344 research outputs found
Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
Background: Thyroid receptors, TRα and TRβ, are involved in important physiological functions such as metabolism, cholesterol level and heart activities. Whereas metabolism increase and cholesterol level lowering could be achieved by TRβ isoform activation, TRα activation affects heart rates. Therefore, β-selective thyromimetics have been developed as promising drug-candidates for treatment of obesity and elevated cholesterol level. GC-1 [3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)-phenoxy acetic acid] has ability to lower LDL cholesterol with 600- to 1400-fold more potency and approximately two- to threefold more efficacy than atorvastatin (Lipitor©) in studies in rats, mice and monkeys.
Results: To investigate GC-1 specificity, we solved crystal structures and performed molecular dynamics simulations of both isoforms complexed with GC-1. Crystal structures reveal that, in TRα Arg228 is observed in multiple conformations, an effect triggered by the differences in the interactions between GC-1 and Ser277 or the corresponding asparagine (Asn331) of TRβ. The corresponding Arg282 of TRβ is observed in only one single stable conformation, interacting effectively with the ligand. Molecular dynamics support this model: our simulations show that the multiple conformations can be observed for the Arg228 in TRα, in which the ligand interacts either strongly with the ligand or with the Ser277 residue. In contrast, a single stable Arg282 conformation is observed for TRβ, in which it strongly interacts with both GC-1 and the Asn331.
Conclusion: Our analysis suggests that the key factors for GC-1 selectivity are the presence of an oxyacetic acid ester oxygen and the absence of the amino group relative to T3. These results shed light into the β-selectivity of GC-1 and may assist the development of new compounds with potential as drug candidates to the treatment of hypercholesterolemia and obesity
SARS-CoV-2 uses CD4 to infect T helper lymphocytes
- Author
- Agrela Marcus V
- Amorim Mariene R
- Bernardes Ana F
- Bispos-dos-Santos Karina
- Bloyet Louis-Marie
- Boldrini Vinicius O
- Brunetti Natalia S
- Buscaratti Lucas I
- Carregari Victor C
- Carvalho Murilo
- Carvalho Robson F
- Castelucci Bianca G
- Castro Icaro MS
- Coimbra Laís D
- Crunfli Fernanda
- Cunha Thiago Mattar
- da Silva Luis LP
- Damasio André
- Davanzo Gustavo G
- de Moraes Diogo
- de Oliveira Eduardo B
- Dias Artur HS
- Dias Marieli MG
- Faca Vitor M
- Farias Alessandro S
- Ferrari Allan JR
- Figueira Ana Carolina M
- Forato Julia
- Gerhardt Jaqueline A
- Gomes Arilson Bernardo SP
- Granja Fabiana
- Knittel Thiago L
- Ludwig Raissa G
- Mansour Eli
- Marques Ana Maria
- Marques Rafael E
- Marques-Souza Henrique
- Martini Matheus Cavalheiro
- Martins-de-Souza Daniel
- Monteiro Lauar B
- Moraes-Vieira Pedro MM
- Moretti Maria Luiza
- Mori Marcelo A
- Munhoz-Alves Natália
- Muraro Stéfanie Primon
- Nakaya Helder I
- Nunes Santos Luana
- Nunes Thyago A
- Palma André C
- Parise Pierina Lorencini
- Pereira Alexandre B
- Pereira Fabricio B
- Pontelli Marjorie C
- Proenca-Modena Jose Luiz
- Profeta Gerson S
- Ribeiro Luciana C
- Rodrigues Patricia B
- Santos Leonilda MB
- Sesti-Costa Renata
- Silva-Costa Lícia C
- Silvestrini Virgínia C
- Simeoni Camila L
- Skaf Munir S
- Souza Gabriela F
- Sposito Andrei C
- Stumpf Spencer
- Tavares Lucas A
- Toledo-Teixeira Daniel A
- Ulaf Raisa G
- Velloso Licio
- Veras Flavio P
- Vieira André S
- Vinolo Marco AR
- Virgílio-da-Silva João Victor
- Wassano Natália S
- Whelan Sean
- Publication venue
- Publication date
- 31/07/2023
- Field of study
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such as lymphocytopenia and cytokine storm, which are associated with the severity of the disease and predict mortality. The mechanism by which SARS-CoV-2 infection may result in immune system dysfunction is still not fully understood. Here, we show that SARS-CoV-2 infects human CD4+ T helper cells, but not CD8+ T cells, and is present in blood and bronchoalveolar lavage T helper cells of severe COVID-19 patients. We demonstrated that SARS-CoV-2 spike glycoprotein (S) directly binds to the CD4 molecule, which in turn mediates the entry of SARS-CoV-2 in T helper cells. This leads to impaired CD4 T cell function and may cause cell death. SARS-CoV-2-infected T helper cells express higher levels of IL-10, which is associated with viral persistence and disease severity. Thus, CD4-mediated SARS-CoV-2 infection of T helper cells may contribute to a poor immune response in COVID-19 patients.</p
SARS-CoV-2 uses CD4 to infect T helper lymphocytes
