Hesperidin effects on behavior and locomotor activity of diabetic Wistar rat

Today, there are sufficient validated scientific data that support the existence of relations between diabetes and certain neuropsychiatric disorders, such as behavioral disorders, anxiety, cognitive decline and depression. The objective of this work was to investigate the effect of a natural bioflavonoid, the antioxidant hesperidin on the neuro behavioral alterations and locomotor function in streptozotocine diabetic wistar rats. Twenty eight male rats were divided equally into four groups; control, and treated series (hesperidin, streptozotocine and hesperidin+ streptozotocine) then exposed to open field test, where animals were individually placed in the center of the compartment for a period of 5 min. Results of the open field test showed high level of anxiety and a slowdown in locomotion and mental flexibility on diabetic rats. Treatment with hesperidin, significantly module these disorders of the animals related to diabetes. Thus, our results confirm the capacity of hesperidin as an antioxidant, to correct neurobehavioral and locomotion disorders related to diabetes and its complications by neutralizing free radicals generated by this metabolic disease.Key words: Diabetes, oxidative stress, hesperidin, streptozotocine

Recent warming trends inferred from borehole temperature data in Figuig area (Eastern Morocco)

Ground surface temperature history (GSTH) reflecting the past climate conditions in eastern Morocco was evaluated by analyzing the temperature–depth profiles measured in four boreholes at the Figuig Oasis. The temperature–depth data were inverted using the functional space inversion method in order to reconstruct the surface temperature past changes. The results reveal a recent warming in the last century with an amplitude of 1–3 C for the four boreholes and a comparison with surface air temperature (SAT) variation from the Bouarfa and Bechar meteorological stations confirms this result. This warming trend is confirmed by other climate proxies

Pond Energy Dynamics, Evaporation Rate and Ensemble Deep Learning Evaporation Prediction: Case Study of the Thomas Pond—Brenne Natural Regional Park (France)

The energy of water masses is a first-order factor that controls the essential physicochemical dynamics of a water body. Its study allows one to understand the roots of the processes that occur at the water-mass, water-atmosphere and water-sediment interfaces. The analysis of the Thomas Pond in the Brenne region gives a valuable overview of energy stock evolution on a yearly scale. It highlights the direct impact of this evolution on thermal stratification and the potential for evaporation and exchange with the atmosphere. The study of evaporation remains challenging due to the complexity of the energy processes and factors involved. Its estimation using formulas, which are mostly empirical, is one of the most used means for studying the process. The studied pond shows a natural stratification during the summer season, however often fragile and disturbed by other climatic factors such as wind and precipitation. This disruption leads to increased exchanges between the pond and the atmosphere. The methods used to estimate pond-atmosphere exchanges, namely evaporation, vary in values ranging between 1 mm/d to &gt; 15 mm/d. Among these methods, three stand out and seem to give reasonable values. This observation is based on the noticeable drop of the pond’s water level during the period of non-communication with the outside, which corresponds to 65 mm. The energy required for this evaporation varies between 600 W/m2 and 1500 W/m2, except for the Smith model, that slightly overestimates this parameter. The regulation of ponds’ water volumes by managers, the increased duration of bungs closure and the intermittence of precipitations in recent years exacerbate the reduction of direct inputs to ponds and the aggravates the impacts of a changing climate. Under the effect of increasing air temperatures, losses by evaporation will also increase significantly. If we generalise the results obtained to all of the Brenne Park water bodies (4500 ponds of the park), losses by evaporation will lead to a significant water deficit of the Loire basin. From this study, the use of deep learning ensemble models was found to provide better short-term predictions (RMSE between 0.003 and 0.006 for all methods), thus confirming the effectiveness of these methods for similar applications.</jats:p

Contribution to the inventory of lichens encountered in the reserve of Sidi Boughaba (Morocco)

ABSTRACT A study of the lichen flora encountered in the Sid

Wound healing and analgesic effects of Brocchia cinerea essential oil in experimental animals

