Українсько-угорські відносини в контексті євроатлантичної інтеграції України (Ukrainian-hungarian relations in the context of Ukraine’s euro-atlantic integration)

У статті досліджено характерні ознаки українсько-угорських відносин на фоні євроатлантичної інтеграції України. Розглянуто ключові етапи взаємозв’язків між Україною та Угорщиною з часу їх становлення до сьогодення, проаналізовано причини та наслідки їх загострення. Зроблено прогноз щодо розвитку двосторонніх взаємин між державами у короткостроковій перспективі. (In article, the characteristic features of Ukrainian-Hungarian relations on the background of Ukraine’s Euro-Atlantic integration are examined. The key stages of the relationship between Ukraine and Hungary since the time of their formation till the presentday are considered, the reasons and consequences of their exacerbation are analyzed. The forecast for the development of bilateral relations between the states in the short term is made.

The impact of postoperative complications and implication of a multimodal enhanced recovery programme on long-term outcomes of surgical treatment of colon cancer patients

Application of the multimodal enhanced recovery program (ERP) proved its effectiveness in surgical treatment of patients with colon cancer. The impact of an ERP on the long-term outcomes remains a challenge. Aim of the study: to assess the impact of an ERP on the long-term outcomes of the surgical treatment of colon cancer patients. Object and methods: a total of 230 patients, who underwent curative surgery for colon cancer from 2008 to 2013, were enrolled and divided into main (130 patients) and control group (100 patients). Results: no significant difference in antropometric data, tumor site, disease stage and surgery type was observed. Grade II–IV according to the Clavien — Dindo classification of surgical complications was determined in 11 (8.5%) patients of main group and in 20 (20.0%) patients of control group (р < 0.05) with postoperative mortality 0.8 and 2.0%, respectively (р < 0.05). Overall 3-year survival differed significantly: 88.4 ± 9.6% — in main and 72.2 ± 7.6% — in control group (р < 0.05) with insignificant shift in disease-free survival — 87.0 ± 7.5% and 90.0 ± 10.2%, respectively (р = 2.235). All patients who had grade II–IV complications didn’t achieve 3-year survival, with the median of 28.7 and 26.2 months (р = 1.954). Conclusion: ERP application leads to the improvement of overall survival by means of reduction of grade II–IV Clavien — Dindo complications.Применение мультимодальной программы быстрого восстановления (ПБВ) продемонстрировало свою эффективность в отношении непосредственных результатов хирургического лечения больных раком ободочной кишки. На сегодня влияние ПБВ на отдаленные результаты терапии остается недостаточно изученным. Цель: оценить влияние ПБВ на отдаленные результаты хирургического лечения больных раком ободочной кишки. Объект и методы: включены 230 пациентов, которым в период с 2008 по 2013 г. проводили хирургическое лечение по поводу рака ободочной кишки. В основную группу (хирургическое лечение по ПБВ) включено 130, в группу сравнения (стандартная тактика) — 100 больных. Результаты: значимых межгрупповых различий по антропометрическим данным, локализации опухоли, стадии заболевания и объему оперативного вмешательства не отмечено. Среди пациентов основной группы послеоперационные осложнения II–IV класса по классификации Clavien — Dindo зарегистрированы в 11 (8,5%), а контрольной группы — в 20 (20,0%) случаях (р < 0,05). Послеоперационная летальность составила 0,8 и 2,0% соответственно (р < 0,05). Период наблюдения — 37,4 ± 4,7 мес. Общая 3-летняя выживаемость имела достоверное различие: 88,4 ± 9,6% — в основной и 72,2 ± 7,6% — в контрольной группе (р < 0,05). Общая 3-летняя безрецидивная выживаемость составила 87,0 ± 7,5 и 90,0 ± 10,2% для основной и контрольной группы соответственно (р = 2,235). У пациентов обеих групп, у которых возникли послеоперационные осложнения II–IV класса, 3-летняя выживаемость не достигнута. Медиана — 28,7 и 26,2 мес для основной и контрольной группы соответственно (р = 1,954). Выводы: применяемая ПБВ влияет на отдаленные результаты лечения за счет уменьшения количества послеоперационных осложнений II–IV класса

Laser scanning microscopy of HTS films and devices (Review Article)

The work describes the capabilities of laser scanning microscopy (LSM) as a spatially-resolved method of testing high–Tc materials and devices. The earlier results obtained by the authors are briefly reviewed. Some novel applications of the LSM are illustrated, including imaging the HTS responses in rf mode, probing the superconducting properties of HTS single crystals, development of two-beam laser scanning microscopy. The existence of the phase slip lines mechanism of resistivity in HTS materials is proven by LSM imaging

Reaction of Push-Pull Enaminoketones and in Situ Generated ortho-Quinone Methides: Synthesis of 3-Acyl-4H-chromenes and 2-Acyl-1H-benzo[f]chromenes as Precursors for Hydroxybenzylated Heterocycles

