The day the river ran away: The impact of a children\u27s literature book and accompanying curriculum upon student perceptions of the Salton Sea

This project is focused on an author-created children\u27s literature book about the Salton Sea called The Day the River Ran Away . An accompanying curriculum has been developed for third grade students to increase knowledge of ecological foundations and conceptual awarenes

Whither History of Women in the Americas?

This is the publisher's version, also available electronically from http://journals.sas.ac.uk/hwa/article/view/1690This article charts conceptual developments in the field of history of women in the Americas over the past forty years since the author began her career. It compares women’s and gender history and the contributions of key figures such as Joan Scott, Alice Kessler-Harris, and Barbara Welter along with recent developments in the field such as the history of women in the Atlantic world. The article also proposes reasons for the separation of American women’s history into North American, Latin American, and Caribbean fields

Women's Labor History

This is the publisher's version, also available electronically from http://www.jstor.org/stable/2703424?seq=1#page_scan_tab_contents.No abstract is available for this item

Associations between student levels of achievement and perceptions of teacher-student interactions

This thesis reports on a research study of the associations between the interpersonal interactions students have with their teachers and shifts in cognitive achievement. Effect sizes were calculated to determine the shifts students had in cognitive achievement and these were compared to the perceptions of the teacher student interactions that were gathered using the Questionnaire on Teacher Interaction (QTI). This was one of the first times that the QTI was used in a New Zealand Primary School. The 48-item QTI was used and shown to be both valid and reliable within the New Zealand Primary School context.The study found that there was a correlation between the interpersonal interactions and cognitive achievement of students. Students generally had better achievement shifts with teachers that matched the Tolerant/Authoritative typology and lower shifts with teachers who matched the Directive typology. The study also confirmed that there is variance of teachers within schools. It is this variance that needs addressing and the tools used in this research enable teachers and educators to make decisions about what is working within a classroom and what is not. This leads to opportunities for the professional development of teachers, which will in turn improve both the learning environment and cognitive achievement of the students. Teaching and learning are complex and determining what and where to improve can only happen effectively when you have evidence of what is occurring. The tools used in this study provide that evidence, and when you have the evidence, you have the ability to make powerful changes in the lives of students

Unusual catalytic strategy by non-heme Fe(ii)/2-oxoglutarate-dependent aspartyl hydroxylase AspH

Biocatalytic C-H oxidation reactions are of important synthetic utility, provide a sustainable route for selective synthesis of important organic molecules, and are an integral part of fundamental cell processes. The multidomain non-heme Fe(ii)/2-oxoglutarate (2OG) dependent oxygenase AspH catalyzes stereoselective (3R)-hydroxylation of aspartyl- and asparaginyl-residues. Unusually, compared to other 2OG hydroxylases, crystallography has shown that AspH lacks the carboxylate residue of the characteristic two-His-one-Asp/Glu Fe-binding triad. Instead, AspH has a water molecule that coordinates Fe(ii) in the coordination position usually occupied by the Asp/Glu carboxylate. Molecular dynamics (MD) and quantum mechanics/molecular mechanics (QM/MM) studies reveal that the iron coordinating water is stabilized by hydrogen bonding with a second coordination sphere (SCS) carboxylate residue Asp721, an arrangement that helps maintain the six coordinated Fe(ii) distorted octahedral coordination geometry and enable catalysis. AspH catalysis follows a dioxygen activation-hydrogen atom transfer (HAT)-rebound hydroxylation mechanism, unusually exhibiting higher activation energy for rebound hydroxylation than for HAT, indicating that the rebound step may be rate-limiting. The HAT step, along with substrate positioning modulated by the non-covalent interactions with SCS residues (Arg688, Arg686, Lys666, Asp721, and Gln664), are essential in determining stereoselectivity, which likely proceeds with retention of configuration. The tetratricopeptide repeat (TPR) domain of AspH influences substrate binding and manifests dynamic motions during catalysis, an observation of interest with respect to other 2OG oxygenases with TPR domains. The results provide unique insights into how non-heme Fe(ii) oxygenases can effectively catalyze stereoselective hydroxylation using only two enzyme-derived Fe-ligating residues, potentially guiding enzyme engineering for stereoselective biocatalysis, thus advancing the development of non-heme Fe(ii) based biomimetic C-H oxidation catalysts, and supporting the proposal that the 2OG oxygenase superfamily may be larger than once perceived

Unusual catalytic strategy by non-heme Fe(ii)/2-oxoglutarate-dependent aspartyl hydroxylase AspH

Biocatalytic C-H oxidation reactions are of important synthetic utility, provide a sustainable route for selective synthesis of important organic molecules, and are an integral part of fundamental cell processes. The multidomain non-heme Fe(ii)/2-oxoglutarate (2OG) dependent oxygenase AspH catalyzes stereoselective (3R)-hydroxylation of aspartyl- and asparaginyl-residues. Unusually, compared to other 2OG hydroxylases, crystallography has shown that AspH lacks the carboxylate residue of the characteristic two-His-one-Asp/Glu Fe-binding triad. Instead, AspH has a water molecule that coordinates Fe(ii) in the coordination position usually occupied by the Asp/Glu carboxylate. Molecular dynamics (MD) and quantum mechanics/molecular mechanics (QM/MM) studies reveal that the iron coordinating water is stabilized by hydrogen bonding with a second coordination sphere (SCS) carboxylate residue Asp721, an arrangement that helps maintain the six coordinated Fe(ii) distorted octahedral coordination geometry and enable catalysis. AspH catalysis follows a dioxygen activation-hydrogen atom transfer (HAT)-rebound hydroxylation mechanism, unusually exhibiting higher activation energy for rebound hydroxylation than for HAT, indicating that the rebound step may be rate-limiting. The HAT step, along with substrate positioning modulated by the non-covalent interactions with SCS residues (Arg688, Arg686, Lys666, Asp721, and Gln664), are essential in determining stereoselectivity, which likely proceeds with retention of configuration. The tetratricopeptide repeat (TPR) domain of AspH influences substrate binding and manifests dynamic motions during catalysis, an observation of interest with respect to other 2OG oxygenases with TPR domains. The results provide unique insights into how non-heme Fe(ii) oxygenases can effectively catalyze stereoselective hydroxylation using only two enzyme-derived Fe-ligating residues, potentially guiding enzyme engineering for stereoselective biocatalysis, thus advancing the development of non-heme Fe(ii) based biomimetic C-H oxidation catalysts, and supporting the proposal that the 2OG oxygenase superfamily may be larger than once perceived