18,425 research outputs found

    Experimental investigation of non-uniform heating on flow boiling instabilities in a microchannels based heat sink

    Get PDF
    Two-phase flow boiling in microchannels is one of the most promising cooling technologies able to cope with high heat fluxes generated by the next generation of central processor units (CPU). If flow boiling is to be used as a thermal management method for high heat flux electronics it is necessary to understand the behaviour of a non-uniform heat distribution, which is typically the case observed in a real operating CPU. The work presented is an experimental study of two-phase boiling in a multi-channel silicon heat sink with non-uniform heating, using water as a cooling liquid. Thin nickel film sensors, integrated on the back side of the heat sinks were used in order to gain insight related to temperature fluctuations caused by two-phase flow instabilities under non-uniform heating. The effect of various hotspot locations on the temperature profile and pressure drop has been investigated, with hotspots located in different positions along the heat sink. It was observed that boiling inside microchannels with non-uniform heating led to high temperature non-uniformity in transverse direction

    Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia

    Get PDF
    Objective: Familial glucocorticoid deficiency type I (FGD1) is a rare form of primary adrenal insufficiency resulting from recessive mutations in the ACTH receptor (MC2R, MC2R). Individuals with this condition typically present in infancy or childhood with signs and symptoms of cortisol insufficiency, but disturbances in the renin-angiotensin system, aldosterone synthesis or sodium homeostasis are not a well-documented association of FGD1. As ACTH stimulation has been shown to stimulate aldosterone release in normal controls, and other causes of hyponatraemia can occur in children with cortisol deficiency, we investigated whether MC2R changes might be identified in children with primary adrenal failure who were being treated for mineralocorticoid insufficiency. Design: Mutational analysis of MC2R by direct sequencing. Patients: Children (n = 22) who had been diagnosed with salt-losing forms of adrenal hypoplasia (19 isolated cases, 3 familial), and who were negative for mutations in DAX1 (NR0B1) and SF1 (NR5A1). Results: MC2R mutations were found in three individuals or kindred (I: homozygous S74I; II: novel compound heterozygous R146H/560delT; III: novel homozygous 579-581delTGT). These changes represent severely disruptive loss-of-function mutations in this G-protein coupled receptor, including the first reported homozygous frameshift mutation. The apparent disturbances in sodium homeostasis were mild, manifest at times of stress (e.g. infection, salt-restriction, heat), and likely resolved with time. Conclusions: MC2R mutations should be considered in children who have primary adrenal failure with apparent mild disturbances in renin-sodium homeostasis. These children may have been misdiagnosed as having salt-losing adrenal hypoplasia. Making this diagnosis has important implications for treatment, counselling and long-term prognosi

    High Speed Photodetectors

    Get PDF
    High speed photodetectors are important for a number of applications. This work is about accurate design of uni-travelling carrier photodetectors. In particular, integrated devices with antenna for operating frequencies above 100 GHz

    Photodiodes for Terahertz Applications

    Get PDF
    Terahertz generation using high-speed photodiodes has found commercial application in many areas ranging across spectroscopy, imaging and communications. In this paper we discuss the optimization of high-speed photodiodes in terms of bandwidth and output power. We identify some of the main limitations in the generation of high output power in the Terahertz frequency band. We present a modelling tool for the numerical evaluation of antenna coupled uni-travelling carrier photodiodes and experimental evaluation of the fabricated designs. We also present a thermal analysis of the photodiodes alongside pulsed measurements of the output power saturation

    Generalized Mittag-Leffler Distributions and Processes for Applications in Astrophysics and Time Series Modeling

    Full text link
    Geometric generalized Mittag-Leffler distributions having the Laplace transform 11+βlog(1+tα),00\frac{1}{1+\beta\log(1+t^\alpha)},00 is introduced and its properties are discussed. Autoregressive processes with Mittag-Leffler and geometric generalized Mittag-Leffler marginal distributions are developed. Haubold and Mathai (2000) derived a closed form representation of the fractional kinetic equation and thermonuclear function in terms of Mittag-Leffler function. Saxena et al (2002, 2004a,b) extended the result and derived the solutions of a number of fractional kinetic equations in terms of generalized Mittag-Leffler functions. These results are useful in explaining various fundamental laws of physics. Here we develop first-order autoregressive time series models and the properties are explored. The results have applications in various areas like astrophysics, space sciences, meteorology, financial modeling and reliability modeling.Comment: 12 pages, LaTe
    corecore