Photoelectric response of Schottky barrier in La0.7 Ca0.3 Mn O3 Nb:SrTi O3 heterojunctions

Heterojunctions composed of La0.7 Ca0.3 Mn O3 and 0.05 wt % Nb-doped SrTi O3 were fabricated using pulse laser deposition. The current-voltage characteristics of such heterojunctions can be described by tunneling with an effective Schottky barrier. These junctions showed significant response to ultraviolet and visible light. Band-to-band and internal photoemission were characterized by photoelectric experiments. A quantum efficiency of about 86% was observed at an incident energy of ∼3.95 eV, which corresponds to the band-to-band excitation of electrons in Nb:SrTi O3. From the internal photoemission, the height of Schottky barrier was determined as 1.64 eV. © 2008 American Institute of Physics.published_or_final_versio

Comprehensive and Holistic Analysis of HT-29 Colorectal Cancer Cells and Tumor-Bearing Nude Mouse Model: Interactions Among Fractions Derived From the Chinese Medicine Formula Tian Xian Liquid in Effects on Human Colorectal Carcinoma

The Chinese medicine formula Tian Xian Liquid (TXL) has been used clinically for cancer therapy in China for more than 25 years. However, the comprehensive and holistic effects of its bioactive fractions for various antitumor therapeutic effects have not been unraveled. This is the first study to scientifically elucidate the holistic effect of Chinese medicine formula for treating colon cancer, hence allowing a better understanding of the essence of Chinese medicine formula, through the comparison of the actions of TXL and its functional constituent fractions, including ethyl acetate (EA), butanol (BU), and aqueous (WA) fractions. Tissue-specific proliferative/antiproliferative effects of these fractions on human colorectal carcinoma HT-29 cells and splenocytes were studied by using the MTT assay. Their modulations on the expression of markers of antiproliferation, antimetastasis, reversion of multidrug resistance in treated HT-29 cells were examined with real-time polymerase chain reaction and Western blot analysis, and their modulations in a xenografted nude mouse model were examined by Western blot analysis. Results revealed that EA fraction slightly inhibited the proliferation of HT-29 cells, but tissue-specifically exerted the most potent antiproliferative effect on splenocytes. On the contrary, only TXL and BU fraction tissue-specifically contributed to the proliferation of splenocytes, but inhibited the proliferation of HT-29 cells. WA fraction exerted the most potent antiproliferative effect on HT-29 cells and also the strongest inhibitory action on tumor size in the nude mouse model in our previous study. In the HT-29 model, TXL and WA fraction exerted the most pronounced effect on upregulation of p21 mRNA and protein; TXL, and EA and WA fractions exerted the effect on downregulation of G1 phase cell cycle protein, cyclin D1 mRNA and protein; EA and BU fractions exerted the most prominent anti-invasive effect on anti-invasion via downregulation of MMP-1 mRNA; TXL potently reversed most multidrug resistance via downregulation of MDR-1 protein. In conclusion, the comprehensive and holistic effects of TXL were demonstrated with (a) mutual accentuation and mutual enhancement, (b) mutual counteraction and mutual suppression, and (c) mutual antagonism among the 3 constituent fractions. Moreover, the design of the present study may lead to further development of more tissue-specific effective drugs with minimal side effects for clinical use in combating carcinoma.published_or_final_versio

Design of a pulse power supply unit for micro-ECM

Electrochemical micro-machining (μECM) requires a particular pulse power supply unit (PSU) to be developed in order to achieve desired machining performance. This paper summarises the development of a pulse PSU meeting the requirements of μECM. The pulse power supply provides tens of nanosecond pulse duration, positive and negative bias voltages and a polarity switching functionality. It fulfils the needs for tool preparation with reversed pulsed ECM on the machine. Moreover, the PSU is equipped with an ultrafast overcurrent protection which prevents the tool electrode from being damaged in case of short circuits. The developed pulse PSU was used to fabricate micro-tools out of 170 μm WC-Co alloy shafts via micro-electrochemical turning and drill deep holes via μECM in a disk made of 18NiCr6. The electrolyte used for both processes was a mixture of sulphuric acid and NaNO3 aqueous solutions.The research reported in this paper is supported by the European Commission within the project “Minimizing Defects in Micro-Manufacturing Applications (MIDEMMA)” (FP7-2011-NMP-ICT-FoF-285614

Design of an electrochemical micromachining machine

Electrochemical micromachining (μECM) is a non-conventional machining process based on the phenomenon of electrolysis. μECM became an attractive area of research due to the fact that this process does not create any defective layer after machining and that there is a growing demand for better surface integrity on different micro applications including microfluidics systems, stress-free drilled holes in automotive and aerospace manufacturing with complex shapes, etc. This work presents the design of a next generation μECM machine for the automotive, aerospace, medical and metrology sectors. It has three axes of motion (X, Y, Z) and a spindle allowing the tool-electrode to rotate during machining. The linear slides for each axis use air bearings with linear DC brushless motors and 2-nm resolution encoders for ultra precise motion. The control system is based on the Power PMAC motion controller from Delta Tau. The electrolyte tank is located at the rear of the machine and allows the electrolyte to be changed quickly. This machine features two process control algorithms: fuzzy logic control and adaptive feed rate. A self-developed pulse generator has been mounted and interfaced with the machine and a wire ECM grinding device has been added. The pulse generator has the possibility to reverse the pulse polarity for on-line tool fabrication.The research reported in this paper is supported by the European Commission within the project “Minimizing Defects in Micro-Manufacturing Applications (MIDEMMA)” (FP7-2011-NMPICT- FoF-285614)

