MOBILE PHONE APPLICATION DEVELOPMENT FOR INTERROGATING EXTERNAL SENSOR

Recently, Smartphone processing power shows a remarkable performance on doing multitask function set by the user. As the manufacturing industry has come to a further development on data inspection by such sensor for example; Temperature Sensor, Pressure Sensor, Level Sensor, etc, both task of acquiring and analyzing data will need to be carried out at different time. By utilizing mobile phone as the main target data acquisition, data are easily access at the end of the user finger tips. Literature review comprises all the keywords and terms that we need to know before we can proceed to the system development. The methodology focus on more on project flow, hardware and software used such as, Programmable Integrated Circuit (PIC) Microcontroller, Bluetooth Module, Lithium Polymer Battery, 02 XDA Mobile Phone, vxHpc Software, Windows Visual Studio 2008, MPLAB 8.10 and etc. As for the result, the external system already able to communicate and interconnect with mobile phone with the ability of vxHpc software to act as hyper terminal for mobile phone. The external device are attached with internal temperature sensor (LM35DZ) and able to be connected with 3 external sensors as the users are able to interrogate the whole system by giving command and getting specific sensor data from external sensor device. As for conclusion, the system can be already be used for specific application as the micro controller are already comprises eighty percent of its entire program memory utilization

MOBILE PHONE APPLICATION DEVELOPMENT FOR INTERROGATING EXTERNAL SENSOR

Recently, Smartphone processing power shows a remarkable performance on doing multitask function set by the user. As the manufacturing industry has come to a further development on data inspection by such sensor for example; Temperature Sensor, Pressure Sensor, Level Sensor, etc, both task of acquiring and analyzing data will need to be carried out at different time. By utilizing mobile phone as the main target data acquisition, data are easily access at the end of the user finger tips. Literature review comprises all the keywords and terms that we need to know before we can proceed to the system development. The methodology focus on more on project flow, hardware and software used such as, Programmable Integrated Circuit (PIC) Microcontroller, Bluetooth Module, Lithium Polymer Battery, 02 XDA Mobile Phone, vxHpc Software, Windows Visual Studio 2008, MPLAB 8.10 and etc. As for the result, the external system already able to communicate and interconnect with mobile phone with the ability of vxHpc software to act as hyper terminal for mobile phone. The external device are attached with internal temperature sensor (LM35DZ) and able to be connected with 3 external sensors as the users are able to interrogate the whole system by giving command and getting specific sensor data from external sensor device. As for conclusion, the system can be already be used for specific application as the micro controller are already comprises eighty percent of its entire program memory utilization

Effects of NCO/OH Ratios on Bio-Based Polyurethane Film Properties Made from Acacia mangium Liquefied Wood

The compatibility between isocyanate and polyol plays an important role in determining a polyurethane product’s performance. This study aims to evaluate the effect of varying the ratios between polymeric methylene diphenyl diisocyanate (pMDI) and Acacia mangium liquefied wood polyol on the polyurethane film properties. A. mangium wood sawdust was liquefied in polyethylene glycol/glycerol co-solvent with H₂SO₄ as a catalyst at 150 ◦C for 150 min. The A. mangium liquefied wood was mixed with pMDI with difference NCO/OH ratios to produce film through the casting method. The effects of the NCO/OH ratios on the molecular structure of the PU film were examined. The formation of urethane, which was located at 1730 cm⁻¹, was confirmed via FTIR spectroscopy. The TGA and DMA results indicated that high NCO/OH ratios increased the degradation temperature and glass transition from 275 ◦C to 286 ◦C and 50 ◦C to 84 ◦C, respectively. The prolonged heat appeared to boost the crosslinking density of the A. mangium polyurethane films, which finally resulted in a low sol fraction. From the 2D-COS analysis, the hydrogen-bonded carbonyl (1710 cm⁻¹) had the most significant intensity changes with the increasing NCO/OH ratios. The occurrence of the peak after 1730 cm⁻¹ revealed that there was substantial formation of urethane hydrogen bonding between the hard (PMDI) and soft (polyol) segments as the NCO/OH ratios increased, which gave higher rigidity to the film

Hysteresis-free perovskite transistor with exceptional stability through molecular cross-linking and amine-based surface passivation

