2,082 research outputs found
Flux Discharge Cascades in Various Dimensions
We study the dynamics of electric flux discharge by charged particle pair or
spherical string or membrane production in various dimensions. When electric
flux wraps at least one compact cycle, we find that a single "pair" production
event can initiate a cascading decay in real time that "shorts out" the flux
and discharges many units of it. This process arises from local dynamics in the
compact space, and so is invisible in the dimensionally-reduced truncation. It
occurs in theories as simple as the Schwinger model on a circle, and has
implications for any theory with compact dimensions and electric flux,
including string theories and the string landscape.Comment: 19+8 pages, 3 figures, 3 appendice
Local thermal adaptation and limited gene flow constrain future climate responses of a marine ecosystem engineer.
Rising ocean temperatures and extreme temperature events have precipitated declines and local extinctions in many marine species globally, but patterns of loss are often uneven across species ranges for reasons that are poorly understood. Knowledge of the extent of local adaptation and gene flow may explain such patterns and help predict future trajectories under scenarios of climate change. We test the extent to which local differentiation in thermal tolerance is influenced by gene flow and local adaptation using a widely distributed intertidal seaweed (Hormosira banksii) from temperate Australia. Population surveys across ~2,000 km of the species range revealed strong genetic structuring at regional and local scales (global F ST = 0.243) reflecting extremely limited gene flow, while common garden experiments (14-day exposures to 15, 18, 21°C) revealed strong site differences in early development and mortality in response to elevated temperature. Embryos from many sites spanning a longitudinal thermal gradient showed suppressed development and increased mortality to elevated water temperatures, but populations originating from warmer and more variable thermal environments tended to be less susceptible to warming. Notably, there was significant local-scale variation in the thermal responses of embryos within regions which was corroborated by the finding of small-scale genetic differences. We expect the observed genetic and phenotypic differentiation to lead to uneven responses to warming sea surface temperatures in this important marine foundation species. The study highlights the challenges of predicting species responses to thermal stress and the importance of management strategies that incorporate evolutionary potential for "climate-proofing" marine ecosystems
Probing Quantum Geometry at LHC
We present an evidence, that the volumes of compactified spaces as well as
the areas of black hole horizons must be quantized in Planck units. This
quantization has phenomenological consequences, most dramatic being for micro
black holes in the theories with TeV scale gravity that can be produced at LHC.
We predict that black holes come in form of a discrete tower with well defined
spacing. Instead of thermal evaporation, they decay through the sequence of
spontaneous particle emissions, with each transition reducing the horizon area
by strictly integer number of Planck units. Quantization of the horizons can be
a crucial missing link by which the notion of the minimal length in gravity
eliminates physical singularities. In case when the remnants of the black holes
with the minimal possible area and mass of order few TeV are stable, they might
be good candidates for the cold dark matter in the Universe.Comment: 14 pages, Late
On Inflation with Non-minimal Coupling
A simple realization of inflation consists of adding the following operators
to the Einstein-Hilbert action: (partial phi)^2, lambda phi^4, and xi phi^2 R,
with xi a large non-minimal coupling. Recently there has been much discussion
as to whether such theories make sense quantum mechanically and if the inflaton
phi can also be the Standard Model Higgs. In this note we answer these
questions. Firstly, for a single scalar phi, we show that the quantum field
theory is well behaved in the pure gravity and kinetic sectors, since the
quantum generated corrections are small. However, the theory likely breaks down
at ~ m_pl / xi due to scattering provided by the self-interacting potential
lambda phi^4. Secondly, we show that the theory changes for multiple scalars
phi with non-minimal coupling xi phi dot phi R, since this introduces
qualitatively new interactions which manifestly generate large quantum
corrections even in the gravity and kinetic sectors, spoiling the theory for
energies > m_pl / xi. Since the Higgs doublet of the Standard Model includes
the Higgs boson and 3 Goldstone bosons, it falls into the latter category and
therefore its validity is manifestly spoiled. We show that these conclusions
hold in both the Jordan and Einstein frames and describe an intuitive analogy
in the form of the pion Lagrangian. We also examine the recent claim that
curvature-squared inflation models fail quantum mechanically. Our work appears
to go beyond the recent discussions.Comment: 14 pages, 2 figures. Version 2: Clarified findings and improved
wording. Elaborated important sections and removed an unnecessary section.
