15 research outputs found
USAGE OF AC PLASMA TORCH FOR PRODUCTION OF OXIDE POWDERS
The report deals with the synthesis of oxide materials in a plasma torch with separate injection of plasma-forming gas and solid aerosol of precursors. Thus, it is possible to provide a stability of the plasma torch operation and high degree of mixing of thermal plasma and precursors.188-18
THERMAL STEAM PLASMA DECOMPOSITION OF ORGANOCHLORINE COMPOUNDS
The report considers the decomposition of carbon tetrachloride and chlorobenzene by the plasma obtained in an AC plasma torch with separate supply of shielding gas and reaction components.171-17
HIGH VOLTAGE AC PLASMA TORCH OPERATING ON VAPORS OF ORGANIC SUBSTANCES
The report deals with a three-phase high-voltage plasma torch with separate supply of gases and vapors during its operation on a mixture of steam, carbon dioxide, methane and chlorobenzene vapors. Increase in the chlorobenzene flow rate leads to increase in the arc voltage drop and electric power from 100 to 140 kW.99-9
Clinical experience with cyclosporine eye drops for severe dry eye
O.I. Lebedev1, A.V. Surov1, E.V. Akentieva2
1Omsk State Medical University, Omsk, Russian Federation
2Clinical Ophthalmologic Hospital named after V.P. Vykhodtsev, Omsk, Russian Federation
Dry eye disease provokes inflammation of autoimmune origin. Therefore, immunosuppressants are pathogenetically reasonable for this disorder. Topical 0.05% cyclosporine emulsion may provide good treatment outcomes when tear replacement drops and corneal protective remedies are ineffective. Cyclosporine is a calcineurin inhibitor which blocks T cells thus decreasing pro-inflammatory cytokine release and preventing goblet cell apoptosis. This paper describes clinical experience with cyclosporine in a woman with severe dry eye who received long-term treatment without stable favorable outcomes. Topical 0.05% cyclosporine emulsion (eye drops) improves subjective signs and functional test results as well as provides corneal infiltrate epithelialization. The analysis of clinical sings and functional test results demonstrates that cyclosporine is highly effective for severe dry eye which manifests with corneal and conjunctival inflammation and degeneration (especially considering autoimmune origin of the inflammation). In addition, this agent provides favorable outcomes when standard tear replacement and anti-inflammatory treatment is ineffective.
Key words: dry eye, xerosis, autoimmune inflammation, apoptosis, goblet cells, anti-inflammatory treatment, cyclosporine.
For citation: Lebedev O.I., Surov A.V., Akentieva E.V. Clinical experience with cyclosporine eye drops for severe dry eye. Russian Journal of Clinical Ophthalmology. 2019;19(1):50β53.
About the authors:
1Πleg I. Lebedev β MD, PhD, Professor, Head of Ophthalmological Department;
1Aleksandr V. Surov β MD, PhD, Associate Professor of Ophthalmological Department;
2Yevgeniya V. Akentyeva β ophthalmologist.
1Omsk State Medical University. 12, Lenin str., Πmsk, 644099, Russian Federation.
2Clinical Ophthalmologic Hospital named after V.P. Vykhodtsev. 60, Lermontov str., Πmsk, 644024, Russian Federation.
Contact information: Aleksandr V. Surov, e-mail: [email protected]. Financial Disclosure: no author has a financial or property interest in any material or method mentioned. There is no conflict of interests. Received: 18.09.2018.<br
Molecular phylogenetics and taxonomy of dwarf hamsters Cricetulus Milne-Edwards, 1867 (Cricetidae, Rodentia): description of a new genus and reinstatement of another
Lebedev, V.S., Bannikova, A.A., Neumann, K., Ushakova, M.V., Ivanova, N.V., Surov, A.V. (2018): Molecular phylogenetics and taxonomy of dwarf hamsters Cricetulus Milne-Edwards, 1867 (Cricetidae, Rodentia): description of a new genus and reinstatement of another. Zootaxa 4387 (2): 331-349, DOI: https://doi.org/10.11646/zootaxa.4387.2.
THERMAL STEAM PLASMA DECOMPOSITION OF ORGANOCHLORINE COMPOUNDS
171-171The report considers the decomposition of carbon tetrachloride and chlorobenzene by the plasma obtained in an AC plasma torch with separate supply of shielding gas and reaction components
USAGE OF AC PLASMA TORCH FOR PRODUCTION OF OXIDE POWDERS
188-188The report deals with the synthesis of oxide materials in a plasma torch with separate injection of plasma-forming gas and solid aerosol of precursors. Thus, it is possible to provide a stability of the plasma torch operation and high degree of mixing of thermal plasma and precursors
Π‘ΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΎΠ΄Π½ΠΎΡΡΠ°ΠΏΠ½ΠΎΠΉ ΠΈ Π΄Π²ΡΡ ΡΡΠ°ΠΏΠ½ΠΎΠΉ ΡΡΠ΅ΡΡΠΎΠΏΠ»Π°ΡΡΠΈΠΊΠΈ ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΏΡΠΎΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΡΠΌΠΈ ΡΠΎΡΠΌΠ°ΠΌΠΈ Π³ΠΈΠΏΠΎΡΠΏΠ°Π΄ΠΈΠΈ. ΠΠΎΡΠΊΡΡ ΠΈΠ»ΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°Ρ?
