The Effectiveness of an Interactive WhatsApp Bot on Listening Skills

The present paper attempted to measure the effectiveness of an interactive WhatsApp bot on the listening skills of Omani English as a Foreign Language (EFL) learners. For this purpose, 40 Omani intermediate EFL learners were divided into two groups: a control and an experimental in a higher education institution. A pretest was conducted to ensure the homogeneity of listening skills among all the participants. While both groups received instructions and exercises on listening in class, an interactive WhatsApp bot was designed for the experimental group to receive more instructions and training without time and place limitations. Later, a posttest and a delayed posttest were conducted to compare learners’ performance. The study results showed smooth progress of both groups in listening exams during the posttest and delayed posttest; however, the experimental group’s performance was significantly high. The findings of the study are efficacious and helpful for teachers and learners

THE EFFECT OF TEACHING PUNCTUATION MARKS EXPLICITLY ON OMANI EFL LEARNERS WRITING ABILITIES

This is a research study about teaching punctuation marks explicitly and its effects on EFL learners` writing abilities. To do this, 40 Omani EFL learners at intermediate level from Sohar College of Applied Sciences, Oman were selected. Ministerial placement test homogenized students according to their level of proficiency. A pretest was applied to ensure students similar knowledge on the basis of punctuation marks. Then, treatment was provided for the experimental group of learners and finally another writing test as a posttest was applied to measure the results. Results revealed that teaching punctuation marks explicitly doesn’t have any effect on the learners` writing abilities in that college.  Article visualizations

Omani EFL learner perceptions and motivation toward online learning

In early 2020, with the breakout of COVID-19, almost all the world institutions shifted to online learning and teaching. Besides the shortcomings, new learning and teaching method was introduced globally. 48 Omani participants of this study were the first batch of learners who have experienced online learning and teaching for the first time in their life. Therefore, this study tried to understand their levels of motivation and perceptions of online learning. The study also tried to find out the gender difference and the motivational level among the participants. Participants were sent two questionnaires through the Google form, and their responses were analyzed accordingly. The study revealed that Omani students were motivated to exchange learning and teaching materials through online platforms, and the female ones showed slightly more interest in online classes. In addition, the students showed positive perceptions toward and willingness to continue using online platforms for the learning process. Since they are the first group of students with online learning experiences, the study can motivate the teachers to focus on more digital contexts of their study, help them to focus on the design and preparation of materials for the digital community, and curriculum developers can introduce more practical learning and teaching techniques suitable for online education

Evaluation of the metaphorical image in architecture

The metaphorical image represented in the architectural works was subjected to evaluation by different social sectors perceiving them in the society. Despite the diversity in the studies related to metaphorical image. In addition, the special standards forwarded for metaphorical image were dependent on selective formula as they were conjugated with the cultural context to which the critic belongs giving such interpretations. These studies.could not formulate a theoretical framework comprised cultural contexts. Its methodology concentrated ontheconstructionof atheoretical framework, the isolation of the variables related its main aspects, the clarification of its measurements and the performance of a selected field study which includes the main aspects of the evaluation process. This papers aims to determine and describe factors influencing evaluation of the metaphorical image in architecture according to certain architectural patterns to specimen from Iraqi environment. The framework included aspects represented by the metaphorical process, perception and evaluation. Using a special methodology the research hypotheses were checked and the data were processed using the computer software SPSS for statistical analysis

LC–MS/MS-based in vitro and in vivo Investigation of Blood–brain Barrier Integrity by Simultaneous Quantitation of Mannitol and Sucrose

Background Understanding the pathophysiology of the blood brain–barrier (BBB) plays a critical role in diagnosis and treatment of disease conditions. Applying a sensitive and specific LC–MS/MS technique for the measurement of BBB integrity with high precision, we have recently introduced non-radioactive [13C12]sucrose as a superior marker substance. Comparison of permeability markers with different molecular weight, but otherwise similar physicochemical properties, can provide insights into the uptake mechanism at the BBB. Mannitol is a small hydrophilic, uncharged molecule that is half the size of sucrose. Previously only radioactive [3H]mannitol or [14C]mannitol has been used to measure BBB integrity. Methods We developed a UPLC–MS/MS method for simultaneous analysis of stable isotope-labeled sucrose and mannitol. The in vivo BBB permeability of [13C6]mannitol and [13C12]sucrose was measured in mice, using [13C6]sucrose as a vascular marker to correct for brain intravascular content. Moreover, a Transwell model with induced pluripotent stem cell-derived brain endothelial cells was used to measure the permeability coefficient of sucrose and mannitol in vitro both under control and compromised (in the presence of IL-1β) conditions. Results We found low permeability values for both mannitol and sucrose in vitro (permeability coefficients of 4.99 ± 0.152 × 10−7 and 3.12 ± 0.176 × 10−7 cm/s, respectively) and in vivo (PS products of 0.267 ± 0.021 and 0.126 ± 0.025 µl g−1 min−1, respectively). Further, the in vitro permeability of both markers substantially increased in the presence of IL-1β. Corrected brain concentrations (Cbr), obtained by washout vs. vascular marker correction, were not significantly different for either mannitol (0.071 ± 0.007 and 0.065 ± 0.009 percent injected dose per g) or sucrose (0.035 ± 0.003 and 0.037 ± 0.005 percent injected dose per g). These data also indicate that Cbr and PS product values of mannitol were about twice the corresponding values of sucrose. Conclusions We established a highly sensitive, specific and reproducible approach to simultaneously measure the BBB permeability of two classical low molecular weight, hydrophilic markers in a stable isotope labeled format. This method is now available as a tool to quantify BBB permeability in vitro and in vivo in different disease models, as well as for monitoring treatment outcomes