NBTI-Generated Defects in Nanoscaled Devices: Fast Characterization Methodology and Modeling

Negative bias temperature instability (NBTI)-generated defects (GDs) have been widely observed and known to play an important role in device’s lifetime. However, its characterization and modeling in nanoscaled devices is a challenge due to their stochastic nature. The objective of this paper is to develop a fast and accurate technique for characterizing the statistical properties of NBTI aging, which can be completed in one day and thus reduce test time significantly. The fast speed comes from replacing the conventional constant voltage stress by the voltage step stress (VSS), while the accuracy comes from capturing the GDs without recovery. The key advances are twofold: first, we demonstrate that this VSS-GD technique is applicable for nanoscaled devices; second, we verify the 15 accuracy of the statistical model based on the parameters extracted from this technique against independently measured data. The proposed method provides an effective solution for GD evaluation, as required when qualifying a CMOS process

Performance and simulated moment uncertainties of an ion spectrometer with asymmetric 2π field of view for ion measurements in space

Space plasma instruments provide 3D particle velocity distribution functions. Because of telemetry limitations, these cannot be transmitted in high time resolution and the plasma needs to be characterized by moments of the velocity distribution function. These moment uncertainties have vital effects on the reliability and accuracy of onboard plasma moments. We assess the measurement accuracy for magnetosheath and solar wind ions using an ion spectrometer with an asymmetric field of view designed for the all-sky measurement of low-energy ions in the magnetosheath and solar wind. We focus on moment uncertainties for the ideal spectrometer, not considering the background counts, which may have considerable effects on the uncertainties in real life. To obtain number density, bulk velocity, and temperature, different orders of moments are integrated assuming a Maxwellian velocity distribution. Based on the design specifications, we use simulations to estimate systematic and random errors for typical plasma conditions. We find that the spectrometer resolution is adequate for determining the density of solar wind (∼7% error) and magnetosheath ions (∼4% error). The resolution is also adequate for determining the temperature of solar wind (∼10% error) and magnetosheath ions (∼2% error). For high speed flows with a bulk velocity of 750 km/s and a temperature of 20 eV, the maximum density and temperature errors become 9% and 7%, respectively. The bulk velocity errors are less than 2% for all cases. The contributions of heavy ions to the systematic errors are less than 5% for magnetosheath ions and less than 8% for solar wind ions

Establishing an appeal mechanism for investor-state dispute settlement : challenges, feasibility, and options

There is a growing international consensus stating investor-state dispute settlement mechanism (ISDS), with international investment arbitration as the main means of dispute settlement, needs to be reformed, but the reform proposals have not yet been finalised. Among the many options, the option of establishing an appeal mechanism has generated extensive discussion. The permanent, independent and corrective nature of the appeals mechanism helps to address the lack of independence and impartiality of arbitrators under the ISDS mechanism, the inconsistency of arbitral awards, and the lack of control mechanisms. It also has benefit of improving the accuracy of awards. Under the current system of international investment treaties, establishing a multilateral appeal mechanism presents many challenges. However, the Mauritius Convention on Transparency, which uses multilateral instruments to amend bilateral treaties, provides evidence that establishing a multilateral appeal mechanism is feasible

Impact of Hot Carrier Aging on Random Telegraph Noise and Within a Device Fluctuation

For nanometer MOSFETs, charging and discharging a single trap induces random telegraph noise (RTN). When there are more than a few traps, RTN signal becomes complex and appears as within a device fluctuation (WDF). RTN/WDF causes jitters in switch timing and is a major challenge to low power circuits. In addition to RTN/WDF, devices also age. The interaction between RTN/WDF and aging is of importance and not fully understood. Some researchers reported aging increasing RTN/WDF, while others showed RTN/WDF being hardly affected by aging. The objective of this work is to investigate the impact of hot carrier aging (HCA) on the RTN/WDF of nMOSFETs. For devices of average RTN/WDF, it is found that the effect of HCA is generally modest. For devices of abnormally high RTN/WDF, however, for the first time, we report HCA reducing RTN/WDF substantially (>50%). This reduction originates from either a change of current distribution or defect losses

Impact of Hot Carrier Aging on Random Telegraph Noise and Within a Device Fluctuation

For nanometer MOSFETs, charging and discharging a single trap induces random telegraph noise (RTN). When there are more than a few traps, RTN signal becomes complex and appears as within a device fluctuation (WDF). RTN/WDF causes jitters in switch timing and is a major challenge to low power circuits. In addition to RTN/WDF, devices also age. The interaction between RTN/WDF and aging is of importance and not fully understood. Some researchers reported aging increasing RTN/WDF, while others showed RTN/WDF being hardly affected by aging. The objective of this work is to investigate the impact of hot carrier aging (HCA) on the RTN/WDF of nMOSFETs. For devices of average RTN/WDF, it is found that the effect of HCA is generally modest. For devices of abnormally high RTN/WDF, however, for the first time, we report HCA reducing RTN/WDF substantially (>50%). This reduction originates from either a change of current distribution or defect losses