Use of biological based therapy in patients with cardiovascular diseases in a university-hospital in New York City

BACKGROUND: The use of complementary and alternative products including Biological Based Therapy (BBT) has increased among patients with various medical illnesses and conditions. The studies assessing the prevalence of BBT use among patients with cardiovascular diseases are limited. Therefore, an evaluation of BBT in this patient population would be beneficial. This was a survey designed to determine the effects of demographics on the use of Biological Based Therapy (BBT) in patients with cardiovascular diseases. The objective of this study was to determine the effect of the education level on the use of BBT in cardiovascular patients. This survey also assessed the perceptions of users regarding the safety/efficacy of BBT, types of BBT used and potential BBT-drug interactions. METHOD: The survey instrument was designed to assess the findings. Patients were interviewed from February 2001 to December 2002. 198 inpatients with cardiovascular diseases (94 BBT users and 104 non-users) in a university hospital were included in the study. RESULTS: Users had a significantly higher level of education than non-users (college graduate: 28 [30%] versus 12 [12%], p = 0.003). Top 10 BBT products used were vitamin E [41(43.6%)], vitamin C [30(31.9%)], multivitamins [24(25.5%)], calcium [19(20.2%)], vitamin B complex [17(18.1%)], fish oil [12(12.8%)], coenzyme Q10 [11(11.7%)], glucosamine [10(10.6%)], magnesium [8(8.5%)] and vitamin D [6(6.4%)]. Sixty percent of users' physicians knew of the BBT use. Compared to non-users, users believed BBT to be safer (p < 0.001) and more effective (p < 0.001) than prescription drugs. Forty-two potential drug-BBT interactions were identified. CONCLUSION: Incidence of use of BBT in cardiovascular patients is high (47.5%), as is the risk of potential drug interaction. Health care providers need to monitor BBT use in patients with cardiovascular diseases

Salt stress and senescence: identification of cross-talk regulatory components

Leaf senescence is an active process with a pivotal impact on plant productivity. It results from extensive signalling cross-talk coordinating environmental factors with intrinsic age-related mechanisms. Although many studies have shown that leaf senescence is affected by a range of external parameters, knowledge about the regulatory systems that govern the interplay between developmental programmes and environmental stress is still vague. Salinity is one of the most important environmental stresses that promote leaf senescence and thus affect crop yield. Improving salt tolerance by avoiding or delaying senescence under stress will therefore play an important role in maintaining high agricultural productivity. Experimental evidence suggests that hydrogen peroxide (H2O2) functions as a common signalling molecule in both developmental and salt-induced leaf senescence. In this study, microarray-based gene expression profiling on Arabidopsis thaliana plants subjected to long-term salinity stress to induce leaf senescence was performed, together with co-expression network analysis for H2O2-responsive genes that are mutually up-regulated by salt induced- and developmental leaf senescence. Promoter analysis of tightly co-expressed genes led to the identification of seven cis-regulatory motifs, three of which were known previously, namely CACGTGT and AAGTCAA, which are associated with reactive oxygen species (ROS)-responsive genes, and CCGCGT, described as a stress-responsive regulatory motif, while the others, namely ACGCGGT, AGCMGNC, GMCACGT, and TCSTYGACG were not characterized previously. These motifs are proposed to be novel elements involved in the H2O2-mediated control of gene expression during salinity stress-triggered and developmental senescence, acting through upstream transcription factors that bind to these sites

Towards (re)constructing narratives from georeferenced photographs through visual analytics

We present a study that explores methodological steps towards (re)constructing collective narratives from the photo-taking behaviour of two groups (foreign tourists and inhabitants of Switzerland) by analysing spatial and temporal patterns in user-contributed, georeferenced photographs of Zurich, Switzerland. We reason that the photographers typically capture a scene or a moment because they want to remember or share it, thus these scenes or moments are meaningful to them. Various scholars suggest that the human experience (i.e. this meaningfulness) is what separates a place from the mathematical descriptions of space. While this notion is well known in larger geographic literature, it is under-explored in cartographic research. We respond to this research gap and reconstruct static and dynamic patterns of photo-taking and -sharing behaviour to assist in capturing the implicit meaning in the studied locations. These locations may be meaningful to only a certain group of people in certain moments; therefore, studying group differences in spatial and temporal photo-taking patterns will help building a collective and comparative story about the studied place. In our study, we focus on experiences of foreign versus domestic visitors, and in the process, we examine the potential (and feasibility) of georeferenced photographs for extracting such collective narratives using qualitative and quantitative visual analytical methods

Illiberal Peace? Authoritarian modes of conflict management

This is the author accepted manuscript. The final version is available from SAGE Publications via the DOI in this recordIn a contested international order, ideas of liberal peacebuilding are being supplanted by state-centric, authoritarian responses to internal armed conflicts. In this article we suggest that existing research has not yet sufficiently recognised this important shift in conflict management practice. Scholarship in peace and conflict studies has avoided hard cases of ‘illiberal peace’, or categorises them simply as military victories. Drawing on accounts of state responses to conflicts in Russia, Sri Lanka, China, Ethiopia, Rwanda and Turkey, we develop an alternative conceptual framework to understand authoritarian conflict management as a form of wartime and post-conflict order in its own right. Although violence is central to these orders, we argue that they are also dependent on a much wider range of authoritarian policy responses, which we categorise in three major domains: firstly, discourse (state propaganda, information control and knowledge production); secondly, spatial politics (both military and civilian modes of controlling and shaping spaces); and thirdly, political economy (the hierarchical distribution of resources to produce particular political outcomes). In conclusion, we propose a research agenda that moves on from discussions of liberal peace to examine hard cases of contemporary conflict and conflict management