Buffer Overflow Management with Class Segregation

We consider a new model for buffer management of network switches with Quality of Service (QoS) requirements. A stream of packets, each attributed with a value representing its Class of Service (CoS), arrives over time at a network switch and demands a further transmission. The switch is equipped with multiple queues of limited capacities, where each queue stores packets of one value only. The objective is to maximize the total value of the transmitted packets (i.e., the weighted throughput). We analyze a natural greedy algorithm, GREEDY, which sends in each time step a packet with the greatest value. For general packet values $(v_1 < \cdots < v_m)$, we show that GREEDY is $(1+r)$-competitive, where $r = \max_{1\le i \le m-1} \{v_i/v_{i+1}\}$. Furthermore, we show a lower bound of $2 - v_m / \sum_{i=1}^m v_i$ on the competitiveness of any deterministic online algorithm. In the special case of two packet values (1 and $\alpha > 1$), GREEDY is shown to be optimal with a competitive ratio of $(\alpha + 2)/(\alpha + 1)$

Microfluidic fabrication of microcapsules tailored for self-healing in cementitious materials

Autonomic self-healing in cement-based infrastructure materials has recently emerged as a promising strategy for extending the service life of concrete infrastructure. Amongst the various self-healing systems being developed, the use of microcapsules has received significant attention partly because of its ease implementation. Up to date, microcapsules for self-healing applications have been mainly manufactured using bulk emulsifications polymerisation techniques. However this methodology raises concerns regarding shell dimensions and interfacial bonding. This study proposes for the first time the fabrication of microcapsules with tailored characteristics for mechanically triggered self-healing action in cement-based composites. For this, a microfluidic device was used to produce a double emulsion template for the formation of microcapsules, containing both aqueous and organic liquid core. In addition, a novel method has been proposed to functionalize the microcapsules' surface with hydrophilic groups in order to increase the interfacial bond with the cementitious host matrix. The core retention was studied using EDX and TGA, and their mechanical triggering was investigated via SEM of the microcapsules embedded in the cement paste. The results demonstrated the capability of microfluidics to produce microcapsules with liquid organic core, thin shell, hydrophilic surface and appropriate fracture strength for use in mechanically triggered self-healing of cementitious materials.CAPES (Brazilian funding) and EPSR

Neutralisation of SARS-CoV-2 lineage P.1 by antibodies elicited through natural SARS-CoV-2 infection or vaccination with an inactivated SARS-CoV-2 vaccine: An immunological study

BACKGROUND: Mutations accrued by SARS-CoV-2 lineage P.1-first detected in Brazil in early January, 2021-include amino acid changes in the receptor-binding domain of the viral spike protein that also are reported in other variants of concern, including B.1.1.7 and B.1.351. We aimed to investigate whether isolates of wild-type P.1 lineage SARS-CoV-2 can escape from neutralising antibodies generated by a polyclonal immune response. METHODS: We did an immunological study to assess the neutralising effects of antibodies on lineage P.1 and lineage B isolates of SARS-CoV-2, using plasma samples from patients previously infected with or vaccinated against SARS-CoV-2. Two specimens (P.1/28 and P.1/30) containing SARS-CoV-2 lineage P.1 (as confirmed by viral genome sequencing) were obtained from nasopharyngeal and bronchoalveolar lavage samples collected from patients in Manaus, Brazil, and compared against an isolate of SARS-CoV-2 lineage B (SARS.CoV2/SP02.2020) recovered from a patient in Brazil in February, 2020. Isolates were incubated with plasma samples from 21 blood donors who had previously had COVID-19 and from a total of 53 recipients of the chemically inactivated SARS-CoV-2 vaccine CoronaVac: 18 individuals after receipt of a single dose and an additional 20 individuals (38 in total) after receipt of two doses (collected 17-38 days after the most recent dose); and 15 individuals who received two doses during the phase 3 trial of the vaccine (collected 134-230 days after the second dose). Antibody neutralisation of P.1/28, P.1/30, and B isolates by plasma samples were compared in terms of median virus neutralisation titre (VNT FINDINGS: In terms of VNT INTERPRETATION: SARS-CoV-2 lineage P.1 might escape neutralisation by antibodies generated in response to polyclonal stimulation against previously circulating variants of SARS-CoV-2. Continuous genomic surveillance of SARS-CoV-2 combined with antibody neutralisation assays could help to guide national immunisation programmes. FUNDING: São Paulo Research Foundation, Brazilian Ministry of Science, Technology and Innovation and Funding Authority for Studies, Medical Research Council, National Council for Scientific and Technological Development, National Institutes of Health. TRANSLATION: For the Portuguese translation of the abstract see Supplementary Materials section

First UK field application and performance of microcapsule-based self-healing concrete

