Abnormal Downward Gaze and Cold Caloric Examination Due to Propofol: A Case Study

Background: Adolescent patient with isolated abnormal downward gaze and oculovestibular (cold caloric) testing during propofol administration prompting concern of brainstem injury. PATIENT: An otherwise healthy 16 year old female presented after an intentional hanging. Brainstem reflexes were normal except that both eyes were in tonic downgaze on initial examination. Propofol was suspended for 30 minutes to evaluate level of responsiveness with eyes normalizing to midposition from tonic downgaze. With reinitiation of propofol, the eyes returned to the former position. C-collar stabilization prohibited oculocephalic (doll’s eyes) evaluation, and with cold caloric testing, eye movements were as follows: right sided cold water instillation resulted in right eye exodeviation to the right with minimal medial movement of the left eye to the right. Upon left sided instillation, the left eye deviated downward with minimal medial deviation of the right eye. Patient was weaned to extubation within 48 hours of admission, and off sedatives normal ocular motility returned. CONCLUSION: This patient manifested abnormal ocular motility and cold caloric exam with single-agent propofol exposure. The remainder of the cranial nerve exam was normal, and in the context of a normal brain and cervical spine MRI, the clinical picture was inconsistent with brainstem injury leading us to suspect propofol effect. This was supported by the return of normal ocular motility once propofol was discontinued. Consider pharmacologic disturbance of ocular motility and cold caloric testing in the absence of other brainstem dysfunction when concomitant propofol is administered

Budaya Lembaga Pendidikan sebagai Pilar Utama Melawan Degradasi Moral

Moral merupakan bekal dalam mengembangkan diri. Masalah yang Sering terjadi pada moral  adalah masalah yang menjadi perhatian manusia di mana saja, baik dalam masyarakat yang telah maju, maupun dalam masyarakat yang masih tertinggal. Hal itu disebabkan karena kerusakan moral seseorang mengganggu ketenangan  yang lain. Jika dalam masyarakat banyak orang yang rusak moralnya, maka akan terjadinya kerusakan yang terjadi pada masyarakat itu sendiri. Pendidikan moral bagi anak dapat mengubah perilaku anak, sehingga jika sudah dewasa lebih bertanggung jawab dan menghargai sesamanya hingga mampu menghadapi tantangan jaman.. Peningkatan pertimbangan moral pada diri anak yang dirancang melalui pendidikan di sekolah, dapat membantu pembentukan kepribadian anak, karena dengan terbentuknya pertimbangan moral. Menggunakan metode kualitatif serta teori dari Durkheim ada tiga unsur untuk bisa menjadi pribadi yang bermoral yang pertama adalah disiplin; kedua adalah keterikatan pada kelompok; ketiga adalah otonomi. Ketiga unsur ini dibutuhkan setiap individu untuk bisa menjadi pribadi yang bermoral. Penelian ini menghasilkan bahwa ketiga unsur tersebut memberikan peran besar bagi perkembangan moral terutama apabila diterapkan pada suatu jenjang Pendidikan seperti di Lembaga pendidikan

The impact of spectroscopic incompleteness in direct calibration of redshift distributions for weak lensing surveys

Obtaining accurate distributions of galaxy redshifts is a critical aspect of weak lensing cosmology experiments. One of the methods used to estimate and validate redshift distributions is to apply weights to a spectroscopic sample, so that their weighted photometry distribution matches the target sample. In this work, we estimate the selection bias in redshift that is introduced in this procedure. We do so by simulating the process of assembling a spectroscopic sample (including observer-assigned confidence flags) and highlight the impacts of spectroscopic target selection and redshift failures. We use the first year (Y1) weak lensing analysis in Dark Energy Survey (DES) as an example data set but the implications generalize to all similar weak lensing surveys. We find that using colour cuts that are not available to the weak lensing galaxies can introduce biases of up to Δz ∼ 0.04 in the weighted mean redshift of different redshift intervals (Δz ∼ 0.015 in the case most relevant to DES). To assess the impact of incompleteness in spectroscopic samples, we select only objects with high observer-defined confidence flags and compare the weighted mean redshift with the true mean. We find that the mean redshift of the DES Y1 weak lensing sample is typically biased at the Δz = 0.005−0.05 level after the weighting is applied. The bias we uncover can have either sign, depending on the samples and redshift interval considered. For the highest redshift bin, the bias is larger than the uncertainties in the other DES Y1 redshift calibration methods, justifying the decision of not using this method for the redshift estimations. We discuss several methods to mitigate this bias

