2,060 research outputs found
Canonical Generations and the British Left: The Narrative Construction of the Miners’ Strike 1984–85
‘Generations’ have been invoked to describe a variety of social and cultural relationships, and to understand the development of self-conscious group identity. Equally, the term can be an applied label and politically useful construct; generations can be retrospectively produced. Drawing on the concept of ‘canonical generations’ – those whose experiences come to epitomise an event of historic and symbolic importance – this article examines the narrative creation and functions of ‘generations’ as collective memory shapes and re-shapes the desire for social change. Building a case study of the canonical role of the miners’ strike of 1984–85 in the narrative history of the British left, it examines the selective appropriation and transmission of the past in the development of political consciousness. It foregrounds the autobiographical narratives of activists who, in examining and legitimising their own actions and prospects, (re)produce a ‘generation’ in order to create a relatable and useful historical understanding
PREDICT-PD: Identifying risk of Parkinson's disease in the community: methods and baseline results
To present methods and baseline results for an online screening tool to identify increased risk for Parkinson's disease (PD) in the UK population
Psychiatric Disorder Criteria and their Application to Research in Different Racial Groups
BACKGROUND: The advent of standardized classification and assessment of psychiatric disorders, and considerable joint efforts among many countries has led to the reporting of international rates of psychiatric disorders, and inevitably, their comparison between different racial groups. RESULTS: In neurologic diseases with defined genetic etiologies, the same genetic cause has different phenotypes in different racial groups. CONCLUSION: We suggest that genetic differences between races mean that diagnostic criteria refined in one racial group, may not be directly and simply applicable to other racial groups and thus more effort needs to be expended on defining diseases in other groups. Cross-racial confounds (in addition to cultural confounds) make the interpretation of rates in different groups even more hazardous than seems to have been appreciated
Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer.
We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60's followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. Pathological examination demonstrated 4-repeat tau neuronal and glial lesions, including tufted astrocytes, consistent with a diagnosis of progressive supranuclear palsy. In addition, neurofibrillary tangles composed of mixed 3-repeat and 4-repeat tau and astrocytic tangles in a distribution highly suggestive of chronic traumatic encephalopathy were observed together with limbic TDP-43 pathology. Possible mechanisms for the co-occurrence of these two tau pathologies are discussed
The effect of phase chemistry on the extent of strengthening mechanisms in model Ni-Cr-Al-Ti-Mo based superalloys
The exceptional mechanical properties of polycrystalline nickel-based superalloys arise through various concurrent strengthening mechanisms. Whilst these mechanisms are generally understood, consensus has yet to be established on the precise contribution of each to the overall alloy strength. Furthermore, changes in alloy chemistry influence several different mechanisms, making the assessment of individual alloying elements complex. In this study, a series of model quinary Ni-based superalloys has been investigated to systematically study the effect of varying Mo content on the contributing strengthening mechanisms. Using microstructural data, the yield strength was modelled by summing the individual effects of solid solution in both the γ and γ ' phases, coherency, grain boundary and precipitation strengthening. The total predicted yield stress increased with Mo content despite the diminishing contribution of precipitation strengthening. It is shown that solid solution strengthening of the ordered γ' precipitate phase is a key contributor to the overall strength, and that variations in composition between the tertiary and secondary γ ' lead to significant changes in mechanical properties that should be accounted for in models of alloy strength.Funding was provided by the EPSRC/Rolls-Royce Strategic Partnership under EP/M005607/1 and EP/H022309/1. The Oxford Atom Probe facility was funded by the EPSRC under EP/M022803/1. E. I. Galindo-Nava would like to acknowledge the Royal Academy of Engineering for his fellowship funding. Neutron diffraction beam time was supported through the Canadian Neutron Beam Centre under Experiment number 1258
Web-based assessment of Parkinson's prodromal markers identifies GBA variants.