Characterization of Raman gain for different gain medium

By using different fiber types as gain medium such as 500 m HNLF, 215 cm Bi-EDF, 7.2 km DCF, 11 km DCF, 18.2 km DCF, as well as the composition of Bi-EDF with 11 km DCF and finally the composition of Bi-EDF with the 18.2 km DCF, Raman gain was characterized and measured by the same set up as proposed in our study. The results revealed that the composition of Bi-EDF with the 18.2 km DCF provided the highest effective Raman gain among the other fibers investigated

Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning

In the present paper, we have investigated early pathophysiological events in graft-versus-host disease (GVHD), a major complication to hematopoietic stem cell transplantation (HSCT). BLLB/c female mice conditioned with busulfan/cyclophosphamide (Bu-Cy) were transplanted with allogeneic male C57BL/6. Control group consisted of syngeneic transplanted Balb/c mice. In allogeneic settings, significant expansion and maturation of donor dendritic cells (DCs) were observed at day +3, while donor T-cells CD8+ were increased at day +5 (230%) compared to syngeneic HSCT. Highest levels of inflammatory cytokines IL-2, IFN-gamma, and TNF-alfa at day +5 matched T-cell activation. Concomitantly naïve T-cells gain effecr-memory phenotype and migrated from spleen to peripheral lymphoid organs. Thus, in the very early phase of GHVD following Bu-Cy conditioning donor, DCs play an important role in the activation of donor T cells. Subsequently, donor naïve T-cells gain effector-memory phenotype and initiate GVHD

Graphene oxide-fullerene nanocomposite laminates for efficient hydrogen purification

Graphene oxide (GO) with its unique two-dimensional structure offers an emerging platform for designing advanced gas separation membranes that allow for highly selective transport of hydrogen molecules. Nevertheless, further tuning of the interlayer spacing of GO laminates and its effect on membrane separation efficiency remains to be explored. Here, positively charged fullerene C₆₀ derivatives are electrostatically bonded to the surface of GO sheets in order to manipulate the interlayer spacing between GO nanolaminates. The as-prepared GO-C₆₀ membranes have a high H₂ permeance of 3370 GPU (gas permeance units) and an H₂/CO₂ selectivity of 59. The gas separation selectivity is almost twice that of flat GO membranes because of the role of fullerene

Multipath Routing in Wireless Sensor Networks: Survey and Research Challenges

A wireless sensor network is a large collection of sensor nodes with limited power supply and constrained computational capability. Due to the restricted communication range and high density of sensor nodes, packet forwarding in sensor networks is usually performed through multi-hop data transmission. Therefore, routing in wireless sensor networks has been considered an important field of research over the past decade. Nowadays, multipath routing approach is widely used in wireless sensor networks to improve network performance through efficient utilization of available network resources. Accordingly, the main aim of this survey is to present the concept of the multipath routing approach and its fundamental challenges, as well as the basic motivations for utilizing this technique in wireless sensor networks. In addition, we present a comprehensive taxonomy on the existing multipath routing protocols, which are especially designed for wireless sensor networks. We highlight the primary motivation behind the development of each protocol category and explain the operation of different protocols in detail, with emphasis on their advantages and disadvantages. Furthermore, this paper compares and summarizes the state-of-the-art multipath routing techniques from the network application point of view. Finally, we identify open issues for further research in the development of multipath routing protocols for wireless sensor networks

A Syrian Refugee in Iraq Diagnosed as a Case of IL12RB1 Deficiency in Japan Using Dried Blood Spots

Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare condition of primary immunodeficiency disorder. Interleukin-12 receptor β1 (IL12RB1) deficiency, is the most common genetic etiology of MSMD, which is characterized by the selective predisposition to clinical disease caused by weakly-virulent mycobacteria, such as Bacillus Calmette-Guérin (BCG) vaccines, and environmental non-tuberculous mycobacteria (NTM). To the best of our knowledge, this is the first case of IL12RB1 deficiency to be reported from Iraq. Our case is an 8-year-old Syrian girl, for first-cousin parents, with a refugee-status in the North of Iraq. She had a history of disseminated BCG infection 2 months after receiving BCG vaccine, in addition to repeated episodes of mild or severe illnesses, such as maculopapular skin rash, lymphadenopathy, gastroenteritis, meningitis, and clinically diagnosed tuberculosis (TB) based on local TB-prevalence setting. Because of limited medical facilities in the war-torn countries; in Syria and Iraq, no diagnosis could be reached. We used Flinders Technology Associates (FTA) cards to transfer her bone marrow aspirate to Japan. A homozygous IL12RB1 mutation was detected by whole exome sequencing in Japan, using genomic-DNA extracted from dried bone marrow sample spots on FTA filter paper. In conclusion, diagnosis of MSMD due to IL12RB1 deficiency was possible by transferring the FTA sample of the patient for genetic evaluation in Japan. Our report recalls the need of pediatricians in countries with TB-prevalence and high parental consanguinity, to consider IL12RB1 deficiency in the differential diagnosis of a child with clinical evidence of TB, especially with the history of disseminated BCG disease