- Author
- Agrela Marcus V
- Amorim Mariene R
- Bernardes Ana F
- Bispos-dos-Santos Karina
- Bloyet Louis-Marie
- Boldrini Vinicius O
- Brunetti Natalia S
- Buscaratti Lucas I
- Carregari Victor C
- Carvalho Murilo
- Carvalho Robson F
- Castelucci Bianca G
- Castro Icaro MS
- Coimbra Laís D
- Crunfli Fernanda
- Cunha Thiago Mattar
- da Silva Luis LP
- Damasio André
- Davanzo Gustavo G
- de Moraes Diogo
- de Oliveira Eduardo B
- Dias Artur HS
- Dias Marieli MG
- Faca Vitor M
- Farias Alessandro S
- Ferrari Allan JR
- Figueira Ana Carolina M
- Forato Julia
- Gerhardt Jaqueline A
- Gomes Arilson Bernardo SP
- Granja Fabiana
- Knittel Thiago L
- Ludwig Raissa G
- Mansour Eli
- Marques Ana Maria
- Marques Rafael E
- Marques-Souza Henrique
- Martini Matheus Cavalheiro
- Martins-de-Souza Daniel
- Monteiro Lauar B
- Moraes-Vieira Pedro MM
- Moretti Maria Luiza
- Mori Marcelo A
- Munhoz-Alves Natália
- Muraro Stéfanie Primon
- Nakaya Helder I
- Nunes Santos Luana
- Nunes Thyago A
- Palma André C
- Parise Pierina Lorencini
- Pereira Alexandre B
- Pereira Fabricio B
- Pontelli Marjorie C
- Proenca-Modena Jose Luiz
- Profeta Gerson S
- Ribeiro Luciana C
- Rodrigues Patricia B
- Santos Leonilda MB
- Sesti-Costa Renata
- Silva-Costa Lícia C
- Silvestrini Virgínia C
- Simeoni Camila L
- Skaf Munir S
- Souza Gabriela F
- Sposito Andrei C
- Stumpf Spencer
- Tavares Lucas A
- Toledo-Teixeira Daniel A
- Ulaf Raisa G
- Velloso Licio
- Veras Flavio P
- Vieira André S
- Vinolo Marco AR
- Virgílio-da-Silva João Victor
- Wassano Natália S
- Whelan Sean
- Publication venue
- Publication date
- 31/07/2023
- Field of study
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such as lymphocytopenia and cytokine storm, which are associated with the severity of the disease and predict mortality. The mechanism by which SARS-CoV-2 infection may result in immune system dysfunction is still not fully understood. Here, we show that SARS-CoV-2 infects human CD4+ T helper cells, but not CD8+ T cells, and is present in blood and bronchoalveolar lavage T helper cells of severe COVID-19 patients. We demonstrated that SARS-CoV-2 spike glycoprotein (S) directly binds to the CD4 molecule, which in turn mediates the entry of SARS-CoV-2 in T helper cells. This leads to impaired CD4 T cell function and may cause cell death. SARS-CoV-2-infected T helper cells express higher levels of IL-10, which is associated with viral persistence and disease severity. Thus, CD4-mediated SARS-CoV-2 infection of T helper cells may contribute to a poor immune response in COVID-19 patients.</p
Muon reconstruction and identification efficiency in ATLAS using the full Run 2 pp collision data set at \sqrt{s}=13 TeV
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Agullo PM
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahnen JV
- Ai X
- Aielli G
- Akatsuka S
- Akbiyik M
- Akesson TPA
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alves FLL
- Alviggi MG
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
- Andari N
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparo MA
- Aranda CP
- Aranzabal N
- Araya ST
- Arcangeletti C
- Arce ATH
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Artoni G
- Asada H
- Asai K
- Asai S
- Asawatavonvanich T
- Asbah NA
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Atmasiddha PA
- Augsten K
- Austrup VA
- Avolio G
- Ayoub MK
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Backman F
- Bagnaia P
- Bahilo JJL
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
- Baker OK
- Bakker PJ
- Bakos E
- Balaji S
- Balasubramanian R
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Banerjee S
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
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- Barisits M-S
- Barkeloo J
- Barklow T
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zieminska D
- Zimine NI
- Zimmermann S
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- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zwalinski L
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/01/2021
- Field of study
This article documents the muon reconstruction and identification efficiency obtained by the ATLAS experiment for 139 \hbox {fb}^{-1} of pp collision data at \sqrt{s}=13 TeV collected between 2015 and 2018 during Run 2 of the LHC. The increased instantaneous luminosity delivered by the LHC over this period required a reoptimisation of the criteria for the identification of prompt muons. Improved and newly developed algorithms were deployed to preserve high muon identification efficiency with a low misidentification rate and good momentum resolution. The availability of large samples of Z\rightarrow \mu \mu and J/\psi \rightarrow \mu \mu decays, and the minimisation of systematic uncertainties, allows the efficiencies of criteria for muon identification, primary vertex association, and isolation to be measured with an accuracy at the per-mille level in the bulk of the phase space, and up to the percent level in complex kinematic configurations. Excellent performance is achieved over a range of transverse momenta from 3 GeV to several hundred GeV, and across the full muon detector acceptance of |\eta |<2.7