Identifying those “at risk” of Parkinson’s disease (PD) is a
priority and a key strategy for testing neuroprotective
agents. PREDICT-PD is a pilot cohort study in which
healthy UK adults are screened online (www.predictpd.com)
with a questionnaire that ascertains the presence of early
phenotypic features and risk factors, based on systematic
review
All-Versus-Nothing Proof of Einstein-Podolsky-Rosen Steering
Einstein-Podolsky-Rosen steering is a form of quantum nonlocality
intermediate between entanglement and Bell nonlocality. Although Schr\"odinger
already mooted the idea in 1935, steering still defies a complete
understanding. In analogy to "all-versus-nothing" proofs of Bell nonlocality,
here we present a proof of steering without inequalities rendering the
detection of correlations leading to a violation of steering inequalities
unnecessary. We show that, given any two-qubit entangled state, the existence
of certain projective measurement by Alice so that Bob's normalized conditional
states can be regarded as two different pure states provides a criterion for
Alice-to-Bob steerability. A steering inequality equivalent to the
all-versus-nothing proof is also obtained. Our result clearly demonstrates that
there exist many quantum states which do not violate any previously known
steering inequality but are indeed steerable. Our method offers advantages over
the existing methods for experimentally testing steerability, and sheds new
light on the asymmetric steering problem.Comment: 7 pages, 2 figures. Accepted in Sci. Re
Flavour physics from an approximate U(2)^3 symmetry
The quark sector of the Standard Model exhibits an approximate U(2)^3 flavour
symmetry. This symmetry, broken in specific directions dictated by minimality,
can explain the success of the Cabibbo-Kobayashi-Maskawa picture of flavour
mixing and CP violation, confirmed by the data so far, while allowing for
observable deviations from it, as expected in most models of ElectroWeak
Symmetry Breaking. Building on previous work in the specific context of
supersymmetry, we analyze the expected effects and we quantify the current
bounds in a general Effective Field Theory framework. As a further relevant
example we then show how the U(2)^3 symmetry and its breaking can be
implemented in a generic composite Higgs model and we make a first analysis of
its peculiar consequences. We also discuss how some partial extension of U(2)^3
to the lepton sector can arise, both in general and in composite Higgs models.
An optimistic though conceivable interpretation of the considerations developed
in this paper gives reasons to think that new physics searches in the flavour
sector may be about to explore an interesting realm of phenomena.Comment: 29 pages, 5 figure
Psychosocial adversity and socioeconomic position during childhood and epigenetic age: analysis of two prospective cohort studies
Psychosocial adversity in childhood (e.g. abuse) and low socioeconomic position (SEP) can have significant lasting effects on social and health outcomes. DNA methylation-based biomarkers are highly correlated with chronological age; departures of methylation-predicted age from chronological age can be used to define a measure of age acceleration, which may represent a potential biological mechanism linking environmental exposures to later health outcomes. Using data from two cohorts of women Avon Longitudinal Study of Parents and Children, (ALSPAC), N = 989 and MRC National Survey of Health and Development, NSHD, N = 773), we assessed associations of SEP, psychosocial adversity in childhood (parental physical or mental illness or death, parental separation, parental absence, sub-optimal maternal bonding, sexual, emotional and physical abuse and neglect) and a cumulative score of these psychosocial adversity measures, with DNA methylation age acceleration in adulthood (measured in peripheral blood at mean chronological ages 29 and 47 in ALSPAC and buccal cells at age 53 in NSHD). Sexual abuse was strongly associated with age acceleration in ALSPAC (sexual abuse data were not available in NSHD), e.g. at the 47-year time point sexual abuse associated with a 3.41 years higher DNA methylation age (95% CI 1.53 to 5.29) after adjusting for childhood and adulthood SEP. No associations were observed between low SEP, any other psychosocial adversity measure or the cumulative psychosocial adversity score and age acceleration. DNA methylation age acceleration is associated with sexual abuse, suggesting a potential mechanism linking sexual abuse with adverse outcomes. Replication studies with larger sample sizes are warranted
Protecting an Ecosystem Service: Approaches to Understanding and Mitigating Threats to Wild Insect Pollinators
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