112 research outputs found
Development of the High-purity Aluminium Oxide Powder Producing Technology on the Ural Region Raw Materials Basis
This article considers an effective way of complex alumina-containing materials of natural or technogenic origin processing with obtaining a whole complex of raw materials: alkali-free highly active aluminum hydroxide, iron hydroxide, aluminum hydroxide, etc. In laboratory conditions the alumina raw materials behavior in the thickening, washing, filtration processes were checked. The optimal parameters of the processes were selected as a result of conducted research.
Keywords: non-conventional alumina raw materials, technogenic materials, hydrochemical processing, ammonium hydrosulfate, environmental friendliness, efficienc
Optimizing the Conditions of Mechanochemical Synthesis of LiAl Layered Hydroxides
AbstractLiAl layered double hydroxides (LDH) are the promising compounds for application in base catalysis and as precursors of the supports for platinum catalysts. In the work, such systems were synthesized by mechanochemical method. The effect of composition of the initial mixture (Al(OH)3, Al(NO3)3, LiOH, LiNO3), material of milling bodies (steel or ceramic), and activation conditions (centripetal acceleration and activation time) on the properties of LiAl-LDH were studied. It was found that each of the synthesized systems is a polyphase one and contains not only the LDH phase but also the side phase of aluminum trihydroxide. In addition, the samples obtained with the use of steel milling bodies have a substantial amount of iron. The use of ceramic milling bodies makes it possible to obtain the LiAl-LDH phase under relatively mild conditions (acceleration of 300 m/s2 and activation time of 15min)
Two body problem on two point homogeneous spaces, invariant differential operators and the mass center concept
We consider the two body problem with central interaction on two point
homogeneous spaces from point of view of the invariant differential operators
theory. The representation of the two particle Hamiltonian in terms of the
radial differential operator and invariant operators on the symmetry group is
found. The connection of different mass center definitions for these spaces to
the obtained expression for Hamiltonian operator is studied.Comment: 26 pages, LaTeX, no figures, text improve
Exchange Bias in FeMn/M (M = FeNi, Gd, Tb) Films
AbstractMicrostructure and hysteretic properties of magnetic multilayers were studied for Fe50Mn50/M structures, where M = Fe19Ni81, Gd or Tb. Comparative analysis of the hysteresis loops measured for the temperature range 5Γ·350K showed that Gd is not involved in the interlayer exchange coupling with antiferromagnetic Fe50Mn50 layer, while in the case of Tb definite indications of such interaction were observed. It is assumed that a qualitative difference in the magnetic behavior of these rare earth layers can be caused by differences in their structural features
