis complications, due to its proximity to the paranasal sinuses and especially to ethmoid cells. Early diagnosis and aggressive treatment are important for the reduction of unwanted manifestations. Computed tomography with contrast remains the optimal imaging study for orbital inflammation. Surgical treatment is indicated when subperiosteal orbital abscess and orbital abscess are scenes