Measurements of differential cross-sections in top-quark pair events with a high transverse momentum top quark and limits on beyond the Standard Model contributions to top-quark pair production with the ATLAS detector at √s = 13 TeV
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- Burgard CD
- Burger AM
- Burghgrave B
- Burr JTP
- Burton CD
- Burzynski JC
- Busch EL
- Buscher V
- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Buzykaev AR
- Bylund OB
- Cabras G
- Caforio D
- Cai H
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- Cairo VMM
- Cakir IT
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- Calace N
- Calafiura P
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Calvet D
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- Camarda S
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- Camerlingo MT
- Cameron D
- Camincher C
- Campanelli M
- Camplani A
- Canale V
- Canesse A
- Cantero J
- Cao Y
- Capocasa F
- Capriles FGD
- Capua M
- Carbone A
- Cardarelli R
- Cardenas JCJ
- Cardillo F
- Carducci G
- Carli T
- Carlino G
- Carlson BT
- Carlson EM
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- Carter JWS
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- Casadei D
- Casado MP
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- Castillo FL
- Castillo LRF
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- Catmore JR
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- Chen A
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- Chen X
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- Cheremushkina E
- Cherepanova E
- Cheu E
- Cheung K
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu YH
- Chizhov MV
- Choi K
- Chomont AR
- Chou Y
- Chow YS
- Chowdhury T
- Christopher LD
- Chu MC
- Chu X
- Chudoba J
- Chwastowski JJ
- Cieri D
- Ciesla KM
- Cindro V
- Ciocio A
- Cirotto F
- Citron ZH
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- Ciubotaru DA
- Ciungu BM
- Clark A
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- Clawson SE
- Clement C
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- Corpe LD
- Corradi M
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- Corrigan EE
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- Dam M
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- de Renstrom PAB
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- Dedovich DV
- Degens J
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- Zambito S
- Zanzi D
- Zaplatilek O
- Zeissner SV
- Zeitnitz C
- Zeng JC
- Zenger DT
- Zenin O
- Zenis T
- Zenz S
- Zerradi S
- Zerwas D
- Zhang B
- Zhang DF
- Zhang G
- Zhang J
- Zhang K
- Zhang L
- Zhang M
- Zhang R
- Zhang S
- Zhang X
- Zhang X
- Zhang Z
- Zhao H
- Zhao P
- Zhao T
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou H
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Cross-section measurements of top-quark pair production where the hadronically decaying top quark has transverse momentum greater than 355 GeV and the other top quark decays into ℓνb are presented using 139 fb−1 of data collected by the ATLAS experiment during proton-proton collisions at the LHC. The fiducial cross-section at s = 13 TeV is measured to be σ = 1.267 ± 0.005 ± 0.053 pb, where the uncertainties reflect the limited number of data events and the systematic uncertainties, giving a total uncertainty of 4.2%. The cross-section is measured differentially as a function of variables characterising the tt¯ system and additional radiation in the events. The results are compared with various Monte Carlo generators, including comparisons where the generators are reweighted to match a parton-level calculation at next-to-next-to-leading order. The reweighting improves the agreement between data and theory. The measured distribution of the top-quark transverse momentum is used to search for new physics in the context of the effective field theory framework. No significant deviation from the Standard Model is observed and limits are set on the Wilson coefficients of the dimension-six operators OtG and Otq(8), where the limits on the latter are the most stringent to date. [Figure not available: see fulltext.]
