Membrainy: a ‘smart’, unified membrane analysis tool

BACKGROUND: The study of biological membranes using Molecular Dynamics has become an increasingly popular means by which to investigate the interactions of proteins, peptides and potentials with lipid bilayers. These interactions often result in changes to the properties of the lipids which can modify the behaviour of the membrane. Membrainy is a unified membrane analysis tool that contains a broad spectrum of analytical techniques to enable: measurement of acyl chain order parameters; presentation of 2D surface and thickness maps; determination of lateral and axial headgroup orientations; measurement of bilayer and leaflet thickness; analysis of the annular shell surrounding membrane-embedded objects; quantification of gel percentage; time evolution of the transmembrane voltage; area per lipid calculations; and quantification of lipid mixing/demixing entropy. RESULTS: Each analytical component within Membrainy has been tested on a variety of lipid bilayer systems and was found to be either comparable to or an improvement upon existing software. For the analytical techniques that have no direct comparable software, our results were confirmed with experimental data. CONCLUSIONS: Membrainy is a user-friendly, intelligent membrane analysis tool that automatically interprets a variety of input formats and force fields, is compatible with both single and double bilayers, and capable of handling asymmetric bilayers and lipid flip-flopping. Membrainy has been designed for ease of use, requiring no installation or configuration and minimal user-input to operate

Role of project governance in managing projects sustainability: A theoretical perspective

Sustainability is incessantly posing challenges when it is studied juxtaposition with project management. To ensure sustainability companies undertaking projects ought to set strategic and operational plans that will add to the project sustainability. Research shows that existing project management structures do not effectively consider sustainability issues and therefore need revisions at strategic and operational levels. Similarly, while the theme of project governance is finding traction in the literature, the discussion that connects project governance and sustainability in projects is elusive. This research work is specifically focusing on developing a linkage between project governance and managing sustainability in projects. There is an acute scarcity of literature encircling linkage between project governance and sustainable project management, thus, based on the extensive review of the literature, this study is one of the pioneering studies to highlight the relationship between the themes of project governance and sustainable project management