A randomized trial of nebulized 3% hypertonic saline with salbutamol in the treatment of acute bronchiolitis in hospitalized infants

OBJECTIVE: Acute bronchiolitis is a common disorder of infants that often results in hospitalization. Apart from supportive care, no therapy has been shown to influence the course of the disease, except for a possible effect of nebulized hypertonic saline (HS). To determine whether this does have beneficial effects on length of stay in hospital or on severity scores, we undertook a double-blind, randomized, controlled trial in a pediatric department of a Portuguese hospital. METHODS: Previously healthy infants, younger than 12 months, hospitalized with mild-to-moderate acute viral bronchiolitis were randomized to receive either nebulized 3% (hypertonic, HS) or 0.9% (normal, NS) saline during their entire hospital stay. Primary endpoints were: length of hospital stay and severity scores on each day of hospitalization. Need for supplemental oxygen, further add-on medications and adverse effects were also analyzed. RESULTS: Sixty-eight patients completed the study (HS: 33; NS: 35). The median length of hospital stay did not differ between groups: HS: 5.6 ± 2.3 days; NS: 5.4 ± 2.1 days (P = 0.747). We found no difference between groups in severity scores from day 1 to day 4. There were no differences in need for supplemental oxygen or add-on medications. Patients in HS group had significantly more cough (46% vs. 20%, P = 0.025) and rhinorrhoe (58% vs. 31%, P = 0.30). CONCLUSION: This study does not support the use of nebulized HS over NS in therapy of hospitalized children with mild-to-moderate acute viral bronchioliti

How can the recall of early affiliative memories with peers influence on disordered eating behaviours?

The present study aimed to explore the role of early affiliative memories with peers on the adoption of disordered eating attitudes and behaviours through the mechanisms of external shame and self-judgment. The sample used in the current study comprised 632 women from the community, aged between 18 and 60 years old. The tested model explained 22% of eating psychopathology’s variance and showed excellent model fit indices. Results indicated that the impact of the recall of early positive memories with peers on eating psychopathology was fully carried through the mechanisms of external shame and self-judgment. In fact, these findings seem to suggest that the lack of warm and safe affiliative memories with peers is linked with higher levels of shame (e.g., feelings of inferiority and inadequacy), and also with higher vulnerability to engage in maladaptive emotional strategies (such as self-judgmental attitudes), which appears to explain the increase of disordered eating behaviours. These findings contribute to the understanding of the impact of peer-related early affiliative memories on the engagement in disordered eating. Furthermore, this study has significant clinical implications, emphasizing the importance of targeting shame and maladaptive emotional strategies, especially in a context involving early adverse emotional experiences with peers

Do shame and perfectionistic self-presentation explain the link between early affiliative memories and eating psychopathology?

This study explored a model examining the impact that early affiliative memories (with family and peers) presents on eating psychopathology, and whether this link is carried by the mechanisms of external shame and body image-related perfectionistic self-presentation. This study’s sample comprised 480 female college students, who completed the self-report measures of interest. Path analyses’ results revealed that this model accounted for 48% of disordered eating’s variance. Furthermore, results showed that 26% of external shame was explained by early memories of warmth and safeness, and that 19% of body image-related perfectionistic self-presentation was explained by the lack of recall of these affiliative memories, through increased levels of external shame. These findings seem to suggest that the lack of these positive memories is associated with higher levels of shame (feelings of inferiority and unattractiveness), and with higher tendencies to adopt body image-related perfectionistic strategies, that seem to explain excessive eating concern and rigid control of one’s eating behaviours. This study offers important insights for future research and for the development of intervention programs, by revealing the importance of assessing and targeting shame and perfectionistic strategies and suggesting the importance of promoting adaptive emotion regulation strategies to deal with adverse memories

