9,810 research outputs found
Stretched exponentials and power laws in granular avalanching
We introduce a model for granular avalanching which exhibits both stretched exponential and power law avalanching over its parameter range. Two modes of transport are incorporated, a rolling layer consisting of individual particles and the overdamped, sliding motion of particle clusters. The crossover in behaviour observed in experiments on piles of rice is attributed to a change in the dominant mode of transport. We predict that power law avalanching will be observed whenever surface flow is dominated by clustered motion.
Comment: 8 pages, more concise and some points clarified
Extended-release niacin increases anti-apolipoprotein A-I antibodies that block the antioxidant effect of high-density lipoprotein-cholesterol: the EXPLORE clinical trial.
Extended-release niacin (ERN) is the most effective agent for increasing high-density lipoprotein-cholesterol (HDL-C). Having previously identified anti-HDL antibodies, we investigated whether ERN affected the antioxidant capacity of HDL and whether ERN was associated with the production of antibodies against HDL (aHDL) and apolipoprotein A-I (aApoA-I).
METHODS:
Twenty-one patients older than 18 years, with HDL-C ≤40 mg dl-1 (men) or ≤50 mg dl-1 (women) were randomly assigned to receive daily ERN (n = 10) or placebo (n = 11) for two sequential 12-week periods, with 4 weeks of wash-out before cross-over. Primary outcome was change of paraoxonase-1 (PON1) activity and secondary outcomes were changes in aHDL and aApoA-I antibodies. Clinical Trial Unique Identifier: EudraCT 2006-006889-42.
RESULTS:
The effect of ERN on PON1 activity was nonsignificant (coefficient estimate 20.83 U l-1 , 95% confidence interval [CI] -9.88 to 51.53; P = 0.184). ERN was associated with an increase in HDL-C levels (coefficient estimate 5.21 mg dl-1 , 95% CI 1.16 to 9.25; P = 0.012) and its subclasses HDL2 (coefficient estimate 2.46 mg dl-1 , 95% CI 0.57 to 4.34; P = 0.011) and HDL3 (coefficient estimate 2.73 mg dl-1 , 95% CI 0.47 to 4.98; P = 0.018). ERN was significantly associated with the production of aApoA-I antibodies (coefficient estimate 0.25 ÎĽg ml-1 , 95% CI 0.09-0.40; P = 0.001). aApoA-I titres at baseline were correlated with decreased PON activity.
CONCLUSIONS:
The rise in HDL-C achieved with ERN was not matched by improved antioxidant capacity, eventually hampered by the emergence of aApoA-I antibodies. These results may explain why Niacin and other lipid lowering agents fail to reduce cardiovascular risk.info:eu-repo/semantics/publishedVersio
Ice Age Epochs and the Sun's Path Through the Galaxy
We present a calculation of the Sun's motion through the Milky Way Galaxy
over the last 500 million years. The integration is based upon estimates of the
Sun's current position and speed from measurements with Hipparcos and upon a
realistic model for the Galactic gravitational potential. We estimate the times
of the Sun's past spiral arm crossings for a range in assumed values of the
spiral pattern angular speed. We find that for a difference between the mean
solar and pattern speed of Omega_Sun - Omega_p = 11.9 +/- 0.7 km/s/kpc the Sun
has traversed four spiral arms at times that appear to correspond well with
long duration cold periods on Earth. This supports the idea that extended
exposure to the higher cosmic ray flux associated with spiral arms can lead to
increased cloud cover and long ice age epochs on Earth.Comment: 14 pages, 3 figures, accepted for publication in Ap
Zoneamento de riscos climáticos da cultura da mamoneira no Estado de Sergipe, referente ao ano safra de 2006/2007.
bitstream/CNPA/18400/1/COMTEC294.pd
Zoneamento de riscos climáticos da cultura da mamoneira no Estado do Rio Grande do Norte, referente ao ano safra de 2006/2007.
bitstream/CNPA/18397/1/COMTEC293.pd
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