The mineral resources of the English Channel and Thames Estuary

This report accompanies the Marine mineral resource map the marine sand and gravel resources of the English Channel and Thames Estuary (Bide et al, 2012). It has been published as part of the research project Mineral Resource Assessment of the UK Continental Shelf commissioned by The Crown Estate. The map is one of a series that covers the UK Continental Shelf (UKCS). Knowledge of mineral resources is essential for effective and sustainable planning decisions. The marine mineral resource maps provide a comprehensive, relevant and accessible information base. This information will allow all stakeholders (planners, industry and members of the public) to visualise the distribution of offshore minerals to a common standard and at a common scale, an important requirement of an integrated marine planning system. The maps will also facilitate the conservation (safeguarding) of non-renewable mineral resources for future generations in accordance with the principles of sustainable development

Choice, Risk, and Moral Judgment: Using Discourse Analysis to Identify the Moral Component of Midwives’ Discourses

Part 1. Communicating risk in healthcare -- Part 2. Communicating risk in legal processes -- Part 3. Communicating risk in social care -- Part 4. Communicating risk in environmental management and biosecurity -- Part 5. Mediating risk -- Part 6. Regulating risk368 page(s

The mineral resources of the East Inshore and East Offshore marine plan areas, southern North Sea

Minerals are naturally occurring raw materials essential for the development of a modern economy. However, mineral resources are finite and can only be worked where they occur. As their extraction is subject to many constraints, it is important that society uses minerals in the most efficient and sustainable manner. Identifying the distribution of known mineral resources on the UK Continental Shelf (UKCS) and presenting them in a consistent fashion at a national scale allows minerals to be considered in the marine spatial planning process and permits more effective and sustainable management strategies to be developed. The British Geological Survey (BGS) has undertaken a commission from The Crown Estate to prepare a series of mineral resource maps which cover the UKCS. Mineral resource information was compiled following a desk study of data held by the BGS and external sources. This report summarises the mineral resources depicted on the first of these maps - the East Inshore and East Offshore Marine Plan Areas in the southern North Sea. These are the first areas (Figure 1) for which the Marine Management Organisation is preparing marine plans (MMO, 2010). The map has been produced by the collation and interpretation of a wide range of information, much of which is spatially variable and not always available in a consistent and convenient form. The map depicts mineral resources of current or potential future economic interest in the area. It comprises a 1:500 000 scale map (which accompanies this report) depicting marine aggregate (sand and gravel) resources on the sea bed, and two 1:1 500 000 scale maps (as annexes in this report) depicting coal and evaporite resources at depth beneath the sea bed. These map scales are convenient for the overall display of the data. However, all the data are held digitally at larger scales using a Geographical Information System (GIS), which allows for revision, updating and customisation of the information, together with integration with other datasets

Calculation of excited polaron states in the Holstein model

An exact diagonalization technique is used to investigate the low-lying excited polaron states in the Holstein model for the infinite one-dimensional lattice. For moderate values of the adiabatic ratio, a new and comprehensive picture, involving three excited (coherent) polaron bands below the phonon threshold, is obtained. The coherent contribution of the excited states to both the single-electron spectral density and the optical conductivity is evaluated and, due to the invariance of the Hamiltonian under the space inversion, the two are shown to contain complementary information about the single-electron system at zero temperature. The chosen method reveals the connection between the excited bands and the renormalized local phonon excitations of the adiabatic theory, as well as the regime of parameters for which the electron self-energy has notable non-local contributions. Finally, it is shown that the hybridization of two polaron states allows a simple description of the ground and first excited state in the crossover regime.Comment: 12 pages, 9 figures, submitted to PR

Degradation and healing in a generalized neo-Hookean solid due to infusion of a fluid

The mechanical response and load bearing capacity of high performance polymer composites changes due to diffusion of a fluid, temperature, oxidation or the extent of the deformation. Hence, there is a need to study the response of bodies under such degradation mechanisms. In this paper, we study the effect of degradation and healing due to the diffusion of a fluid on the response of a solid which prior to the diffusion can be described by the generalized neo-Hookean model. We show that a generalized neo-Hookean solid - which behaves like an elastic body (i.e., it does not produce entropy) within a purely mechanical context - creeps and stress relaxes when infused with a fluid and behaves like a body whose material properties are time dependent. We specifically investigate the torsion of a generalized neo-Hookean circular cylindrical annulus infused with a fluid. The equations of equilibrium for a generalized neo-Hookean solid are solved together with the convection-diffusion equation for the fluid concentration. Different boundary conditions for the fluid concentration are also considered. We also solve the problem for the case when the diffusivity of the fluid depends on the deformation of the generalized neo-Hookean solid.Comment: 24 pages, 10 figures, submitted to Mechanics of Time-dependent Material