Measurements of Higgs bosons decaying to bottom quarks from vector boson fusion production with the ATLAS experiment at √=13TeV
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/06/2021
- Field of study
The paper presents a measurement of the Standard Model Higgs Boson decaying to b-quark pairs in the vector boson fusion (VBF) production mode. A sample corresponding to 126 fb−1 of s√=13TeV proton–proton collision data, collected with the ATLAS experiment at the Large Hadron Collider, is analyzed utilizing an adversarial neural network for event classification. The signal strength, defined as the ratio of the measured signal yield to that predicted by the Standard Model for VBF Higgs production, is measured to be 0.95+0.38−0.36 , corresponding to an observed (expected) significance of 2.6 (2.8) standard deviations from the background only hypothesis. The results are additionally combined with an analysis of Higgs bosons decaying to b-quarks, produced via VBF in association with a photon
Search for bottom-squark pair production in pp collision events at √s=13 TeV with hadronically decaying τ-leptons, b-jets, and missing transverse momentum using the ATLAS detector
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- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
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- Acharya BS
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- Yexley MR
- Yigitbasi E
- Yildiz HD
- Yin P
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- Yoshihara K
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine N
- Zimmermann S
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- Ziolkowski M
- Zivkovic L
- Zobernig G
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- Zoch K
- Zorbas TG
- Zou R
- Zwalinski L
- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 01/08/2021
- Field of study
A search for pair production of bottom squarks in events with hadronically decaying
τ
-leptons,
b
-tagged jets, and large missing transverse momentum is presented. The analyzed dataset is based on proton-proton collisions at
√
s
=
13
TeV
delivered by the Large Hadron Collider and recorded by the ATLAS detector from 2015 to 2018, and corresponds to an integrated luminosity of
139
fb
−
1
. The observed data are compatible with the expected Standard Model background. Results are interpreted in a simplified model where each bottom squark is assumed to decay into the second-lightest neutralino
˜
χ
0
2
and a bottom quark, with
˜
χ
0
2
decaying into a Higgs boson and the lightest neutralino
˜
χ
0
1
. The search focuses on final states where at least one Higgs boson decays into a pair of hadronically decaying
τ
-leptons. This allows the acceptance and thus the sensitivity to be significantly improved relative to the previous results at low masses of the
˜
χ
0
2
, where bottom-squark masses up to 850 GeV are excluded at the 95% confidence level, assuming a mass difference of 130 GeV between
˜
χ
0
2
and
˜
χ
0
1
. Model-independent upper limits are also set on the cross section of processes beyond the Standard Model
Measurements of differential cross-sections in four-lepton events in 13 TeV proton-proton collisions with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Agullo PM
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akbiyik M
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso F
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- Alvarez Estevez M
- Alves FLL
- Alviggi MG
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
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- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov A
- Annovi A
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- Anthony MT
- Antipov E
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- Atmani H
- Atmasiddha PA
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zwalinski L
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 02/07/2021
- Field of study
Measurements of four-lepton differential and integrated fiducial cross-sections in events with two same-flavour, opposite-charge electron or muon pairs are presented. The data correspond to 139 fb−1 of s√ = 13 TeV proton-proton collisions, collected by the ATLAS detector during Run 2 of the Large Hadron Collider (2015–2018). The final state has contributions from a number of interesting Standard Model processes that dominate in different four-lepton invariant mass regions, including single Z boson production, Higgs boson production and on-shell ZZ production, with a complex mix of interference terms, and possible contributions from physics beyond the Standard Model. The differential cross-sections include the four-lepton invariant mass inclusively, in slices of other kinematic variables, and in different lepton flavour categories. Also measured are dilepton invariant masses, transverse momenta, and angular correlation variables, in four regions of four-lepton invariant mass, each dominated by different processes. The measurements are corrected for detector effects and are compared with state-of-the-art Standard Model calculations, which are found to be consistent with the data. The Z → 4ℓ branching fraction is extracted, giving a value of (4.41 ± 0.30) × 10−6. Constraints on effective field theory parameters and a model based on a spontaneously broken B − L gauge symmetry are also evaluated. Further reinterpretations can be performed with the provided information
