Cytotoxic prenylated indole alkaloid produced by the endophytic fungus Aspergillus terreus P63

Prenyl indole alkaloids constitute a diverse class of natural products with complex chemical structures and potent biological activities. Investigation of the growth medium EtOAc extract produced by the endophytic fungus Aspergillus terreus P63 collected from roots of the grass Axonopus leptostachyus, yielded the prenylated indole alkaloid, giluterrin, bearing an unprecedented carbon skeleton. The structure of giluterrin was established by analysis of spectroscopic data and HRMS. The absolute configuration of giluterrin was determined by combination of electronic and vibrational circular dichroism analyses. Giluterrin presented antiproliferative profile for prostate (PC-3) and kidney (786-0) cancer cell lines32162167CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPsem informação2013/50228-8; 2014/25222-9National Council for Scientific and Technological Development (CNPq)National Council for Scientific and Technological Development (CNPq); National Institute of Science and Technology (INCT BioNat), Brazil [465637/2014-0]; National Institute of Science and Technology (INCT Areas Umidas), Brazil [421733/2017-9]; Sao Paulo State Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/50228-8, 2014/25222-9]; Centre for Scientific Computing (NCC/GridUNESP) of Sao Paulo State University (UNESP); FAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP

Estresse pós-traumático da criança sobrevivente de câncer e sua percepção acerca da experiência parental Post-Traumatic stress disorder of the child survivor of cancer and their perception about parental experience

Nas últimas décadas, paralelamente ao aumento progressivo das taxas de cura em Oncologia Pediátrica, evidencia-se um interesse crescente pela sobrevivência ao câncer na infância. Esta investigação teve como objetivo analisar essa experiência de sobrevivência ao câncer na infância, enfatizando a percepção da criança acerca da experiência parental e avaliando o Transtorno de Estresse Pós-traumático infantil nesse contexto. Realizaram-se entrevistas semiestruturadas com a criança, complementadas pela aplicação do UCLA Posttraumatic Stress Disorder Reaction Index for DSM-IV - Child Version. Evidenciaram-se taxas moderadas de diagnóstico total e parcial de Transtorno de Estresse Pós-Traumático. Especificamente no que se refere aos sintomas de estresse pós-traumático, os escores encontrados foram baixos. Os resultados também sugeriram uma relação entre o modo como a experiência parental é percebida pela criança e o escore total de gravidade de Transtorno de Estresse Pós-traumático Infantil. Recomendam-se estudos com amostras mais extensas, visando disponibilizar instrumentos de avaliação para a área da saúde.<br>This investigation aimed to describe, analyze and comprehend the experience of survival after childhood cancer, emphasizing the child's perception of the parent's experience and the evaluation of the child Post-Traumatic Stress Disorder. So, semi-structured interviews were conducted with the participants, who also answered the UCLA Posttraumatic Stress Disorder Reaction Index for DSM-IV - Child Version. The child's perception of the parental experience confirmed evidences pointed out by specialized literature. The total and partial diagnosis rates of Post-Traumatic Stress Disorder were moderate. Finally, it was possible to suggest a likely connection between the way the parental experience is perceived and the total severity score of the Post-Traumatic Stress Disorder in children. Further investigation, with more significant samples, is recommended in order to develop evaluation tools to be applied in other health situations