Wilsonian dark matter in string derived Z' model

The dark matter issue is among the most perplexing in contemporary physics. The problem is more enigmatic due to the wide range of possible solutions, ranging from the ultra-light to the super-massive. String theory gives rise to plausible dark matter candidates due to the breaking of the non--Abelian Grand Unified Theory (GUT) symmetries by Wilson lines. The physical spectrum then contains states that do not satisfy the quantisation conditions of the unbroken GUT symmetry. Given that the Standard Model states are identified with broken GUT representations, and provided that any ensuing symmetry breaking is induced by components of GUT states, leaves a remnant discrete symmetry that forbid the decay of the Wilsonian states. A class of such states are obtained in a heterotic-string derived $Z^\prime$ model. The model exploits the spinor-vector duality symmetry, observed in the fermionic $Z_2\times Z_2$ heterotic-string orbifolds, to generate a $Z^\prime\in E_6$ symmetry that may remain unbroken down to low energies. The $E_6$ symmetry is broken at the string level with discrete Wilson lines. The Wilsonian dark matter candidates in the string derived model are $SO(10)$, and hence Standard Model, singlets and possess non-$E_6$ $U(1)_{Z^\prime}$ charges. Depending on the $U(1)_{Z^\prime}$ breaking scale and the reheating temperature they give rise to different scenarios for the relic abundance, and in accordance with the cosmological constraints.Comment: 24 pages. 5 figures. Standard LaTex. Additional comments and clarifications. Published versio

Wilsonian Dark Matter in String Derived Z′Z^\prime Model

The dark matter issue is among the most perplexing in contemporary physics. The problem is more enigmatic due to the wide range of possible solutions, ranging from the ultra-light to the super-massive. String theory gives rise to plausible dark matter candidates due to the breaking of the non--Abelian Grand Unified Theory (GUT) symmetries by Wilson lines. The physical spectrum then contains states that do not satisfy the quantisation conditions of the unbroken GUT symmetry. Given that the Standard Model states are identified with broken GUT representations, and provided that any ensuing symmetry breaking is induced by components of GUT states, leaves a remnant discrete symmetry that forbid the decay of the Wilsonian states. A class of such states are obtained in a heterotic-string derived $Z^\prime$ model. The model exploits the spinor-vector duality symmetry, observed in the fermionic $Z_2\times Z_2$ heterotic-string orbifolds, to generate a $Z^\prime\in E_6$ symmetry that may remain unbroken down to low energies. The $E_6$ symmetry is broken at the string level with discrete Wilson lines. The Wilsonian dark matter candidates in the string derived model are $SO(10)$, and hence Standard Model, singlets and possess non-$E_6$ $U(1)_{Z^\prime}$ charges. Depending on the $U(1)_{Z^\prime}$ breaking scale and the reheating temperature they give rise to different scenarios for the relic abundance, and in accordance with the cosmological constraints

Engaging Diverse Students in Statistical Inquiry: A Comparison of Learning Experiences and Outcomes of Under-Represented and Non-Underrepresented Students Enrolled in a Multidisciplinary Project-Based Statistics Course

Introductory statistics needs innovative, evidence-based teaching practices that support and engage diverse students. To evaluate the success of a multidisciplinary, project-based course, we compared experiences of under-represented (URM) and non-underrepresented students in 4 years of the course. While URM students considered the material more difficult than non-URM students, URM students demonstrated similar levels of increased confidence in applied skills and interest in follow up courses as non-URM students. URM students were found to be twice as likely as non-URM students to report that their interest in conducting research increased. Increasing student confidence and interest gives all students a welcoming place at the table that will afford the best hope for achieving the kind of statistical literacy necessary for interdisciplinary research

Office bladder distention with Electromotive Drug Administration (EMDA) is equivalent to distention under General Anesthesia (GA)

BACKGROUND: Bladder distention is commonly used in diagnosis and treatment of interstitial cystitis (IC). Traditionally performed in the operating room under general or spinal anesthesia (GA), it is expensive and associated with short term morbidity. Office bladder distention using electromotive drug administration (EMDA) has been suggested as an alternative that is well tolerated by patients. We report the first comparative findings of patients undergoing both office distention with EMDA and distention in the operating room (OR) with GA. METHODS: This retrospective chart review identified 11 patients participating in two protocols of EMDA bladder distention who also underwent bladder distention under GA either prior to or after the EMDA procedure. RESULTS: The median absolute difference in bladder capacity between GA and EMDA was only 25 cc; the median percent difference was 5%. Cystoscopic findings, while not prospectively compiled, appear to have been similar. CONCLUSION: This study represents the first comparison between distention with EMDA versus GA and confirms the technical feasibility of performing bladder distention in an office setting. The distention capacity achieved in the office was nearly identical to that in the OR and the cystoscopic findings very similar. Further investigation into the comparative morbidity, cost, and other outcome measures is warranted to define the ultimate role of EMDA bladder distention in the clinical evaluation and care of patients with IC