Medium-Induced Modification of Z-Tagged Charged Particle Yields in Pb+Pb Collisions at 5.02 TeV with the ATLAS Detector
- Author
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- Abbott B
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- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
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- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 19/02/2021
- Field of study
The yield of charged particles opposite to a
Z
boson with large transverse momentum (
p
T
) is measured in
260
pb
−
1
of
p
p
and
1.7
nb
−
1
of
Pb
+
Pb
collision data at 5.02 TeV per nucleon pair recorded with the ATLAS detector at the Large Hadron Collider. The
Z
boson tag is used to select hard-scattered partons with specific kinematics, and to observe how their showers are modified as they propagate through the quark-gluon plasma created in
Pb
+
Pb
collisions. Compared with
p
p
collisions, charged-particle yields in
Pb
+
Pb
collisions show significant modifications as a function of charged-particle
p
T
in a way that depends on event centrality and
Z
boson
p
T
. The data are compared with a variety of theoretical calculations and provide new information about the medium-induced energy loss of partons in a
p
T
regime difficult to measure through other channels
Search for pair production of third-generation scalar leptoquarks decaying into a top quark and a τ-lepton in pp collisions at s√ = 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
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- Wiedenmann W
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- Wielers M
- Wieseotte N
- Wiglesworth C
- Wiik-Fuchs LAM
- Wilkens HG
- Wilkins LJ
- Williams DM
- Williams HH
- Williams S
- Willocq S
- Windischhofer PJ
- Wingerter-Seez I
- Winkels E
- Winklmeier F
- Winter BT
- Wittgen M
- Wobisch M
- Wolf A
- Wolker R
- Wollrath J
- Wolter MW
- Wolters H
- Wong VWS
- Wongel AF
- Woods NL
- Worm SD
- Wosiek BK
- Wraight K
- Wu SL
- Wu X
- Wu Y
- Wuerzinger J
- Wyatt TR
- Wynne BM
- Xella S
- Xiang J
- Xiao X
- Xie X
- Xiotidis I
- Xu D
- Xu H
- Xu H
- Xu L
- Xu R
- Xu T
- Xu W
- Xu Y
- Xu Z
- Xu Z
- Yabsley B
- Yacoob S
- Yallup DP
- Yamaguchi N
- Yamaguchi Y
- Yamamoto A
- Yamatani M
- Yamazaki T
- Yamazaki Y
- Yan J
- Yan Z
- Yang HJ
- Yang HT
- Yang S
- Yang T
- Yang X
- Yang X
- Yang Y
- Yang Z
- Yao W-M
- Yap YC
- Ye H
- Ye J
- Ye S
- Yeletskikh I
- Yexley MR
- Yigitbasi E
- Yildiz HD
- Yin P
- Yorita K
- Yoshihara K
- Young C
- Young CJS
- Yu J
- Yuan R
- Yue X
- Zaazoua M
- Zabinski B
- Zacharis G
- Zaffaroni E
- Zahreddine J
- Zaitsev AM
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zeissner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
- Zenis T
- Zerwas D
- Zhang B
- Zhang DF
- Zhang G
- Zhang J
- Zhang K
- Zhang L
- Zhang L
- Zhang M
- Zhang R
- Zhang S
- Zhang X
- Zhang X
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao P
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou H
- Zhou M
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine N
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zwalinski L
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 30/06/2021
- Field of study
A search for pair production of third-generation scalar leptoquarks decaying into a top quark and a τ-lepton is presented. The search is based on a dataset of pp collisions at s√ = 13 TeV recorded with the ATLAS detector during Run 2 of the Large Hadron Collider, corresponding to an integrated luminosity of 139 fb−1. Events are selected if they have one light lepton (electron or muon) and at least one hadronically decaying τ -lepton, or at least two light leptons. In addition, two or more jets, at least one of which must be identified as containing b-hadrons, are required. Six final states, defined by the multiplicity and flavour of lepton candidates, are considered in the analysis. Each of them is split into multiple event categories to simultaneously search for the signal and constrain several leading backgrounds. The signal-rich event categories require at least one hadronically decaying τ-lepton candidate and exploit the presence of energetic final-state objects, which is characteristic of signal events. No significant excess above the Standard Model expectation is observed in any of the considered event categories, and 95% CL upper limits are set on the production cross section as a function of the leptoquark mass, for different assumptions about the branching fractions into tτ and bν. Scalar leptoquarks decaying exclusively into tτ are excluded up to masses of 1.43 TeV while, for a branching fraction of 50% into tτ, the lower mass limit is 1.22 TeV
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