ΠΠΎΠ΄Π½ΡΠΉ ΡΠ΅ΠΆΠΈΠΌ ΡΠ²Π΅ΡΠ»ΠΎ-ΠΊΠ°ΡΡΠ°Π½ΠΎΠ²ΡΡ ΠΏΠΎΡΠ² ΠΏΡΠΈ Π²ΠΎΠ·Π΄Π΅Π»ΡΠ²Π°Π½ΠΈΠΈ ΡΡΠΎΠ»ΠΎΠ²ΠΎΠΉ ΡΠ²Π΅ΠΊΠ»Ρ
Special attention in our studies was paid to conditions of formation of water and soil nutrient regimes, as basic elements in regulation of the production process beet under irrigation in order to obtain the planned harvest of the Centre in range 40...100 t/ha. With irrigation sprinkler canteen beet on light chestnut soils and maintaining before irrigation humidity level 80-80-70% (F.C.) with differentiated depth irrigation 0,3 to 0,6 m and Making N320P175K145 ensures yield commodity Roots till 111,5 t/ha. The combination of controllable factors on the yield of table beet economically and energetically favorable.Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ
Π±ΡΠ»ΠΎ ΡΠ΄Π΅Π»Π΅Π½ΠΎ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΡΠ»ΠΎΠ²ΠΈΡΠΌ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈ ΠΏΠΈΡΠ΅Π²ΠΎΠ³ΠΎ ΡΠ΅ΠΆΠΈΠΌΠΎΠ² ΠΏΠΎΡΠ²Ρ ΠΊΠ°ΠΊ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΡΠ΅Π³ΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΡΡΠΎΠ»ΠΎΠ²ΠΎΠΉ ΡΠ²Π΅ΠΊΠ»Ρ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΎΡΠΎΡΠ΅Π½ΠΈΡ Ρ ΡΠ΅Π»ΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΏΠ»Π°Π½ΠΈΡΡΠ΅ΠΌΠΎΠΉ ΡΡΠΎΠΆΠ°ΠΉΠ½ΠΎΡΡΠΈ Π² ΠΏΡΠ΅Π΄Π΅Π»Π°Ρ
40...100 Ρ/Π³Π°. ΠΡΠΈ ΠΎΡΠΎΡΠ΅Π½ΠΈΠΈ Π΄ΠΎΠΆΠ΄Π΅Π²Π°Π½ΠΈΠ΅ΠΌ ΡΡΠΎΠ»ΠΎΠ²ΠΎΠΉ ΡΠ²Π΅ΠΊΠ»Ρ Π½Π° ΡΠ²Π΅ΡΠ»ΠΎ-ΠΊΠ°ΡΡΠ°Π½ΠΎΠ²ΡΡ
ΠΏΠΎΡΠ²Π°Ρ
ΠΈ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠ°Π½ΠΈΠΈ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΈΠ²Π½ΠΎΠΉ Π²Π»Π°ΠΆΠ½ΠΎΡΡΠΈ Π½Π° ΡΡΠΎΠ²Π½Π΅ 80...80...70% Π½Π°ΠΈΠΌΠ΅Π½ΡΡΠ΅ΠΉ Π²Π»Π°Π³ΠΎΠ΅ΠΌΠΊΠΎΡΡΠΈ (ΠΠ) Ρ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π³Π»ΡΠ±ΠΈΠ½ΠΎΠΉ ΠΎΡΠΎΡΠ΅Π½ΠΈΡ ΠΎΡ 0,3 Π΄ΠΎ 0,6 ΠΌ ΠΈ Π²Π½Π΅ΡΠ΅Π½ΠΈΠΈ N320P175K145 ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅ΡΡΡ ΡΡΠΎΠΆΠ°ΠΉΠ½ΠΎΡΡΡ ΡΠΎΠ²Π°ΡΠ½ΡΡ
ΠΊΠΎΡΠ½Π΅ΠΏΠ»ΠΎΠ΄ΠΎΠ² Π΄ΠΎ 111,5 Ρ/Π³Π°. Π‘ΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ ΡΠΏΡΠ°Π²Π»ΡΠ΅ΠΌΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π° ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠΎΠΆΠ°ΠΉΠ½ΠΎΡΡΠΈ ΡΡΠΎΠ»ΠΎΠ²ΠΎΠΉ ΡΠ²Π΅ΠΊΠ»Ρ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈ ΠΈ ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΈ Π²ΡΠ³ΠΎΠ΄Π½ΠΎ
POLYARTISTISM AS A PERSPECTIVE INNOVATIVE MEANS OF FORMING PROFESSIONALISMA
Π ΡΡΠ°ΡΡΠ΅ Π°ΠΊΡΡΠ°Π»ΠΈΠ·ΠΈΡΡΠ΅ΡΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈΡ ΠΏΠΎΠ»ΠΈΠ°ΡΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π² ΠΎΠ±Π»Π°ΡΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡThe article actualizes the possibility of incorporating polyartistic technologies into the field of vocational educatio
ΠΠ»Π΅ΡΠΎΡΠ½Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ ΠΏΡΠΈ ΡΡΠ°Π²ΠΌΠ°Ρ ΡΠΏΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°