Understanding Refugees\u27 Perspectives on Health Care

Introduction. Burlington, Vermont accepts refugees from around the world. These individuals face unique barriers to accessing healthcare due to language, culture and finances. Research suggests that cultural beliefs about healthcare can affect ability or willingness to seek medical care. Gaining a better understanding of refugee perspectives of the healthcare system may offer insight into how to rectify this issue. Objectives. The goal of this study was to learn about refugee perspectives of the healthcare system and assess their use of services. Methods. We surveyed a convenience sample of 24 refugees to learn more about thoughts and practices surrounding healthcare and the use of the medical system. Results. Survey findings suggested that refugees who had been living in the US for longer than one year access healthcare resources differently from more recent arrivals. Most respondents agreed that reasons for going to a healthcare provider revolved around the diagnosis and treatment of current ailments. Regardless of time spent in the U.S., most respondents were unlikely to seek out preventive care. Refugees who had been in the U.S. longer than one year were less likely to seek out emergency services for acute symptoms that would be better served by a visit with their PCP. Conclusions. Recent arrivals used the emergency room for primary care needs more than those living in the U.S. longer than one year, suggesting the efficacy of provided health education. Study data suggests an important area for improvement may be increased education for refugees about the importance of preventive care.https://scholarworks.uvm.edu/comphp_gallery/1250/thumbnail.jp

Scattering from supramacromolecular structures

We study theoretically the scattering imprint of a number of branched supramacromolecular architectures, namely, polydisperse stars and dendrimeric, hyperbranched structures. We show that polydispersity and nature of branching highly influence the intermediate wavevector region of the scattering structure factor, thus providing insight into the morphology of different aggregates formed in polymer solutions.Comment: 20 pages, 8 figures To appear in PR

Association Between Glycated Albumin, Fructosamine, and HbA1c with Neonatal Outcomes in a Prospective Cohort of Women with Gestational Diabetes Mellitus

Objective: To investigate whether glycated albumin, fructosamine, and hemoglobin A1c (HbA1c) are associated with neonatal complications in newborns of pregnant women with gestational diabetes mellitus (GDM). Methods: Between November 2016 and September 2017, women with a singleton pregnancy and GDM were enrolled in a prospective study in an obstetric Portuguese referral center. Glycemic markers were compared between mothers of newborns with and without complications. Multivariable logistic regression models and corresponding areas under the receiver operating characteristic curve (AUC) were used. Results: A total of 85 women participated in the study. Raised levels of glycated albumin and fructosamine were associated with at least one neonatal complication (OR- [odds ratio] estimate: 1.33, P=0.015; OR: 1.24, P=0.027, respectively) and with respiratory disorders at birth (OR 1.41, P=0.004; OR 1.26, P=0.014, respectively). HbA1c was not associated with these outcomes. All biomarkers were associated with large-for-gestational age (LGA) status (OR 1.61, P<0.001; OR 1.45, P<0.001; OR 3.62, P=0.032 for glycated albumin, fructosamine, and HbA1c, respectively). All had similar AUC for at least one neonatal complication (0.82; 0.81; 0.79, respectively). For newborn respiratory disorders, AUCs were 0.83, 0.81, and 0.76, respectively, and for LGA status were 0.81, 0.79, and 0.71, respectively. Conclusion: Raised values of glycated albumin and fructosamine were associated with particular perinatal complications in newborns of mothers with GDM, better discriminating mothers of newborns with and without complications than HbA1c.info:eu-repo/semantics/publishedVersio

Zebrafish xenografts as a fast screening platform for bevacizumab cancer therapy

Cancer is the second leading cause of death in the world. Given that cancer is a highly individualized disease, predicting the best chemotherapeutic treatment for individual patients can be difficult. Ex vivo models such as mouse patient-derived xenografts (PDX) and organoids are being developed to predict patient-specific chemosensitivity profiles before treatment in the clinic. Although promising, these models have significant disadvantages including long growth times that introduce genetic and epigenetic changes to the tumor. The zebrafish xenograft assay is ideal for personalized medicine. Imaging of the small, transparent fry is unparalleled among vertebrate organisms. In addition, the speed (5-7 days) and small patient tissue requirements (100-200 cells per animal) are unique features of the zebrafish xenograft model that enable patient-specific chemosensitivity analyses.info:eu-repo/semantics/publishedVersio