Added references. Version 3: Updated towards JHEP version. Version 4: Final
JHEP versio
Global distribution of two fungal pathogens threatening endangered sea turtles
This work was supported by grants of Ministerio de Ciencia e Innovación, Spain (CGL2009-10032, CGL2012-32934). J.M.S.R was supported by PhD fellowship of the CSIC (JAEPre 0901804). The Natural Environment Research Council and the Biotechnology and Biological Sciences Research Council supported P.V.W. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Thanks Machalilla National Park in Ecuador, Pacuare Nature Reserve in Costa Rica, Foundations Natura 2000 in Cape Verde and Equilibrio Azul in Ecuador, Dr. Jesus Muñoz, Dr. Ian Bell, Dr. Juan Patiño for help and technical support during samplingPeer reviewedPublisher PD
A probabilistic unified approach for power indices in simple games
The final publication is available at Springer via https://doi.org/10.1007/978-3-662-60555-4_11Many power indices on simple games have been defined trying to measure, under different points of view, the “a priori” importance of a voter in a collective binary voting scenario. A unified probabilistic way to define some of these power indices is considered in this paper. We show that six well-known power indices are obtained under such a probabilistic approach. Moreover, some new power indices can naturally be obtained in this way.Peer ReviewedPostprint (author's final draft
The CMB and the measure of the multiverse
In the context of eternal inflation, cosmological predictions depend on the
choice of measure to regulate the diverging spacetime volume. The spectrum of
inflationary perturbations is no exception, as we demonstrate by comparing the
predictions of the fat geodesic and causal patch measures. To highlight the
effect of the measure---as opposed to any effects related to a possible
landscape of vacua---we take the cosmological model, including the model of
inflation, to be fixed. We also condition on the average CMB temperature
accompanying the measurement. Both measures predict a 1-point expectation value
for the gauge-invariant Newtonian potential, which takes the form of a
(scale-dependent) monopole, in addition to a related contribution to the
3-point correlation function, with the detailed form of these quantities
differing between the measures. However, for both measures both effects are
well within cosmic variance. Our results make clear the theoretical relevance
of the measure, and at the same time validate the standard inflationary
predictions in the context of eternal inflation.Comment: 28 pages; v2: reference added, some clarification
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Serum and CSF microRNAs in paediatric malignant GCTs
BACKGROUND: The current biomarkers alpha-fetoprotein and human chorionic gonadotropin have limited sensitivity and specificity for diagnosing malignant germ-cell tumours (GCTs). MicroRNAs (miRNAs) from the miR-371-373 and miR-302/367 clusters are overexpressed in all malignant GCTs, and some of these miRNAs show elevated serum levels at diagnosis. Here, we developed a robust technical pipeline to quantify these miRNAs in the serum and cerebrospinal fluid (CSF). The pipeline was used in samples from a cohort of exclusively paediatric patients with gonadal and extragonadal malignant GCTs, compared with appropriate tumour and non-tumour control groups. METHODS: We developed a method for miRNA quantification that enabled sample adequacy assessment and reliable data normalisation. We performed qRT-PCR profiling for miR-371-373 and miR-302/367 cluster miRNAs in a total of 45 serum and CSF samples, obtained from 25 paediatric patients. RESULTS: The exogenous non-human spike-in cel-miR-39-3p and the endogenous housekeeper miR-30b-5p were optimal for obtaining robust serum and CSF qRT-PCR quantification. A four-serum miRNA panel (miR-371a-3p, miR-372-3p, miR-373-3p and miR-367-3p): (i) showed high sensitivity/specificity for diagnosing paediatric extracranial malignant GCT; (ii) allowed early detection of relapse of a testicular mixed malignant GCT; and (iii) distinguished intracranial malignant GCT from intracranial non-GCT tumours at diagnosis, using CSF and serum samples. CONCLUSIONS: The pipeline we have developed is robust, scalable and transferable. It potentially promises to improve clinical management of paediatric (and adult) malignant GCTs.Grant funding was from CwCUK/GOSHCC (M.J. Murray, K.L. Raby, J.C. Nicholson, N. Coleman), SPARKS (M.J. Murray, J.C. Nicholson, N. Coleman), AstraZeneca (E. Bell, H. Brown and B. Destenaves), CRUK (N. Coleman), MRC (M.J. Murray) and an Erasmus MC MRACE grant (M.A. Rijlaarsdam). The authors also thank the Max Williamson Fund and The Perse Preparatory School, Cambridge for supporting this study.This is the author accepted manuscript. The final version is available from NPG via http://dx.doi.org/10.1038/bjc.2015.42
Composite Leptoquarks at the LHC
If electroweak symmetry breaking arises via strongly-coupled physics, the
observed suppression of flavour-changing processes suggests that fermion masses
should arise via mixing of elementary fermions with composite fermions of the
strong sector. The strong sector then carries colour charge, and may contain
composite leptoquark states, arising either as TeV scale resonances, or even as
light, pseudo-Nambu-Goldstone bosons. The latter, since they are coupled to
colour, get a mass of the order of several hundred GeV, beyond the reach of
current searches at the Tevatron. The same generic mechanism that suppresses
flavour-changing processes suppresses leptoquark-mediated rare processes,
making it conceivable that the many stringent constraints may be evaded. The
leptoquarks couple predominantly to third-generation quarks and leptons, and
the prospects for discovery at LHC appear to be good. As an illustration, a
model based on the Pati-Salam symmetry is described, and its embedding in
models with a larger symmetry incorporating unification of gauge couplings,
which provide additional motivation for leptoquark states at or below the TeV
scale, is discussed.Comment: 10 pp, version to appear in JHE
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