The opportunities and the most promising ways of using cellular technology in traumatic spinal cord injury are considered in this review. A large number of experimental and clinical studies with the use of different types of cells: embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, Schwann cells, olfactory mucosa cells, and others β was conducted. The use of these types of cells in traumatic spinal cord injury treatment often demonstrated a positive therapeutic effect: the motor and sensory function recovery of the spinal cord. However, some types of cell preparations involve some methodological and ethical problems; some types of cell therapies are ineffective or giveΒ rise to side effects. These factors complicate the selection of optimal cell therapy for the traumatic spinal cord injury treatment. The most promising cells seem to be the cells of the olfactory mucosa. Getting the olfactory mucosa is considered to be a feasible and safe procedure for patients. The clinical application of the cells of the olfactory mucosa is effective in motor function recovery due to remyelination and axonal regeneration after spinal cord injury. These cells are tissue-specific and autologous since they can be obtained from a patient with spinal cord injury, and after cultivation, expansion, and directed differentiation they can be transplanted to the same patient. The presented benefits of olfactory mucosa cells open up the possibility for its clinical application in the cell therapy.Β Π ΠΎΠ±Π·ΠΎΡΠ΅ ΡΠ΄Π΅Π»ΡΠ΅ΡΡΡ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΠΌ ΠΈ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡΠΌ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΡΠΈ ΡΡΠ°Π²ΠΌΠ°Ρ
ΡΠΏΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΡΠ°Π±ΠΎΡ ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠΈΠΏΠΎΠ² ΠΊΠ»Π΅ΡΠΎΠΊ β ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ
, ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΏΠ»ΡΡΠΈΠΏΠΎΡΠ΅Π½ΡΠ½ΡΡ
, ΠΌΠ΅Π·Π΅Π½Ρ
ΠΈΠΌΠ°Π»ΡΠ½ΡΡ
ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ
, Π¨Π²Π°Π½Π½ΠΎΠ²ΡΠΊΠΈΡ
, ΠΊΠ»Π΅ΡΠΎΠΊ ΠΎΠ±ΠΎΠ½ΡΡΠ΅Π»ΡΠ½ΠΎΠΉ Π²ΡΡΡΠΈΠ»ΠΊΠΈ ΠΈ Π΄Ρ. β ΠΏΡΠΈ ΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡΡ
ΡΠΏΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° Π²ΠΎ ΠΌΠ½ΠΎΠ³ΠΈΡ
ΡΠ»ΡΡΠ°ΡΡ
ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡ Ρ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ ΡΠ΅Π½ΡΠΎΡΠ½ΠΎΠΉ ΠΈ ΠΌΠΎΡΠΎΡΠ½ΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΉ ΡΠΏΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°. ΠΠ΄Π½Π°ΠΊΠΎ ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ, ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΈ ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ°ΠΌΠΈ, Π° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
ΡΠΈΠΏΠΎΠ² ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠ°Π»ΠΎΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΠΈΠ»ΠΈ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π½Π΅ΠΆΠ΅Π»Π°ΡΠ΅Π»ΡΠ½ΡΠΌ ΠΏΠΎΠ±ΠΎΡΠ½ΡΠΌ ΡΡΡΠ΅ΠΊΡΠ°ΠΌ. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ ΡΠ΅Π±Ρ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΎΠ±ΠΎΠ½ΡΡΠ΅Π»ΡΠ½ΠΎΠΉ Π²ΡΡΡΠΈΠ»ΠΊΠΈ, ΠΏΡΠΈ ΡΡΠΎΠΌ ΠΏΡΠΎΡΠ΅Π΄ΡΡΠ° ΠΈΡ
ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π΄ΠΎΡΡΡΠΏΠ½Π° ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½Π° Π΄Π»Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΎΠ±ΠΎΠ½ΡΡΠ΅Π»ΡΠ½ΠΎΠΉ Π²ΡΡΡΠΈΠ»ΠΊΠΈ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ Π΄Π»Ρ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ Π΄Π²ΠΈΠ³Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ Π²ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ ΡΠ΅ΠΌΠΈΠ΅Π»ΠΈΠ½ΠΈΠ·Π°ΡΠΈΠΈ ΠΈ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ Π°ΠΊΡΠΎΠ½ΠΎΠ² ΠΏΠΎΡΠ»Π΅ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΡΠΏΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°. ΠΠ°Π½Π½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΡΠ²Π»ΡΡΡΡΡ ΡΠΊΠ°Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΡΠΌΠΈ ΠΈ Π°ΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΡΠΌΠΈ, ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ ΠΎΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° Ρ ΡΡΠ°Π²ΠΌΠΎΠΉ ΡΠΏΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΠΈ ΠΏΠΎΡΠ»Π΅ Π½Π°ΡΠ°ΡΠΈΠ²Π°Π½ΠΈΡ Π² ΠΊΡΠ»ΡΡΡΡΠ΅ ΠΈ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠΈΡΠΎΠ²Π°Π½Ρ ΡΠΎΠΌΡ ΠΆΠ΅ ΡΠ°ΠΌΠΎΠΌΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ. Π’Π°ΠΊΠΈΠ΅ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΊΠ»Π΅ΡΠΎΠΊ ΠΎΠ±ΠΎΠ½ΡΡΠ΅Π»ΡΠ½ΠΎΠΉ Π²ΡΡΡΠΈΠ»ΠΊΠΈ ΠΎΡΠΊΡΡΠ²Π°ΡΡ ΡΠΈΡΠΎΠΊΠΈΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈΡ
ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΡΠΈ ΡΡΠ°Π²ΠΌΠ°Ρ
ΡΠΏΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°
Cultural Eco-Restructuring of Resource-Producing Objects of Landscape Territories
It is proposed to include in the circle of theoretical and practical scientific concepts of cultural studies a new analogue logotyped term Β«cultural eco-restructuringΒ». This is justified by the fact that in the space of resource-producing territories, it becomes possible to eco-restructure resource-producing objects in order to form optimized socio-cultural objects on their basis. Attention is also drawn to certain characteristics of this term-logo, which are revealed in the aspect of attracting the attention of society to the actualization of a particular environmental problem, increasing the attractiveness of the formulation of the environmental issue being addressed.ΠΡΠ΅Π΄Π»Π°Π³Π°Π΅ΡΡΡ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π² ΠΊΡΡΠ³ ΡΠ΅ΠΎΡΠ΅ΡΠΈΠΊΠΎ-ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π½Π°ΡΡΠ½ΡΡ
ΠΏΠΎΠ½ΡΡΠΈΠΉ ΠΊΡΠ»ΡΡΡΡΠΎΠ»ΠΎΠ³ΠΈΠΈ Π½ΠΎΠ²ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΎΠ³ΠΎΠ²ΠΎΠ³ΠΎ Π»ΠΎΠ³ΠΎΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΠΌΠΈΠ½Π° Β«ΠΊΡΠ»ΡΡΡΡΠ½Π°Ρ ΡΠΊΠΎΡΠ΅ΡΡΡΡΠΊΡΡΡΠΈΠ·Π°ΡΠΈΡΒ». ΠΠ±ΠΎΡΠ½ΠΎΠ²ΡΠ²Π°Π΅ΡΡΡ ΡΡΠΎ ΡΠ΅ΠΌ, ΡΡΠΎ Π² ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅ ΡΠ΅ΡΡΡΡΠΎΠ΄ΠΎΠ±ΡΠ²Π°ΡΡΠΈΡ
ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠΉ ΠΏΠΎΡΠ²Π»ΡΠ΅ΡΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΡΠΊΠΎΡΠ΅ΡΡΡΡΠΊΡΡΡΠΈΠ·Π°ΡΠΈΠΈ ΡΠ΅ΡΡΡΡΠΎΠ΄ΠΎΠ±ΡΠ²Π°ΡΡΠΈΡ
ΠΎΠ±ΡΠ΅ΠΊΡΠΎΠ² Ρ ΡΠ΅Π»ΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π° ΠΈΡ
ΠΎΡΠ½ΠΎΠ²Π΅ ΠΎΠΏΡΠΈΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΎΠ±ΡΠ΅ΠΊΡΠΎΠ² ΡΠΎΡΠΈΠΎΠΊΡΠ»ΡΡΡΡΠ½ΠΎΠ³ΠΎ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΡ. Π’Π°ΠΊΠΆΠ΅ ΠΎΠ±ΡΠ°ΡΠ°Π΅ΡΡΡ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ Π½Π° ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΠΌΠΈΠ½Π°-Π»ΠΎΠ³ΠΎΡΠΈΠΏΠ°, ΡΠ°ΡΠΊΡΡΠ²Π°ΡΡΠΈΠ΅ΡΡ Π² Π°ΡΠΏΠ΅ΠΊΡΠ΅ ΠΏΡΠΈΠ²Π»Π΅ΡΠ΅Π½ΠΈΡ Π²Π½ΠΈΠΌΠ°Π½ΠΈΡ ΡΠΎΡΠΈΡΠΌΠ° ΠΊ Π°ΠΊΡΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΡΠΎΠΉ ΠΈΠ»ΠΈ ΠΈΠ½ΠΎΠΉ ΡΠΊΠΎΠΏΡΠΎΠ±Π»Π΅ΠΌΡ, ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠΈ Π°ΡΡΡΠ°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΎΡΠΌΡΠ»ΠΈΡΠΎΠ²ΠΊΠΈ ΡΠ΅ΡΠ°Π΅ΠΌΠΎΠ³ΠΎ ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΎΠΏΡΠΎΡΠ°
ΠΠ‘ΠΠΠΠ’Π« ΠΠ ΠΠΠΠΠΠΠΠ― ΠΠΠΠΠΠΠ’ΠΠ¦ΠΠΠ Π ΠΠΠΠΠ¦ΠΠΠ Π Π€ΠΠ ΠΠΠ¦ΠΠ
Indomethacin, a non-steroid anti-inflammatory drug (NSAID), has been used in different spheres of medicine since the 1960s. It is successfully administered as an anti-inflammatory and pain-relieving medication in rheumatoid and other diseases. According to recent research, indomethacin may become a promising drug enhancing endogenous remyelination in patients with multiple sclerosis. Also, indomethacin affects cell proliferation and invasion, thus it is used to manage pancreatic cancer in patients with hyperglycemia. In addition, indomethacin can inhibit protein synthesis in colorectal carcinoma and other types of cancer cells. The article reviews modern indomethacin medications and the different dosage forms on the Russian pharmaceutical market. Indomethacin poor water solubility is one of the reasons for decreasing its biopharmaceutical characteristics. According to the conducted research, a prospective way to improve indomethacin solubility and bioavailability is the Solid Dispersion (SD) method. SDs are bi- or multicomponent systems consisting of the drug and the carrier. They are a highly dispersed solid phase of the drug or molecular-dispersed solid solutions with a partial formation of a variable composition complex and a carrier. The article provides a brief overview on different aspects of obtaining, investigating, and applying indomethacin SDs with various polymers.Π‘ΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ Π² ΡΠ΅ΡΡΠΈΠ΄Π΅ΡΡΡΡΡ
Π³ΠΎΠ΄Π°Ρ
ΠΏΡΠΎΡΠ»ΠΎΠ³ΠΎ ΡΡΠΎΠ»Π΅ΡΠΈΡ ΡΠΈΠΏΠΈΡΠ½ΡΠΉ ΠΏΡΠ΅Π΄ΡΡΠ°Π²ΠΈΡΠ΅Π»Ρ ΠΊΠ»Π°ΡΡΠ° Π½Π΅ΡΡΠ΅ΡΠΎΠΈΠ΄Π½ΡΡ
ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ² ΠΈΠ½Π΄ΠΎΠΌΠ΅ΡΠ°ΡΠΈΠ½ Π½Π°ΡΠ΅Π» ΡΠΈΡΠΎΠΊΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΎΠ±Π»Π°ΡΡΡΡ
ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ. Π‘ΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΠΎΠ±Π΅Π·Π±ΠΎΠ»ΠΈΠ²Π°ΡΡΠ΅Π³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΎΠ±ΡΡΠ»ΠΎΠ²ΠΈΠ»ΠΎ ΡΡΠΏΠ΅ΡΠ½ΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΈΠ½Π΄ΠΎΠΌΠ΅ΡΠ°ΡΠΈΠ½Π° ΠΏΡΠΈ ΡΠ΅Π²ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ
. ΠΠΎΠ²Π΅ΠΉΡΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π²ΡΡΠ²ΠΈΠ»ΠΈ, ΡΡΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ ΠΌΠΎΠΆΠ΅Ρ ΡΡΠ°ΡΡ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ ΠΈ Π² ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΡΠ΄Π° ΠΈΠ½ΡΡ
ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΉ. Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½ ΠΊΡΠ°ΡΠΊΠΈΠΉ ΠΎΠ±Π·ΠΎΡ Π°ΡΡΠΎΡΡΠΈΠΌΠ΅Π½ΡΠ° ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΠΎΡΠΌ ΠΈΠ½Π΄ΠΎΠΌΠ΅ΡΠ°ΡΠΈΠ½Π° Π½Π° ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΌ ΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΡΠ½ΠΊΠ΅. ΠΠ΄Π½ΠΈΠΌ ΠΈΠ· ΡΠ°ΠΊΡΠΎΡΠΎΠ², ΡΠ½ΠΈΠΆΠ°ΡΡΠΈΡ
Π±ΠΈΠΎΡΠ°ΡΠΌΠ°ΡΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΈΠ½Π΄ΠΎΠΌΠ΅ΡΠ°ΡΠΈΠ½Π°, ΡΠ²Π»ΡΠ΅ΡΡΡ Π΅Π³ΠΎ ΠΌΠ°Π»Π°Ρ ΡΠ°ΡΡΠ²ΠΎΡΠΈΠΌΠΎΡΡΡ Π² Π²ΠΎΠ΄Π΅. Π‘ΠΎΠ³Π»Π°ΡΠ½ΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ Π°Π½Π°Π»ΠΈΠ·Π° Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ½ΡΡ
Π΄Π°Π½Π½ΡΡ
, ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ, ΡΠΏΠΎΡΠΎΠ±Π½ΡΡ
ΡΡΠΏΠ΅ΡΠ½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠΈΡΡ ΡΠ°ΡΡΠ²ΠΎΡΠΈΠΌΠΎΡΡΡ ΠΈ Π±ΠΈΠΎΠ΄ΠΎΡΡΡΠΏΠ½ΠΎΡΡΡ ΠΈΠ½Π΄ΠΎΠΌΠ΅ΡΠ°ΡΠΈΠ½Π°, ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΌΠ΅ΡΠΎΠ΄ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π΅Π³ΠΎ ΡΠ²Π΅ΡΠ΄ΡΡ
Π΄ΠΈΡΠΏΠ΅ΡΡΠΈΠΉ. Π’Π²Π΅ΡΠ΄ΡΠ΅ Π΄ΠΈΡΠΏΠ΅ΡΡΠΈΠΈ β ΡΡΠΎ Π±ΠΈ- ΠΈΠ»ΠΈ ΠΌΠ½ΠΎΠ³ΠΎΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ½ΡΠ΅ ΡΠΈΡΡΠ΅ΠΌΡ ΠΈΠ· Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ Π²Π΅ΡΠ΅ΡΡΠ²Π° ΠΈ Π½ΠΎΡΠΈΡΠ΅Π»Ρ, ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡΠΈΠ΅ ΡΠΎΠ±ΠΎΠΉ Π²ΡΡΠΎΠΊΠΎΠ΄ΠΈΡΠΏΠ΅ΡΠ³ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΡΠ²Π΅ΡΠ΄ΡΡ ΡΠ°Π·Ρ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ Π²Π΅ΡΠ΅ΡΡΠ²Π° ΠΈΠ»ΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π΄ΠΈΡΠΏΠ΅ΡΡΠ½ΡΠ΅ ΡΠ²Π΅ΡΠ΄ΡΠ΅ ΠΈΠ»ΠΈ ΠΆΠΈΠ΄ΠΊΠΈΠ΅ ΡΠ°ΡΡΠ²ΠΎΡΡ Ρ ΡΠ°ΡΡΠΈΡΠ½ΡΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² ΠΏΠ΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° Ρ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠΌ Π½ΠΎΡΠΈΡΠ΅Π»Ρ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ ΠΊΡΠ°ΡΠΊΠΈΠΉ ΠΎΠ±Π·ΠΎΡ ΡΠ°Π±ΠΎΡ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΡ
ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌ Π°ΡΠΏΠ΅ΠΊΡΠ°ΠΌ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ, ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ²Π΅ΡΠ΄ΡΡ
Π΄ΠΈΡΠΏΠ΅ΡΡΠΈΠΉ ΠΈΠ½Π΄ΠΎΠΌΠ΅ΡΠ°ΡΠΈΠ½Π° Ρ ΡΠ°Π·Π½ΡΠΌΠΈ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°ΠΌΠΈ-Π½ΠΎΡΠΈΡΠ΅Π»ΡΠΌΠΈ
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