95 research outputs found

    Network electro-thermal simulation of non-isothermal magnetohydrodynamic heat transfer from a transpiring cone with buoyancy and pressure work

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    The steady, axisymmetric laminar natural convection boundary layer flow from a non-isothermal vertical circular porous cone under a transverse magnetic field, with the cone vertex located at the base, is considered. The pressure work effect is included in the analysis. The governing boundary layer equations are formulated in an (x,y) coordinate system (parallel and normal to the cone slant surface), and the magnetic field effects are simulated with a hydromagnetic body force term in the momentum equation. A dimensionless transformation is performed rendering the momentum and also heat conservation equations. The thermal convection flow is shown to be controlled by six thermophysical parameters- local Hartmann number, local Grashof number, pressure work parameter, temperature power law exponent, Prandtl number and the transpiration parameter. The transformed parabolic partial differential equations are solved numerically using the Network Simulation Method (NSM) based on the electrical-thermodynamic analogy. Excellent correlation of the zero Hartmann number case is achieved with earlier electrically non-conducting solutions. Local shear stress function (skin friction) is found to be strongly decreased with an increase in Prandtl number (Pr), with negative values (corresponding to flow reversal) identified for highest Pr with further distance along the streamwise direction. A rise in local Hartmann number, is observed to depress skin friction. Increasing temperature power law index, corresponding to steeper temperature gradient at the wall, strongly reduces skin friction at the cone surface. A positive rise in pressure work parameter decreases skin friction whereas a negative increase elevates the skin friction for some distance along the cone surface from the apex. Local heat transfer gradient is markedly boosted with a rise in Prandtl number but decreased principally at the cone surface with increasing local Hartmann number. Increasing temperature power law index conversely increases the local heat transfer gradient, at the cone surface. A positive rise in pressure work parameter increases local heat transfer gradient while negative causes it to decrease. A rise in local Grashof number boosts local skin friction and velocity into the boundary layer; local heat transfer gradient is also increased with a rise in local Grashof number whereas the temperature in the boundary layer is noticeably reduced. Applications of the work arise in spacecraft magnetogas dynamics, chemical cooling systems and industrial magnetic materials processing

    Genome Wide Association Identifies PPFIA1 as a Candidate Gene for Acute Lung Injury Risk Following Major Trauma

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    Acute Lung Injury (ALI) is a syndrome with high associated mortality characterized by severe hypoxemia and pulmonary infiltrates in patients with critical illness. We conducted the first investigation to use the genome wide association (GWA) approach to identify putative risk variants for ALI. Genome wide genotyping was performed using the Illumina Human Quad 610 BeadChip. We performed a two-stage GWA study followed by a third stage of functional characterization. In the discovery phase (Phase 1), we compared 600 European American trauma-associated ALI cases with 2266 European American population-based controls. We carried forward the top 1% of single nucleotide polymorphisms (SNPs) at p<0.01 to a replication phase (Phase 2) comprised of a nested case-control design sample of 212 trauma-associated ALI cases and 283 at-risk trauma non-ALI controls from ongoing cohort studies. SNPs that replicated at the 0.05 level in Phase 2 were subject to functional validation (Phase 3) using expression quantitative trait loci (eQTL) analyses in stimulated B-lymphoblastoid cell lines (B-LCL) in family trios. 159 SNPs from the discovery phase replicated in Phase 2, including loci with prior evidence for a role in ALI pathogenesis. Functional evaluation of these replicated SNPs revealed rs471931 on 11q13.3 to exert a cis-regulatory effect on mRNA expression in the PPFIA1 gene (p = 0.0021). PPFIA1 encodes liprin alpha, a protein involved in cell adhesion, integrin expression, and cell-matrix interactions. This study supports the feasibility of future multi-center GWA investigations of ALI risk, and identifies PPFIA1 as a potential functional candidate ALI risk gene for future research

    A Search for Extragalactic Fast Blue Optical Transients in ZTF and the Rate of AT2018cow-like Transients

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    We present a search for extragalactic fast blue optical transients (FBOTs) during Phase I of the Zwicky Transient Facility (ZTF). We identify 38 candidates with durations above half-maximum light 1 day < t1/2 < 12 days, of which 28 have blue (g − r ≲ −0.2 mag) colors at peak light. Of the 38 transients (28 FBOTs), 19 (13) can be spectroscopically classified as core-collapse supernovae (SNe): 11 (8) H- or He-rich (Type II/IIb/Ib) SNe, 6 (4) interacting (Type IIn/Ibn) SNe, and 2 (1) H&He-poor (Type Ic/Ic-BL) SNe. Two FBOTs (published previously) had predominantly featureless spectra and luminous radio emission: AT2018lug (The Koala) and AT2020xnd (The Camel). Seven (five) did not have a definitive classification: AT 2020bdh showed tentative broad Hα in emission, and AT 2020bot showed unidentified broad features and was 10 kpc offset from the center of an early-type galaxy. Ten (eight) have no spectroscopic observations or redshift measurements. We present multiwavelength (radio, millimeter, and/or X-ray) observations for five FBOTs (three Type Ibn, one Type IIn/Ibn, one Type IIb). Additionally, we search radio-survey (VLA and ASKAP) data to set limits on the presence of radio emission for 24 of the transients. All X-ray and radio observations resulted in nondetections; we rule out AT2018cow-like X-ray and radio behavior for five FBOTs and more luminous emission (such as that seen in the Camel) for four additional FBOTs. We conclude that exotic transients similar to AT2018cow, the Koala, and the Camel represent a rare subset of FBOTs and use ZTF's SN classification experiments to measure the rate to be at most 0.1% of the local core-collapse SN rate

    Less Than 1% of Core-collapse Supernovae in the Local Universe Occur in Elliptical Galaxies

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    We present observations of three core-collapse supernovae (CCSNe) in elliptical hosts, detected by the Zwicky Transient Facility Bright Transient Survey (BTS). SN 2019ape is a SN Ic that exploded in the main body of a typical elliptical galaxy. Its properties are consistent with an explosion of a regular SN Ic progenitor. A secondary g-band light-curve peak could indicate interaction of the ejecta with circumstellar material (CSM). An Hα-emitting source at the explosion site suggests a residual local star formation origin. SN 2018fsh and SN 2020uik are SNe II which exploded in the outskirts of elliptical galaxies. SN 2020uik shows typical spectra for SNe II, while SN 2018fsh shows a boxy nebular Hα profile, a signature of CSM interaction. We combine these 3 SNe with 7 events from the literature and analyze their hosts as a sample. We present multi-wavelength photometry of the hosts, and compare this to archival photometry of all BTS hosts. Using the spectroscopically complete BTS, we conclude that 0.3%-0.1+0.3 of all CCSNe occur in elliptical galaxies. We derive star formation rates and stellar masses for the host galaxies and compare them to the properties of other SN hosts. We show that CCSNe in ellipticals have larger physical separations from their hosts compared to SNe Ia in elliptical galaxies, and discuss implications for star-forming activity in elliptical galaxies

    Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection

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