Phase noise characterisation of a 2-km hollow-core nested antiresonant nodeless fibre for twin-field quantum key distribution

The performance of quantum key distribution (QKD) is heavily dependent on the physical properties of the channel over which it is executed. Propagation losses and perturbations in the encoded photons' degrees of freedom, such as polarisation or phase, limit both the QKD range and key rate. The maintenance of phase coherence over optical fibres has lately received considerable attention as it enables QKD over long distances, e.g., through phase-based protocols like Twin-Field (TF) QKD. While optical single mode fibres (SMFs) are the current standard type of fibre, recent hollow core fibres (HCFs) could become a superior alternative in the future. Whereas the co-existence of quantum and classical signals in HCF has already been demonstrated, the phase noise resilience required for phase-based QKD protocols is yet to be established. This work explores the behaviour of HCF with respect to phase noise for the purpose of TF-QKD-like protocols. To achieve this, two experiments are performed. The first, is a set of concurrent measurements on 2 km of HCF and SMF in a double asymmetric Mach-Zehnder interferometer configuration. The second, uses a TF-QKD interferometer consisting of HCF and SMF channels. These initial results indicate that HCF is suitable for use in TF-QKD and other phase-based QKD protocols

Osmoregulators proline and glycine betaine counteract salinity stress in canola

Salt inundation leads to increased salinization of arable land in many arid and semi-arid regions. Until genetic solutions are found farmers and growers must either abandon salt-affected fields or use agronomic treatments that alleviate salt stress symptoms. Here, field experiments were carried out to study the effect of the osmoregulators proline at 200 mg L-1 and glycine betaine at 400 mg L-1 in counteracting the harmful effect of soil salinity stress on canola plants grown in Egypt. We assessed growth characteristics, yield and biochemical constituents. Results show first that all growth characters decreased with increasing salinity stress but applied osmoregulators alleviated these negative effects. Second, salinity stress decreased photosynthetic pigments, K and P contents, whilst increasing proline, soluble sugars, ascorbic acid, Na and Cl contents. Third, application of osmoregulators without salt stress increased photosynthetic pigments, proline, soluble sugars, N, K and P contents whilst decreasing Na and Cl contents. It is concluded that the exogenously applied osmoregulators glycine betaine and proline can fully or partially counteract the harmful effect of salinity stress on growth and yield of canola.© INRA and Springer-Verlag, France 2012

Design development and implementation of an irradiation station at the neutron time-of-flight facility at CERN

A new parasitic, mixed-field, neutron-dominated irradiation station has been recently commissioned at the European Laboratory for Particle Physics (CERN). The station is installed within the neutron time-of-flight (n_TOF) facility, taking advantage of the secondary radiation produced by the neutron spallation target, with neutrons ranging from 0.025 eV to several hundreds of MeV. The new station allows radiation damage studies to be performed in irradiation conditions that are closer to the ones encountered during the operation of particle accelerators; the irradiation tests carried out in the station will be complementary to the standard tests on materials, usually performed with gamma sources. Samples will be exposed to neutron-dominated doses in the MGy range per year, with minimal impact on the n_TOF facility operation. The station has 24 irradiation positions, each hosting up to 100 cm3 of sample material. In view of its proximity to the n_TOF target, inside protective shielding, the irradiation station and its operating procedures have been carefully developed taking into account the safety of personnel and to avoid any unwanted impact on the operation of the n_TOF facility and experiments. Due to the residual radioactivity of the whole area around the n_TOF target and of the irradiated samples, access to the irradiation station is forbidden to human operators even when the n_TOF facility is not in operation. Robots are used for the remote installation and retrieval of the samples, and other optimizations of the handling procedures were developed in compliance with radiation protection regulations and the aim of minimizing doses to personnel. The sample containers were designed to be radiation tolerant, compatible with remote handling, and subject to detailed risk analysis and testing during their development. The whole life cycle of the irradiated materials, including their post-irradiation examinations and final disposal, was considered and optimized