Phosphate steering by Flap Endonuclease 1 promotes 5´-flap specificity and incision to prevent genome instability

DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome integrity, and FEN1 mutations arise in multiple cancers. FEN1 precisely cleaves single-stranded (ss) 50-flaps one nucleotide into duplex (ds) DNA. Yet, how FEN1 selects for but does not incise the ss 50-flap was enigmatic. Here we combine crystallographic, biochemical and genetic analyses to show that two dsDNA binding sites set the 50polarity and to reveal unexpected control of the DNA phosphodiester backbone by electrostatic interactions. Via ‘phosphate steering’, basic residues energetically steer an inverted ss 50-flap through a gateway over FEN1’s active site and shift dsDNA for catalysis. Mutations of these residues cause an 18,000-fold reduction in catalytic rate in vitro and large-scale trinucleotide (GAA)n repeat expansions in vivo, implying failed phosphate-steering promotes an unanticipated lagging-strand template-switch mechanism during replication. Thus, phosphate steering is an unappreciated FEN1 function that enforces 50-flap specificity and catalysis, preventing genomic instability

Phosphate steering by Flap Endonuclease 1 promotes 5´-flap specificity and incision to prevent genome instability

DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome integrity, and FEN1 mutations arise in multiple cancers. FEN1 precisely cleaves single-stranded (ss) 50-flaps one nucleotide into duplex (ds) DNA. Yet, how FEN1 selects for but does not incise the ss 50-flap was enigmatic. Here we combine crystallographic, biochemical and genetic analyses to show that two dsDNA binding sites set the 50polarity and to reveal unexpected control of the DNA phosphodiester backbone by electrostatic interactions. Via ‘phosphate steering’, basic residues energetically steer an inverted ss 50-flap through a gateway over FEN1’s active site and shift dsDNA for catalysis. Mutations of these residues cause an 18,000-fold reduction in catalytic rate in vitro and large-scale trinucleotide (GAA)n repeat expansions in vivo, implying failed phosphate-steering promotes an unanticipated lagging-strand template-switch mechanism during replication. Thus, phosphate steering is an unappreciated FEN1 function that enforces 50-flap specificity and catalysis, preventing genomic instability

Adapting preference-based utility measures to capture the impact of cancer treatment-related symptoms

It is important that patient-reported outcome (PRO) measures used to assess cancer therapies adequately capture the benefits and risks experienced by patients, particularly when adverse event profiles differ across therapies. This study explores the case for augmenting preference-based utility measures to capture the impact of cancer treatment-related symptoms. Additional cancer treatment-related items could be specific (e.g., rash) or global. While specific items are easier to describe and understand, their use may miss rarer symptoms and those that are currently unknown but will arise from future medical advancements. The appropriate number of additional items, the independence of those items, and their impact on the psychometric properties of the core instrument require consideration. Alternatively, a global item could encompass all potential treatment-related symptoms, of any treatments for any disease. However, such an item may not be well understood by general public respondents in valuation exercises. Further challenges include the decision about whether to generate de novo value sets for the modified instrument or to map to existing tariffs. The fluctuating and transient nature of treatment-related symptoms may be inconsistent with the methods used in conventional valuation exercises. Fluctuating symptoms could be missed by sub-optimal measure administration timing. The addition of items also poses double-counting risks. In summary, the addition of treatment-related symptom items could increase the sensitivity of existing utility measures to capture known and unknown treatment effects in oncology, while retaining the core domains. However, more research is needed to investigate the challenges, particularly regarding valuation

The future of sovereignty in multilevel governance Europe: a constructivist reading

Multilevel governance presents a depiction of contemporary structures in EU Europe as consisting of overlapping authorities and competing competencies. By focusing on emerging non-anarchical structures in the international system, hence moving beyond the conventional hierarchy/anarchy dichotomy to distinguish domestic and international arenas, this seems a radical transformation of the familiar Westphalian system and to undermine state sovereignty. Paradoxically, however, the principle of sovereignty proves to be resilient despite its alleged empirical decline. This article argues that social constructivism can explain the paradox, by considering sovereign statehood as a process-dependent institutional fact, and by showing that multilevel governance can feed into this process