A simple and efficient method for the synthesis of 4H-chromenes and 1H-benzo[f]chromenes containing a trifluoroacetyl or aroyl group in the pyran ring from o-quinone methide precursors and push-pull enaminoketones has been developed. The chromenes are presumably formed through an initial oxa-Diels-Alder reaction, followed by an elimination of amine. The possibility of further transformations of given chromenes to o-hydroxybenzylated pyrazoles, isoxazoles, and pyridines has been demonstrated. © 2017 American Chemical Society

Reactions of 1-[(dimethylamino)methyl]naphthalen-2-ols with cyclic push-pull nitroenamines

[Figure not available: see fulltext.] A method was developed for the synthesis of 1-[2-nitro-2-(pyrrolidin-2-ylidene)ethyl]- and 1-[2-(imidazolidin-2-ylidene)-2-nitroethyl]-naphthalen-2-ols based on a reaction of 1,2-naphthoquinone-1-methide precursors with heterocyclic β-nitroenamines (pyrrolidine and imidazolidine derivatives). © 2018, Springer Science+Business Media, LLC, part of Springer Nature

Reactions of 1-[(dimethylamino)methyl]naphthalen-2-ols with cyclic push-pull nitroenamines

[Figure not available: see fulltext.] A method was developed for the synthesis of 1-[2-nitro-2-(pyrrolidin-2-ylidene)ethyl]- and 1-[2-(imidazolidin-2-ylidene)-2-nitroethyl]-naphthalen-2-ols based on a reaction of 1,2-naphthoquinone-1-methide precursors with heterocyclic β-nitroenamines (pyrrolidine and imidazolidine derivatives). © 2018, Springer Science+Business Media, LLC, part of Springer Nature

Reaction of Push-Pull Enaminoketones and in Situ Generated ortho-Quinone Methides: Synthesis of 3-Acyl-4H-chromenes and 2-Acyl-1H-benzo[f]chromenes as Precursors for Hydroxybenzylated Heterocycles

A simple and efficient method for the synthesis of 4H-chromenes and 1H-benzo[f]chromenes containing a trifluoroacetyl or aroyl group in the pyran ring from o-quinone methide precursors and push-pull enaminoketones has been developed. The chromenes are presumably formed through an initial oxa-Diels-Alder reaction, followed by an elimination of amine. The possibility of further transformations of given chromenes to o-hydroxybenzylated pyrazoles, isoxazoles, and pyridines has been demonstrated. © 2017 American Chemical Society

Synthesis of 8-substituted 1,5-diazabicyclo[3.2.1]octane derivatives via double aza-Michael addition of homopiperazine to 3-trifluoroacetyl-4H-chromenes

The reaction of homopiperazine with 2-trifluoroacetyl-1H-benzo[f]chromenes affords 2-(1,5-diazabicyclo[3.2.1]octan-8-yl)-3-(trifluoromethyl)-2,3-dihydro-1H-benzo[f]chromen-3-ols, while 3-trifluoroacetyl-4H-chromenes give 2-[2-(1,5-diazabicyclo[3.2.1]octan-8-yl)ethyl]phenols. Both reactions are the first examples of synthesis of 1,5-diazabicyclo[3.2.1]octane core via double Michael addition and include cascade Michael addition/pyran ring opening/Michael addition. © 2017 Elsevier B.V

Professional Creativity as A Component of The Effective Activity of a Teacher

The article considers the role and influence of professional creativity on the professional activities as an expression of the teacher's creative abilities. The purpose of the article is a theoretical and empirical study of the influence of professional creativity on the effectiveness of a teacher's professional activity. Attention is paid to the place and importance of creativity in the activities of a teacher. Based on an analysis of current literary sources, the phenomenon of professional creativity of a teacher is highlighted, a definition of this concept is given, and its structure and components are considered. The research methodology and its algorithm include a complex psychological and pedagogical experiment, diagnosing the stated parameters and statistical analysis of the results based on Spearman's rank correlation coefficient. The study of teachers' creativity was carried out on the basis of the Institute of Foreign Languages of the Federal State Autonomous Educational Institution of Higher Education "The Peoples' Friendship University of Russia" (RUDN) at the Center for Continuing Professional Education. For research purposes, an experimental and a control group were formed. Each group consisted of 35 teachers. The sample was homogeneous by age and gender. The results of the study allow us to conclude that there is a strong relationship between the professional creativity of a teacher and the effectiveness of the professional performance, which is confirmed by the results of statistical processing of the data obtained

Synthesis of 8-substituted 1,5-diazabicyclo[3.2.1]octane derivatives via double aza-Michael addition of homopiperazine to 3-trifluoroacetyl-4H-chromenes

The reaction of homopiperazine with 2-trifluoroacetyl-1H-benzo[f]chromenes affords 2-(1,5-diazabicyclo[3.2.1]octan-8-yl)-3-(trifluoromethyl)-2,3-dihydro-1H-benzo[f]chromen-3-ols, while 3-trifluoroacetyl-4H-chromenes give 2-[2-(1,5-diazabicyclo[3.2.1]octan-8-yl)ethyl]phenols. Both reactions are the first examples of synthesis of 1,5-diazabicyclo[3.2.1]octane core via double Michael addition and include cascade Michael addition/pyran ring opening/Michael addition. © 2017 Elsevier B.V