This study aimed to identify the main components of the essential oil extracted from Brocchia cinerea (Delile) Vis. via hydrodistillation and investigate its in vivo wound healing and analgesic properties. Thujone, santolina triene, camphor, and 1,8-cineole were among the compounds detected. Wounds were induced in mice and treated with essential oil, which resulted in accelerated wound healing and repair through topical application (88.1±1.1%). The study also evaluated the analgesic activity of the essential oil by administering intraperitoneal injections of acetic acid to mice. The results showed that B. cinerea essential oil at a dose of 400 mg/kg strongly inhibited pain, with a pain inhibition percentage of 95.5%. These findings indicate that the essential oil of B. cinerea has potential as a source of bioactive compounds that may have synergistic effects. Based on these results, the use of B. cinerea for therapeutic purposes in preventing pain and promoting wound healing is supported. These findings highlight the potential of B. cinerea in paving the way for future research aimed at the development of clinically valuable products

Brocchia cinerea (Delile) Vis. Essential Oil Antimicrobial Activity and Crop Protection against Cowpea Weevil Callosobruchus maculatus (Fab.)

Antibiotics and synthetic pesticides are now playing a role in the spread of resistant pathogens. They continue to have negative consequences for animal and plant health. The goal of this work is to identify the chemical composition of Brocchia cinerea (Delile) Vis. essential oil (EO) using GC-MS(Gas Chromatography-Mass Spectrometer), evaluate its antimicrobial properties, and investigate its insecticidal and repellent effectiveness against Callosobruchus maculatus (C. maculatus). The GC-MS indicated the presence of 21 chemicals, with thujone (24.9%), lyratyl acetate (24.32%), camphor (13.55%), and 1,8-cineole (10.81%) being the most prominent. For the antimicrobial assay, the yeast Candida albicans was very sensitive to the EO with a growth inhibition diameter of (42.33 mm), followed by Staphylococcus aureus (31.33 mm). Fusarium oxysporum is the mycelia strain that appeared to be extremely sensitive to the utilized EO (88.44%) compared to the two species of Aspergillus (A. flavus (48.44%); A. niger (36.55%)). The results obtained in the microdilution method show that Pseudomonas aeruginosa was very sensitive to the EO, inhibited by a very low dose (0.0018 mg/mL). The minimum inhibitory concentration (MIC) results were between 0.0149 and 0.06 mg/mL. B. cinerea EO also demonstrated a potent insecticidal effect and a medium repulsive effect against C. maculatus. Thus, the LC50 value in the contact test was 0.61 μL/L of air, lower than that observed in the inhalation test (0.72 μL/L of air). The present study reveals that B. cinerea EO has the potential to be an antimicrobial and insecticidal agent with a better performance against several pathogenic microorganisms

Brocchia cinerea (Delile) Vis. Essential Oil Antimicrobial Activity and Crop Protection against Cowpea Weevil Callosobruchus maculatus (Fab.)

Antibiotics and synthetic pesticides are now playing a role in the spread of resistant pathogens. They continue to have negative consequences for animal and plant health. The goal of this work is to identify the chemical composition of Brocchia cinerea (Delile) Vis. essential oil (EO) using GC-MS(Gas Chromatography-Mass Spectrometer), evaluate its antimicrobial properties, and investigate its insecticidal and repellent effectiveness against Callosobruchus maculatus (C. maculatus). The GC-MS indicated the presence of 21 chemicals, with thujone (24.9%), lyratyl acetate (24.32%), camphor (13.55%), and 1,8-cineole (10.81%) being the most prominent. For the antimicrobial assay, the yeast Candida albicans was very sensitive to the EO with a growth inhibition diameter of (42.33 mm), followed by Staphylococcus aureus (31.33 mm). Fusarium oxysporum is the mycelia strain that appeared to be extremely sensitive to the utilized EO (88.44%) compared to the two species of Aspergillus (A. flavus (48.44%); A. niger (36.55%)). The results obtained in the microdilution method show that Pseudomonas aeruginosa was very sensitive to the EO, inhibited by a very low dose (0.0018 mg/mL). The minimum inhibitory concentration (MIC) results were between 0.0149 and 0.06 mg/mL. B. cinerea EO also demonstrated a potent insecticidal effect and a medium repulsive effect against C. maculatus. Thus, the LC50 value in the contact test was 0.61 μL/L of air, lower than that observed in the inhalation test (0.72 μL/L of air). The present study reveals that B. cinerea EO has the potential to be an antimicrobial and insecticidal agent with a better performance against several pathogenic microorganisms