This is the author accepted manuscript. The final version is available from the Royal Society of Chemistry via the DOI in this recordOrgano-metal halide perovskite field-effect transistors present serious challenges in terms of device stability and hysteresis in the current-voltage characteristics. Migration of ions located at grain boundaries and surface defects in the perovskite film are the main reasons for instability and hysteresis issues. Here, we introduce a perovskite grains molecular cross-linking approach combined with amine-based surface passivation to face these issues. Molecular cross-linking was achieved through hydrogen bond interactions between perovskite halogens and dangling bonds present at grain boundaries and a hydrophobic cross-linker, namely diethyl-(12-phosphonododecyl)phosphonate, added to the precursor solution. With our approach we obtained smooth and compact perovskite layers composed of few and tightly bound grains hence significantly suppressing the generation and migration of ions. Moreover, we obtained efficient surface passivation of the perovskite films upon surface treatment with an amine-bearing polymer, namely polyethylenimine ethoxylated. With our synergistic grain and surface passivation approach we were able to demonstrate the first perovskite transistor with complete lack of hysteresis and unprecedented stability upon continuous operation under ambient conditions. Added to the merits are its ambipolar transport of opposite carriers with balanced hole and electron mobilities of 4.02 and 3.35 cm2 V−1 s−1, respectively, its high Ion/Ioff ratio >104 and the lowest sub-thresshold swing of 267 mV dec-1 reported to date for any perovskite transistor. These remarkable achievements obtained through a cost-effective molecular cross-linking of grains combined with amine-based surface passivation in the perovskite films open new eras and pave the way for the practical application of perovskite transistors on low-cost electronic circuits.European Unio

Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK

Direct pharmacological targeting of the anti-apoptotic B-cell lymphoma-2 (BCL-2) family is an attractive therapeutic strategy for treating cancer. Obatoclax is a pan-BCL-2 family inhibitor currently in clinical development. Here we show that, although obatoclax can induce mitochondrial apoptosis dependent on BCL-2 associated x protein/BCL-2 antagonist killer (BAX/BAK) consistent with its on-target pharmacodynamics, simultaneous silencing of both BAX and BAK did not abolish acute toxicity or loss of clonogenicity. This is despite complete inhibition of apoptosis. Obatoclax dramatically reduced viability without inducing loss of plasma membrane integrity. This was associated with rapid processing of light chain-3 (LC3) and reduction of S6 kinase phosphorylation, consistent with autophagy. Dramatic ultrastructural vacuolation, not typical of autophagy, was also induced. Silencing of beclin-1 failed to prevent LC3 processing, whereas knockout of autophagy-related (Atg)7 abolished LC3 processing but failed to prevent obatoclax-induced loss of clonogenicity or ultrastructural changes. siRNA silencing of Atg7 in BAX/BAK knockout mouse embryonic fibroblasts did not prevent obatoclax-induced loss of viability. Cells selected for obatoclax resistance evaded apoptosis independent of changes in BCL-2 family expression and displayed reduced LC3 processing. In summary, obatoclax exhibits BAX- and BAK-dependent and -independent mechanisms of toxicity and activation of autophagy. Mechanisms other than autophagy and apoptosis are blocked in obatoclax resistant cells and contribute significantly to obatoclax's anticancer efficacy

Monitoring of Gene Expression in Bacteria during Infections Using an Adaptable Set of Bioluminescent, Fluorescent and Colorigenic Fusion Vectors

A family of versatile promoter-probe plasmids for gene expression analysis was developed based on a modular expression plasmid system (pZ). The vectors contain different replicons with exchangeable antibiotic cassettes to allow compatibility and expression analysis on a low-, midi- and high-copy number basis. Suicide vector variants also permit chromosomal integration of the reporter fusion and stable vector derivatives can be used for in vivo or in situ expression studies under non-selective conditions. Transcriptional and translational fusions to the reporter genes gfpmut3.1, amCyan, dsRed2, luxCDABE, phoA or lacZ can be constructed, and presence of identical multiple cloning sites in the vector system facilitates the interchange of promoters or reporter genes between the plasmids of the series. The promoter of the constitutively expressed gapA gene of Escherichia coli was included to obtain fluorescent and bioluminescent expression constructs. A combination of the plasmids allows simultaneous detection and gene expression analysis in individual bacteria, e.g. in bacterial communities or during mouse infections. To test our vector system, we analyzed and quantified expression of Yersinia pseudotuberculosis virulence genes under laboratory conditions, in association with cells and during the infection process

Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68); p<0.001), lower middle income (OR 3.32 (95% CI 1.96 to 5.61); p<0.001) and upper middle income (OR 3.49 (95% CI 2.02 to 6.03); p<0.001) country status and chemotherapy (OR 0.55 (95% CI 0.36 to 0.86); p=0.008) and immunotherapy (OR 0.27 (95% CI 0.08 to 0.91); p=0.035) within 30 days from MDT plan. Multivariable analysis revealed laboratory-confirmed SARS-CoV-2 infection (OR 5.33 (95% CI 1.19 to 23.84); p=0.029) was associated with 30-day mortality. Conclusions Children with cancer are more likely to die within 30 days if infected with SARS-CoV-2. However, timely treatment reduced odds of death. This report provides crucial information to balance the benefits of providing anticancer therapy against the risks of SARS-CoV-2 infection in children with cancer