4,880 research outputs found

    The development of Cannabidiol as a psychiatric therapeutic:a review of its antipsychotic efficacy and possible underlying pharmacodynamic mechanisms

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    Cannabidiol (CBD), a once-considered inert cannabis constituent, is one of two primary constituents of cannabis, alongside delta-9-tetrahydrocannabinol (?9-THC/THC). In the last 30 years, CBD has become implicated with a range of pharmaceutical mechanisms of great therapeutic interest and utility. This review details the literature speculating CBD’s attenuation of psychotic symptoms, particularly in light of a marked elevation in mean THC concentrations, and a concomitant decline in CBD concentrations in the prevalent U.K street market cannabis derivatives since c. 2000. CBD is purported to exhibit pharmacology akin to established atypical antipsychotics, whilst THC has been implicated with the precipitation of psychosis, and the induction of associated symptoms. The aim of the review was to clarify the conjecture surrounding CBD’s antipsychotic efficacy, before going on to detail prominent theories about its associated pharmacodynamics. Were CBD’s antipsychotic efficacy established, then there is potential for major latent anthropological repercussions to manifest, such as significant elevations in psychosis manifestations in the U.K. The review found a largely affirmative body of evidence asserting CBD’s antipsychotic efficacy. CBD exhibited capacity to attenuate natural and artificially induced psychoses in both animal and human cohorts, the latter of which included individuals considered resistant to conventional treatment. CBD also shows promising potential for use as an antipsychotic drug for Parkinson’s disease (PD) patients with psychosis, owing to its low rate of extra-pyramidal side-effect induction. A range of potential pharmacological mechanisms behind CBD’s neuroleptic pharmacology are outlined, with particular emphasis on its prevention of the hydrolysis and reuptake of the endogenous cannabinoid, anandamide. However, given the nebular aetiological basis for psychoses, explicit conclusions on how CBD attenuates psychotic symptoms remains to be determined

    Uncorrelated scattering approximation revisited

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    The formalism to describe the scattering of a weakly bound projectile nucleus by a heavy target is investigated, using the Uncorrelated Scattering Approximation. The main assumption involved is to neglect the correlation between the fragments of the projectile in the region where the interaction with the target is important. It is shown that the angular momentum of each fragment with respect to the target is conserved. Moreover, when suitable approximations are assumed, the kinetic energy of each fragment is also shown to be conserved. The S-matrix for the scattering of the composite system can be written as a combination of terms, each one being proportional to the product of the S-matrices of the fragments.Comment: 27 pages, 6 figures, submitted to Nucl. Phys. A (v2: minor misprints and grammatical errors corrected

    Generalized Pearson distributions for charged particles interacting with an electric and/or a magnetic field

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    The linear Boltzmann equation for elastic and/or inelastic scattering is applied to derive the distribution function of a spatially homogeneous system of charged particles spreading in a host medium of two-level atoms and subjected to external electric and/or magnetic fields. We construct a Fokker-Planck approximation to the kinetic equations and derive the most general class of distributions for the given problem by discussing in detail some physically meaningful cases. The equivalence with the transport theory of electrons in a phonon background is also discussed.Comment: 24 pages, version accepted on Physica

    Generalized Complex Spherical Harmonics, Frame Functions, and Gleason Theorem

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    Consider a finite dimensional complex Hilbert space \cH, with dim(\cH) \geq 3, define \bS(\cH):= \{x\in \cH \:|\: ||x||=1\}, and let \nu_\cH be the unique regular Borel positive measure invariant under the action of the unitary operators in \cH, with \nu_\cH(\bS(\cH))=1. We prove that if a complex frame function f : \bS(\cH)\to \bC satisfies f \in \cL^2(\bS(\cH), \nu_\cH), then it verifies Gleason's statement: There is a unique linear operator A: \cH \to \cH such that f(u)=f(u) = for every u \in \bS(\cH). AA is Hermitean when ff is real. No boundedness requirement is thus assumed on ff {\em a priori}.Comment: 9 pages, Accepted for publication in Ann. H. Poincar\'

    Stable Postnikov data of Picard 2-categories

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    Picard 2-categories are symmetric monoidal 2-categories with invertible 0-, 1-, and 2-cells. The classifying space of a Picard 2-category D\mathcal{D} is an infinite loop space, the zeroth space of the KK-theory spectrum KDK\mathcal{D}. This spectrum has stable homotopy groups concentrated in levels 0, 1, and 2. In this paper, we describe part of the Postnikov data of KDK\mathcal{D} in terms of categorical structure. We use this to show that there is no strict skeletal Picard 2-category whose KK-theory realizes the 2-truncation of the sphere spectrum. As part of the proof, we construct a categorical suspension, producing a Picard 2-category ÎŁC\Sigma C from a Picard 1-category CC, and show that it commutes with KK-theory in that KÎŁCK\Sigma C is stably equivalent to ÎŁKC\Sigma K C

    PCV51 THE VALUE OF ATORVASTATIN OVER THE PRODUCT LIFE CYCLE

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