Non-motor symptom burden in patients with Parkinson's disease with impulse control disorders and compulsive behaviours : results from the COPPADIS cohort

The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson's disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose

Eficacia de principios activos de biocidas de la madera para el control del nematodo del pino (Bursaphelenchus xylophilus)

El nematodo de la marchitez del pino (PWN), Bursaphelenchus xylophilus, se considera uno de los organismos más dañinos de las masas forestales de Coníferas, por lo que está declarado como un organismo de cuarentena en Europa. La normativa existente para prevenir su dispersión por la comercialización de la madera de embalajes, es la Norma Internacional para Medidas Fitosanitarias No. 15 (ISPM 15), basada fundamentalmente en un tratamiento térmico. Por otro lado, la madera se trata con productos específicos contra los organismos xilófagos, y el sector industrial está cuestionando si las medidas adoptadas son suficientes y efectivas frente al PWN, por lo que el objetivo de este trabajo ha sido evaluar el efecto biocida de los principios activos más habituales presentes en las formulaciones de los protectores de la madera, frente al nematodo. Los resultados del estudio mostraron que, de los once compuestos activos estudiados, cloruro de didecil dimetilamonio (DDAC), N-butilcarbamato de 3-iodoprop-2-inilo (IPBC), hidroxicarbonato de cobre, diclofluanida, propionato de N, N-didecil-N-metil-poli (oxietil) amonio (Bardap 26) y cloruro de benzalconio (BAC) ofrecían una buena eficacia frente al PWN, ofreciendo un valor añadido a los productos químicos actualmente utilizados en la protección de la madera

Aplicacion del metodo de la figura de merito a la metrologia por centelleo liquido de muestras doblemente marcadas con &quot;3H y &quot;1&quot;4C

Centro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid. SPAIN / CINDOC - Centro de Informaciòn y Documentaciòn CientìficaSIGLEESSpai