Maintaining the health and reliability of our infrastructure is of strategic importance. The current state of the UK infrastructure, and the associated huge costs of inspection, maintenance, repair and eventual replacement, is not sustainable and is no longer environmentally viable. The design of infrastructure, mainly concrete, remains traditional and poor material performance continues to be the main cause of deterioration and failure in our infrastructure systems. Biomimetic materials, that emulate natural biological systems in their ability to self-healing, provide an exciting and plausible solution. Embedding cementitious materials with in-built capabilities to sense and respond to their environmental triggers could potentially eliminate all external interventions and deliver a resilience infrastructure. The work presented in this paper forms part of a national initiative that has been developing biomimetic cementitious infrastructure materials which culminated in the first large-scale field trials of self-healing concrete in the UK testing four different but complementary technologies that were developed. This paper focuses on one self-healing technology, namely microcapsules, which contain a healing agent that is released on their rupture as a result of crack propagation. The paper will present details of the microcapsules used, their implementation in concrete and in the field trials and time-related, field and laboratory, assessment of the self-healing process. It also highlights challenges faced and improvements that are now on-going to produce the next generation of the microcapsule self-healing cementitious system

Microalgal Growth in Paper Industry Effluent: Coupling Biomass Production with Nutrients Removal

Paper and pulp industries produce effluents with high phosphorus concentrations, which need to be treated before their discharge in watercourses. The use of microalgae for this purpose has attracted the attention of researchers because: (i) microalgae can assimilate phosphorus (one of the main nutrients for their growth); and (ii) growing on effluents can significantly reduce the costs and environmental impact of microalgal biomass production. This study evaluated the growth and ability of Chlorella vulgaris to remove the phosphorus from a secondary-treated effluent of a Portuguese paper company. Batch experiments were performed for 11 days using different dilutions of the effluent to evaluate its inhibitory effect on microalgae. Results showed that the non-diluted effluent inhibited microalgal growth, indicating that this bioremediation process is possible after a previous dilution of the effluent. Regarding phosphorus removal, promising results were achieved, especially in the experiments conducted with the most diluted effluent: removal efficiencies obtained in these conditions were (54 +/- 1)%. Another interesting finding of this study was microalgal growth in flakes' form (mainly due to the compounds present in the effluent and to the pH values achieved), which can be an important economic advantage for biomass recovery after the remediation step

Complex coastal change in response to autogenic basin infilling: An example from a sub-tropical Holocene strandplain

Thick bay-fill sequences that often culminate in strandplain development serve as important sedimentary archives of land-ocean interaction, although distinguishing between internal and external forcings is an ongoing challenge. This study employs sediment cores, ground-penetrating radar surveys, radiocarbon dates, palaeogeographic reconstructions and hydrodynamic modelling to explore the role of autogenic processes - notably a reduction in wave energy in response to coastal embayment infilling - in coastal evolution and shoreline morphodynamics. Following a regional 2 to 4m highstand at ca 58ka, the 75km(2) Tijucas Strandplain in southern Brazil built from fluvial sediments deposited into a semi-enclosed bay. Holocene regressive deposits are underlain by fluvial sands and a Pleistocene transgressive-regressive sequence, and backed by a highstand barrier-island. The strandplain is immediately underlain by 5 to 16m of seaward-thickening, fluvially derived, Holocene-age, basin-fill mud. Several trends are observed from the landward (oldest) to the seaward (youngest) sections of the strandplain: (i) the upper shoreface and foreshore become finer and thinner and shift from sand-dominated to mud-dominated; (ii) beachface slopes decrease from \u3e11 degrees to ca 7 degrees; and (iii) progradation rates increase from 04 to 18myr(-1). Hydrodynamic modelling demonstrates a correlation between progressive shoaling of Tijucas Bay driven by sea-level fall and sediment infilling and a decrease in onshore wave-energy transport from 18 to 4kWm(-1). The combination of allogenic (sediment supply, falling relative sea-level and geology) and autogenic (decrease in wave energy due to bay shoaling) processes drove the development of a regressive system with characteristics that are rare, if not unique, in the Holocene and rock records. These findings demonstrate the complexities in architecture styles of highstand and regressive systems tracts. Furthermore, this article highlights the diverse internal and external processes and feedbacks responsible for the development of these intricate marginal marine sedimentary systems

Production of bacteriocin-like inhibitory substances (BLIS) by Bifidobacterium lactis using whey as a substrate

The objective of this work was to evaluate the production of bacteriocin-like inhibitory substances (BLIS) by Bifidobacterium animalis subsp. lactis in whey supplemented with yeast extract, inulin, Tween 80 or L-cysteine. Cell growth, acidification, glucose and lactose consumption as well as BLIS production were measured during fermentations carried out in shake flasks. The best additive for both cell growth and BLIS production was shown to be yeast extract, which gave the highest concentrations of biomass (9.9 log CFU/mL) and BLIS (800 AU/mL). In a bench-scale fermenter, B. lactis growth and BLIS production were between 6 and 25 % higher than in flasks depending on the conditions assayed

Numerical Analysis of a Swirl Stabilized Premixed Combustor with the Flamelet Generated Manifold approach

In this paper the effectiveness of LES for modeling premixed methane combustion will be investigated in the context of gas turbine modeling. The required reduction of the chemistry is provided by the flamelet generated manifold (FGM) approach of van Oijen (2002). For turbulence-chemistry interactions an algebraic model is used to calculate variations which are used to invoke a pre-assumed pdf, Vreman et al. (2009). The algebraic model has a tunable parameter