Long transients and cluster size in globally coupled maps

We analyze the asymptotic states in the partially ordered phase of a system of globally coupled logistic maps. We confirm that, regardless of initial conditions, these states consist of a few clusters, and they properly belong in the ordered phase of these systems. The transient times necessary to reach the asymptotic states can be very long, especially very near the transition line separating the ordered and the coherent phases. We find that, where two clusters form, the distribution of their sizes corresponds to windows of regular or narrow-band chaotic behavior in the bifurcation diagram of a system of two degrees of freedom that describes the motion of two clusters, where the size of one cluster acts as a bifurcation parameter.Comment: To appear in Europhysics Letter

How Managed Behavioral Health Care Impacts Psychotherapeutic Practices

The cost of health and mental health care is a growing problem for the United States. Managed care evolved as a way to continue providing quality services in a cost-effective fashion. In the mental health field, some individuals believe managed care reduces the quality of treatment. This exploratory study investigates current sentiments among mental health clinicians regarding managed care’s impact on mental health treatment and looks at how clinicians practice in light of managed care’s guidelines for treating patients. This study explores the current impact of managed care compared with managed care’s first detectable impact in the 1980s

F0, EMG and Tonogensis in Thai

This paper, based on examination of initial F0 of bilabial stops in Standard Thai, reports that pre-voiced bilabial stops (negative VOT) have lower initial F0 than the voiceless (approximately 0ms VOT) or voiceless aspirated stops (those with positive VOT). Also reported in this paper are measurements from electromyographic (EMG) laryngeal muscle activity (cricothyroid and strap muscles) associated with the initial F0 of the bilabial stops. The F0 and EMG data are discussed in terms of historical theories of tonogenesis for Thai. The F0 data support the hypothesis of tonogenesis as put forth by historical linguists; however, a connection between the laryngeal muscles examined and the high/low intrinsic F0 of the bilabial stops was not found. Additional acoustic, aerodynamic and laryngeal research is needed in order to understand the interaction between initial stops and the development of tones

Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling.

The tumor microenvironment (TME) exerts critical pro-tumorigenic effects through cytokines and growth factors that support cancer cell proliferation, survival, motility and invasion. Insulin-like growth factor-1 (IGF-1) and signal transducer and activator of transcription 3 (STAT3) stimulate colorectal cancer development and progression via cell autonomous and microenvironmental effects. Using a unique inhibitor, NT157, which targets both IGF-1 receptor (IGF-1R) and STAT3, we show that these pathways regulate many TME functions associated with sporadic colonic tumorigenesis in CPC-APC mice, in which cancer development is driven by loss of the Apc tumor suppressor gene. NT157 causes a substantial reduction in tumor burden by affecting cancer cells, cancer-associated fibroblasts (CAF) and myeloid cells. Decreased cancer cell proliferation and increased apoptosis were accompanied by inhibition of CAF activation and decreased inflammation. Furthermore, NT157 inhibited expression of pro-tumorigenic cytokines, chemokines and growth factors, including IL-6, IL-11 and IL-23 as well as CCL2, CCL5, CXCL7, CXCL5, ICAM1 and TGFβ; decreased cancer cell migratory activity and reduced their proliferation in the liver. NT157 represents a new class of anti-cancer drugs that affect both the malignant cell and its supportive microenvironment

ELECTROKINETIC PHENOMENA : XIII. A COMPARISON OF THE ISOELECTRIC POINTS OF DISSOLVED AND CRYSTALLINE AMINO ACIDS

1. Although the isoelectric points of dissolved cystine, tyrosine, and aspartic acid molecules lie at widely differing pH values, the isoelectric points of the surfaces of these substances in the crystalline state are all near pH 2.3. This was found to be true in solutions of hydrochloric acid and in acetate buffers of approximately constant ionic strength. 2. When suspended in gelatin, tyrosine and cystine crystals adsorb the protein and attain a surface identical in behavior with gelatin-coated quartz or collodion particles. 3. Aluminum ions at low concentrations reduce the electric mobilities of tyrosine crystals to zero in a manner analogous to their effect on other surfaces. 4. Alkyl benzene droplets also have their electric mobility reduced to zero at low pH values but, unlike the amino acids, a change in sign was never noticed. 5. The mobility of tyrosine crystals is independent of crystal length between 2–100µ. Below this size the mobilities are decreased. 6. These results are discussed in connection with the concept of the general definition of the isoelectric point and the behavior of certain insoluble proteins such as wool and silk fibroin

THE ELECTRICAL CHARGE OF MAMMALIAN RED BLOOD CELLS

In Vol. 19, No. 4, March 20, 1936, page 603, in the eleventh line from the bottom of the page for "zj = 2, zjj = 1", read "zj = 1, zjj = 2". On the same page in the fourteenth line from the bottom of the page for "jj(HPO4-)" read "jj(HPO4--)"