12 research outputs found

    DIAGNOSIS OF PARAURETHRAL CYSTS

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    BIOMARKERS OF THE ALLERGIC INFLAMMATION AS ADDITIONAL CRITERIA FOR THE ASTHMA CONTROL

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    The authors have carried on a prospective open comparative study within the parallel groups to assess the dynamics of the markers of the inflammation among the patients with various degree of bronchial asthma severity against the background of the anti-inflammatory therapy and define the role of nitrogen oxide in respiratory condensate as a biomarker during the bronchial asthma. All the patients (n = 54) have undergone determination of the bronchial hypere activity level, nitrite level in respiratory condensate, relative number of eosinophiles of nasal secretion against the background of the anti-inflammatory basic therapy application adequate to the degree of bronchial asthma severity. the researchers have revealed that application of the anti-inflammatory basic therapy adequate to the degree of bronchial asthma severity led to achievement of the criteria for the control over bronchial asthma symptoms among the majority of patients already towards the end of the 12th week. Nevertheless, the accurate reduction of biomarkers of allergic inflammation was registered only in the end of the treatment period (24 weeks). Thus, the application of the anti-inflammatory basic therapy adequate to the degree of bronchial asthma severity is necessary within no less than 24 weeks. It helps to achieve the control over symptoms of the disease, as well as it is accompanied by the accurate reduction of biomarkers of atopic inflammation, and there? Fore, it leads to the activity reduction of the respiratory tract inflammation. Biomarkers may be used not only for the purpose to assess the inflammation of the respiratory passages, but also as a marker for the asthma therapy effectiveness, which can allow optimizing the bronchial asthma therapy among children.Key words: bronchial asthma, children, atopic inflammation, bio-markers, nitrogen oxide, eosinophiles, bronchial hyperreactivity

    БИОЛОГИЧЕСКИЕ МАРКЁРЫ АЛЛЕРГИЧЕСКОГО ВОСПАЛЕНИЯ КАК ДОПОЛНИТЕЛЬНЫЕ КРИТЕРИИ КОНТРОЛЯ БРОНХИАЛЬНОЙ АСТМЫ

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    The authors have carried on a prospective open comparative study within the parallel groups to assess the dynamics of the markers of the inflammation among the patients with various degree of bronchial asthma severity against the background of the anti-inflammatory therapy and define the role of nitrogen oxide in respiratory condensate as a biomarker during the bronchial asthma. All the patients (n = 54) have undergone determination of the bronchial hypere activity level, nitrite level in respiratory condensate, relative number of eosinophiles of nasal secretion against the background of the anti-inflammatory basic therapy application adequate to the degree of bronchial asthma severity. the researchers have revealed that application of the anti-inflammatory basic therapy adequate to the degree of bronchial asthma severity led to achievement of the criteria for the control over bronchial asthma symptoms among the majority of patients already towards the end of the 12th week. Nevertheless, the accurate reduction of biomarkers of allergic inflammation was registered only in the end of the treatment period (24 weeks). Thus, the application of the anti-inflammatory basic therapy adequate to the degree of bronchial asthma severity is necessary within no less than 24 weeks. It helps to achieve the control over symptoms of the disease, as well as it is accompanied by the accurate reduction of biomarkers of atopic inflammation, and there? Fore, it leads to the activity reduction of the respiratory tract inflammation. Biomarkers may be used not only for the purpose to assess the inflammation of the respiratory passages, but also as a marker for the asthma therapy effectiveness, which can allow optimizing the bronchial asthma therapy among children.Key words: bronchial asthma, children, atopic inflammation, bio-markers, nitrogen oxide, eosinophiles, bronchial hyperreactivity.Проведено проспективное открытое сравнительное исследование в параллельных группах с целью оценить динамику маркёров воспаления у больных с разной тяжестью бронхиальной астмы (БА) на фоне противовоспалительной терапии и установить роль оксида азота в дыхательном конденсате как биологического маркёра при БА. Всем пациентам (n = 54) было проведено определение уровня бронхиальной гиперреактивности, уровень нитритов в дыхательном конденсате, относительное количество эозинофилов назального секрета на фоне использования противовоспалительной базисной терапии, адекватной степени тяжести БА. Установлено, что использование противовоспалительной базисной терапии, адекватной степени тяжести заболевания, уже к концу 12 нед терапии приводило к достижению критериев контроля над симптомами БА у большинства пациентов. Однако достоверное снижение биологических маркёров аллергического воспаления отмечено лишь по окончании лечебного периода (24 нед). Таким образом, использование противовоспалительной базисной терапии, адекватной степени тяжести БА, необходимо в течение не менее 24 нед. Это способствует достижению контроля над симптомами болезни и сопровождается достоверным снижением биологических маркёров атопического воспаления, а значит, приводит к снижению активности воспаления респираторного тракта. Биологические маркёры возможно использовать не только с целью оценки активности воспаления дыхательных путей, но в качестве маркёра эффективности терапии астмы, что позволит оптимизировать терапию БА у детей. Ключевые слова: бронхиальная астма, дети, атопическое воспаление, биологические маркёры, оксид азота, эозинофилы, бронхиальная гиперреактивность.(Педиатрическая фармакология. – 2006; 3(5):9-13
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