BACKGROUND: Surgical treatment of proximal forms of hypospadias in children is still a complex and largely unsolved problem. The large number of postoperative complications following reconstructive surgery for proximal forms of hypospadias supports scientific interest in this issue.
AIM: This study aimed to conduct a retrospective comparative analysis of the effectiveness of two types of urethroplasty. We compared fundamentally different approaches to the formation of the artificial urethra, surgical techniques that use a different type of movement, and blood supply of the plastic materials a flap and a graft.
MATERIALS AND METHODS: The study included 113 primary patients with proximal hypospadias aged 8 months to 15 years who underwent surgery between 2013 and 2019 and were divided into two comparison groups. Group 1 included 53 (46.9%) boys; a single-stage urethroplasty was performed by the onlay-tube method, where a longitudinal skin flap of the dorsal surface of the penis was used as a plastic material. Group 2 included 60 (53.1%) patients; two-stage urethroplasty was performed by the Bracka method, where the plastic material for the formation of the artificial urethra was a preputial graft in 44 (73.3%) patients and a graft of the oral mucosa in 16 (26.7%) patients.
RESULTS: When comparing the surgical results in the form of the number of complications requiring repeated surgical interventions under anesthesia to eliminate them, corresponding to ClavienDindo 3B complications, a significant difference was obtained in the study groups. The surgical results were significantly better when performing the two-stage Bracka method.
CONCLUSIONS: In the surgical treatment of proximal forms of hypospadias in children, the two-stage Bracka method, where the plastic material for the formation of the artificial urethra is a preputial or mucosal graft, significantly reduced the number of postoperative complications.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. Π₯ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΏΡΠΎΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΡΠΌΠΈ ΡΠΎΡΠΌΠ°ΠΌΠΈ Π³ΠΈΠΏΠΎΡΠΏΠ°Π΄ΠΈΠΈ Π²ΡΠ΅ Π΅ΡΠ΅ ΠΎΡΡΠ°Π΅ΡΡΡ ΡΠ»ΠΎΠΆΠ½ΠΎΠΉ ΠΈ Π²ΠΎ ΠΌΠ½ΠΎΠ³ΠΎΠΌ Π½Π΅ΡΠ΅ΡΠ΅Π½Π½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΎΠΉ. ΠΠΎΠ»ΡΡΠΎΠ΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ, ΠΏΠΎΠ»ΡΡΠ°Π΅ΠΌΡΡ
ΠΏΠΎΡΠ»Π΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΠ΅ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠ²Π½ΡΡ
ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΉ ΠΏΠΎ ΠΏΠΎΠ²ΠΎΠ΄Ρ ΠΏΡΠΎΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΡΡ
ΡΠΎΡΠΌ Π³ΠΈΠΏΠΎΡΠΏΠ°Π΄ΠΈΠΈ, ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΈΠ²Π°Π΅Ρ Π½Π°ΡΡΠ½ΡΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ ΠΊ ΡΡΠΎΠΌΡ Π²ΠΎΠΏΡΠΎΡΡ.
Π¦Π΅Π»Ρ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π΄Π²ΡΡ
ΡΠΈΠΏΠΎΠ² ΡΡΠ΅ΡΡΠΎΠΏΠ»Π°ΡΡΠΈΠΊΠΈ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ ΠΏΡΠΈΠ½ΡΠΈΠΏΠΈΡΠ½ΠΎ ΡΠ°Π·Π½ΡΡ
ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΊ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π°ΡΡΠΈΡΠΈΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΡΠ΅ΡΡΡ, Π° ΠΈΠΌΠ΅Π½Π½ΠΎ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊ, Π² ΠΊΠΎΡΠΎΡΡΡ
ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΡΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΉ ΠΏΠΎ Π²ΠΈΠ΄Ρ ΠΏΠ΅ΡΠ΅ΠΌΠ΅ΡΠ΅Π½ΠΈΡ ΠΈ ΠΊΡΠΎΠ²ΠΎΡΠ½Π°Π±ΠΆΠ΅Π½ΠΈΡ ΠΏΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π» Π»ΠΎΡΠΊΡΡ ΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°Ρ.
ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ 113 ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΏΡΠΎΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΡΠΎΡΠΌΠΎΠΉ Π³ΠΈΠΏΠΎΡΠΏΠ°Π΄ΠΈΠΈ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 8 ΠΌΠ΅Ρ. Π΄ΠΎ 15 Π»Π΅Ρ, ΠΏΡΠΎΠΎΠΏΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π² ΠΏΠ΅ΡΠΈΠΎΠ΄ Ρ 2013 ΠΏΠΎ 2019 Π³. ΠΡΠΈ ΡΡΠΎΠΌ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΎ Π΄Π²Π΅ Π³ΡΡΠΏΠΏΡ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ. Π ΠΏΠ΅ΡΠ²ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ 53 (46,9 %) ΠΌΠ°Π»ΡΡΠΈΠΊΠ°ΠΌ Π±ΡΠ»Π° Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° ΠΎΠ΄Π½ΠΎΡΡΠ°ΠΏΠ½Π°Ρ ΡΡΠ΅ΡΡΠΎΠΏΠ»Π°ΡΡΠΈΠΊΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ onlay-tube, Π³Π΄Π΅ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΏΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° Π±ΡΠ» ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ ΠΏΡΠΎΠ΄ΠΎΠ»ΡΠ½ΡΠΉ ΠΊΠΎΠΆΠ½ΡΠΉ Π»ΠΎΡΠΊΡΡ Π΄ΠΎΡΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ ΠΏΠΎΠ»ΠΎΠ²ΠΎΠ³ΠΎ ΡΠ»Π΅Π½Π°. ΠΠΎ Π²ΡΠΎΡΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ 60 (53,1 %) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌ Π±ΡΠ»Π° ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π° Π΄Π²ΡΡ
ΡΡΠ°ΠΏΠ½Π°Ρ ΡΡΠ΅ΡΡΠΎΠΏΠ»Π°ΡΡΠΈΠΊΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Bracka, Π³Π΄Π΅ ΠΏΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠΌ Π΄Π»Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π°ΡΡΠΈΡΠΈΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΡΠ΅ΡΡΡ ΡΠ»ΡΠΆΠΈΠ» ΠΏΡΠ΅ΠΏΡΡΠΈΠ°Π»ΡΠ½ΡΠΉ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°Ρ Π² 44 (73,3 %) ΡΠ»ΡΡΠ°ΡΡ
ΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°Ρ ΡΠ»ΠΈΠ·ΠΈΡΡΠΎΠΉ ΡΠΎΡΠΎΠ²ΠΎΠΉ ΠΏΠΎΠ»ΠΎΡΡΠΈ Π² 16 (26,7%).
Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠΈ ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² Π² Π²ΠΈΠ΄Π΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ, ΡΡΠ΅Π±ΡΡΡΠΈΡ
ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎΠ³ΠΎ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° ΠΏΠΎΠ΄ Π½Π°ΡΠΊΠΎΠ·ΠΎΠΌ Π΄Π»Ρ ΠΈΡ
ΡΡΡΡΠ°Π½Π΅Π½ΠΈΡ, ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΡ
ΡΡΠ΅ΠΏΠ΅Π½ΠΈ 3Π ΠΏΠΎ ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΠΎΠΉ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Clavien Dindo, ΠΏΠΎΠ»ΡΡΠ΅Π½Π° Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½Π°Ρ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ°Π·Π½ΠΈΡΠ° Π² ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ
Π³ΡΡΠΏΠΏΠ°Ρ
. ΠΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ Π΄Π²ΡΡ
ΡΡΠ°ΠΏΠ½ΠΎΠΉ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ Bracka Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π±ΡΠ»ΠΈ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ Π»ΡΡΡΠ΅.
ΠΡΠ²ΠΎΠ΄Ρ. ΠΡΠΈ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΏΡΠΎΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΡΠΌΠΈ ΡΠΎΡΠΌΠ°ΠΌΠΈ Π³ΠΈΠΏΠΎΡΠΏΠ°Π΄ΠΈΠΈ, ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π΄Π²ΡΡ
ΡΡΠ°ΠΏΠ½ΠΎΠΉ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ Bracka, Π³Π΄Π΅ ΠΏΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠΌ Π΄Π»Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π°ΡΡΠΈΡΠΈΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΡΠ΅ΡΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΡΠ΅ΠΏΡΡΠΈΠ°Π»ΡΠ½ΡΠΉ ΠΈΠ»ΠΈ ΡΠ»ΠΈΠ·ΠΈΡΡΡΠΉ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°Ρ, Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΡΠΌΠ΅Π½ΡΡΠ°Π΅Ρ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ
HIGH VOLTAGE AC PLASMA TORCH OPERATING ON VAPORS OF ORGANIC SUBSTANCES
99-99The report deals with a three-phase high-voltage plasma torch with separate supply of gases and vapors during its operation on a mixture of steam, carbon dioxide, methane and chlorobenzene vapors. Increase in the chlorobenzene flow rate leads to increase in the arc voltage drop and electric power from 100 to 140 kW