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MC2: Subaru and Hubble Space Telescope Weak-lensing Analysis of the Double Radio Relic Galaxy Cluster PLCK G287.0+32.9
The second most significant detection of the Planck Sunyaev-Zel'dovich survey, PLCK G287.0+32.9 (z = 0.385), boasts two similarly bright radio relics and a radio halo. One radio relic is located NW of the X-ray peak and the other Mpc to the SE. This large difference suggests that a complex merging scenario is required. A key missing puzzle for the merging scenario reconstruction is the underlying dark matter distribution in high resolution. We present a joint Subaru Telescope and Hubble Space Telescope weak-lensing analysis of the cluster. Our analysis shows that the mass distribution features four significant substructures. Of the substructures, a primary cluster of mass M200c = 1.59+0.25-0.22 ×1015 h-170 Mo dominates the weak-lensing signal. This cluster is likely to be undergoing a merger with one (or more) subcluster whose mass is approximately a factor of 10 lower. One candidate is the subcluster of mass M200c =1.16 0.15-0.13 ×1014h-170 Molocated ∼ 400 kpc to the SE. The location of this subcluster suggests that its interaction with the primary cluster could be the source of the NW radio relic. Another subcluster is detected ∼2 Mpc to the SE of the X-ray peak with mass M200c = 1.68 +0.22-0.20 ×1014h-170 Mo. This SE subcluster is in the vicinity of the SE radio relic and may have created the SE radio relic during a past merger with the primary cluster. The fourth subcluster, M200c = 1.87 +0.24-0.22×1014h-170 Mo, is NW of the X-ray peak and beyond the NW radio relic
Management of Hair Loss Associated with Endocrine Therapy in Patients with Breast Cancer: An Overview
Endocrine therapy-induced hair loss (ETIHL) associated with aromatase inhibitors and tamoxifen treatment is currently mostly reported but remained an unresolved therapeutic issue in patients with breast cancer (BC) since the number of studies regarding the management is limited in literature. Herein we investigated the possible causes of this clinical problem and its relation with endocrine therapies widely used for BC survivors and made some modest practical recommendations in light of the literature review in order to provide an optimal management. On the basis of literature findings, common causes of hair loss apart from endocrine therapies should be investigated with an initial evaluation workup and then should be corrected, if observed. Treatment with topical 5-alpha reductase inhibitors and supplementation of Vitamin C and omega-3 fatty acids are likely appeared to be the most appropriate treatment agents for ETIHL without causing an adverse effect on BC prognosis. However, more prospective, randomised, placebo-controlled studied are required in order to confirm our results and also identify the clinical effects of this problem on patients with BC.WoSScopusPubMe