Life-threatening parkinsonism-hyperpyrexia syndrome following bilateral deep brain stimulation of the subthalamic nucleus

Parkinsonism-hyperpyrexia syndrome (PHS), or neuroleptic malignant syndrome (NMS), is a neurophysiologic reaction to the acute withdrawal/decrease of central dopamine levels. It is a severe complication characterized by rigidity, change in consciousness level, fever, hypertension, and autonomic instability, that can be fatal. To the best of our knowledge, PHS following deep brain stimulation (DBS) of subthalamic nucleus (STN) surgery due to anti-Parkinson drug discontinuation has been previously reported only six times. Half of these cases resulted in fatalities. Herein, we report on an early diagnosed case of PHS following bilateral STN-DBS which was successfully treated with the administration of dopamine agonists, fluid replacement, and activation of DBS

Idiopathic Intracranial Hypertension: Diagnosis and Therapeutic Approach

İdiyopatik intrakraniyal hipertansiyon (İİH) sekonder bir nedene bağlı olmayan kafa içi basınç artışıdır. Sıklıkla genç ve obez kadınlarda görülür. Baş ağrısı, görme problemleri ve pulsatil kulak çınlaması hastaları en çok hekime götüren şikayetlerdir. İİH heterojen bulgu ve belirtileri nedeniyle aile hekimlerini ve birçok branşı birlikte ilgilendirmektedir. Tedavisi gecikirse kalıcı morbidite yaratan bu hastalıkta her olgu için kişiye özgü bir tedavi planlanmalıdır. Bu yazıda son yayınlar çerçevesinde İİH'nin etiyopatogenezi ile birlikte tanı ve tedavisi gözden geçirilmiştirIdiopathic intracranial hypertension (IIH) is a condition of increased intracranial pressure without a secondary etiology. IIH is seen frequently in young and obese women. Headache, vision problems, and pulsatile tinnitus are the most common symptoms that lead patients to physicians. IIH requires a multidisciplinary approach because it could create permanent morbidity and its treatment plan should be individualized for each patient. The aim of this review was to provide an updated overview of IIH’s pathogenesis, diagnostic criteria, and treatment strategie

Chiari Type I malformation yielded to the diagnosis of Crouzon syndrome

Chiari malformation Type I (CM-I) related to syndromic craniosynostosis in pediatric patients has been well-studied. The surgical management consists of cranial vault remodeling with or without posterior fossa decompression. There were also cases, in whom CM-I was diagnosed prior to the craniosynostosis in early childhood. We present a 16-year-old boy who admitted with symptoms related to CM-I. With careful examination and further genetic investigations, a diagnosis of Crouzon syndrome was made, of which the patient and his family was unaware before. The patient underwent surgery for posterior fossa decompression and followed-up for Crouzon’s syndrome. To our knowledge, this is the only case report indicating a late adolescent diagnosis of Crouzon syndrome through clinical symptoms of an associated CM-I

Dev Rathke Kleft Kistleri. İki Olgu Sunumu

Embriyonel gelişim döneminin bir defekti sonucu ortaya çıktığı bilinen Rathke Kleft Kisti, erişkin döneme kadar asemptomatik olarak kalabilir. Farklı klinik davranışları olan, radyolojik olarak tanı konulan ve lezyonun boyutlarına göre değişen tedavi seçenekleri tercih edilebilen, görme bozukluğu ve başağrısı ile başvuran 34 ve 62 yaşlarındaki iki bayan olgumuzu literatür bilgileri ışığında inceledik.Rathke cleft cysts, known to result from defects during the embryological development period, may remain asymptomatic until adulthood. Herein we report 34 and 62 years old two female patients with Rathke cleft cysts, who admitted with visual problems and headache. The different clinical behaviors and the treatment options which may vary according to the lesion size of the radiologically diagnosed cysts were discussed in the light of the current literature