Evidence of global pollution and recent environmental change in Kamchatka, Russia

Kamchatka is a remote, isolated and understudied area and is presumed to be pristine. Here we present the first high-resolution palaeolimnological investigation of the recent past. A short core representing the last 250. years was taken from Olive-backed Lake situated in central Kamchatka. Lead-210 dating revealed that sediment accumulation has increased at the site since the 1960s and may be related to greater rates of catchment erosion associated with wetter winters in the region. Mercury and spheroidal carbonaceous particle (an unambiguous indicator of fossil fuel combustion) concentrations are low but clearly detectable indicating that both regional and global pollution sources are observed at this site. The recent increase in the flux of mercury is more related to catchment sources and catchment erosion than increases from regional or global sources. The diatom and chironomid populations are stable and do not show any statistically significant changes related to either the low levels of pollution, or to temperature and precipitation changes. The lake is not pristine since anthropogenic contamination has occurred but since there have been no significant effects on the flora and fauna the lake can be considered to be unimpacted. Olive-backed Lake may be a suitable reference site to benchmark the natural variability of a lake ecosystem

Safety, tolerability, and impact on allergic inflammation of autologous E.coli autovaccine in the treatment of house dust mite asthma - a prospective open clinical trial

Background: Asthma is increasing worldwide and results from a complex immunological interaction between genetic susceptibility and environmental factors. Autovaccination with E. coli induces a strong TH-1 immune response, thus offering an option for the treatment of allergic diseases. Methods: Prospective open trial on safety, tolerability, and impact on allergic inflammation of an autologous E.coli autovaccine in intermittent or mild persistent house dust mite asthma. Determination of exhaled nitric monoxide (eNO) before and after bronchial mite challenge initially and after nine months of autovaccination. Results: Median eNO increase after autovaccination was significantly smaller (from 27.3 to 33.8 ppb; p=0.334) compared to initial values (from 32.6 to 42.2 ppb; p=0.046) (p=0.034). In nine subjects and a total of 306 injections, we observed 101 episodes of local erythema (33.3%; median of maximal diameter 2.5 cm), 95 episodes of local swelling (31.1%; median of maximal diameter 3 cm), and 27 episodes of local pain (8.8%). Four subjects reported itching at the injection site with a total of 30 episodes (9.8%). We observed no serious adverse events. All organ functions (inclusive electrocardiogramm) and laboratory testing of the blood (clinical chemistry, hematology) and the urine (screening test, B-microglobuline) were within normal limits. Vital signs undulated within the physiological variability. Conclusion: The administration of autologous autovacine for the treatment of house dust mite asthma resulted in a reduction of the eNO increase upon bronchial mite challenge. In nine subjects and 306 injections, only a few mild local reactions and no systemic severe adverse events were observed. EudraCT Nr. 2005-005534-12 ClinicalTrials.gov ID NCT0067720

Mutational Biases and Selective Forces Shaping the Structure of Arabidopsis Genes

Recently features of gene expression profiles have been associated with structural parameters of gene sequences in organisms representing a diverse set of taxa. The emerging picture indicates that natural selection, mediated by gene expression profiles, has a significant role in determining genic structures. However the current situation is less clear in plants as the available data indicates that the effect of natural selection mediated by gene expression is very weak. Moreover, the direction of the patterns in plants appears to contradict those observed in animal genomes. In the present work we analized expression data for >18000 Arabidopsis genes retrieved from public datasets obtained with different technologies (MPSS and high density chip arrays) and compared them with gene parameters. Our results show that the impact of natural selection mediated by expression on genes sequences is significant and distinguishable from the effects of regional mutational biases. In addition, we provide evidence that the level and the breadth of gene expression are related in opposite ways to many structural parameters of gene sequences. Higher levels of expression abundance are associated with smaller transcripts, consistent with the need to reduce costs of both transcription and translation. Expression breadth, however, shows a contrasting pattern, i.e. longer genes have higher breadth of expression, possibly to ensure those structural features associated with gene plasticity. Based on these results, we propose that the specific balance between these two selective forces play a significant role in shaping the structure of Arabidopsis genes

Organisational participation and women - an attitude problem?

Employee participation is a dynamic and contested area of organisational behaviour, attracting continuing academic, practitioner and policy interest and debate. This chapter focuses on organisational participation and women