889 research outputs found
Raised cortisol excretion rate in urine and contamination by topical steroids
No abstract available
Divided Differences & Restriction Operator on Paley-Wiener Spaces for Carleson Sequences
For a sequence of complex numbers we consider the restriction
operator defined on Paley-Wiener spaces
(). Lyubarskii and Seip gave necessary and sufficient conditions on
for to be an isomorphism between and a
certain weighted space. The Carleson condition appears to be necessary.
We extend their result to Carleson sequences (finite unions of disjoint
Carleson sequences). More precisely, we give necessary and sufficient
conditions for to be an isomorphism between and
an appropriate sequence space involving divided differences
Goodness-of-Fit Tests to study the Gaussianity of the MAXIMA data
Goodness-of-Fit tests, including Smooth ones, are introduced and applied to
detect non-Gaussianity in Cosmic Microwave Background simulations. We study the
power of three different tests: the Shapiro-Francia test (1972), the
uncategorised smooth test developed by Rayner and Best(1990) and the Neyman's
Smooth Goodness-of-fit test for composite hypotheses (Thomas and Pierce 1979).
The Smooth Goodness-of-Fit tests are designed to be sensitive to the presence
of ``smooth'' deviations from a given distribution. We study the power of these
tests based on the discrimination between Gaussian and non-Gaussian
simulations. Non-Gaussian cases are simulated using the Edgeworth expansion and
assuming pixel-to-pixel independence. Results show these tests behave similarly
and are more powerful than tests directly based on cumulants of order 3, 4, 5
and 6. We have applied these tests to the released MAXIMA data. The applied
tests are built to be powerful against detecting deviations from univariate
Gaussianity. The Cholesky matrix corresponding to signal (based on an assumed
cosmological model) plus noise is used to decorrelate the observations previous
to the analysis. Results indicate that the MAXIMA data are compatible with
Gaussianity.Comment: MNRAS, in pres
Challenges of open innovation: the paradox of firm investment in open-source software
Open innovation is a powerful framework encompassing the generation, capture, and employment of intellectual property at the firm level. We identify three fundamental challenges for firms in applying the concept of open innovation: finding creative ways to exploit internal innovation, incorporating external innovation into internal development, and motivating outsiders to supply an ongoing stream of external innovations. This latter challenge involves a paradox, why would firms spend money on R&D efforts if the results of these efforts are available to rival firms? To explore these challenges, we examine the activity of firms in opensource software to support their innovation strategies. Firms involved in open-source software often make investments that will be shared with real and potential rivals. We identify four strategies firms employ â pooled R&D/product development, spinouts, selling complements and attracting donated complements â and discuss how they address the three key challenges of open innovation. We conclude with suggestions for how similar strategies may apply in other industries and offer some possible avenues for future research on open innovation
Evolution of supermassive black holes
Supermassive black holes (SMBHs) are nowadays believed to reside in most
local galaxies, and the available data show an empirical correlation between
bulge luminosity - or stellar velocity dispersion - and black hole mass,
suggesting a single mechanism for assembling black holes and forming spheroids
in galaxy halos. The evidence is therefore in favour of a co-evolution between
galaxies, black holes and quasars. In cold dark matter cosmogonies, small-mass
subgalactic systems form first to merge later into larger and larger
structures. In this paradigm galaxy halos experience multiple mergers during
their lifetime. If every galaxy with a bulge hosts a SMBH in its center, and a
local galaxy has been made up by multiple mergers, then a black hole binary is
a natural evolutionary stage. The evolution of the supermassive black hole
population clearly has to be investigated taking into account both the
cosmological framework and the dynamical evolution of SMBHs and their hosts.
The seeds of SMBHs have to be looked for in the early Universe, as very
luminous quasars are detected up to redshift higher than z=6. These black holes
evolve then in a hierarchical fashion, following the merger hierarchy of their
host halos. Accretion of gas, traced by quasar activity, plays a fundamental
role in determining the two parameters defining a black hole: mass and spin. A
particularly intriguing epoch is the initial phase of SMBH growth. It is very
challenging to meet the observational constraints at z=6 if BHs are not fed at
very high rates in their infancy.Comment: Extended version of the invited paper to appear in the Proceedings of
the Conference "Relativistic Astrophysics and Cosmology - Einstein's Legacy
Renormalization Group and Decoupling in Curved Space: II. The Standard Model and Beyond
We continue the study of the renormalization group and decoupling of massive
fields in curved space, started in the previous article and analyse the higher
derivative sector of the vacuum metric-dependent action of the Standard Model.
The QCD sector at low-energies is described in terms of the composite effective
fields. For fermions and scalars the massless limit shows perfect
correspondence with the conformal anomaly, but similar limit in a massive
vector case requires an extra compensating scalar. In all three cases the
decoupling goes smoothly and monotonic. A particularly interesting case is the
renormalization group flow in the theory with broken supersymmetry, where the
sign of one of the beta-functions changes on the way from the UV to IR.Comment: 27 pages, 8 figure
Hubble expansion and structure formation in the "running FLRW model" of the cosmic evolution
A new class of FLRW cosmological models with time-evolving fundamental
parameters should emerge naturally from a description of the expansion of the
universe based on the first principles of quantum field theory and string
theory. Within this general paradigm, one expects that both the gravitational
Newton's coupling, G, and the cosmological term, Lambda, should not be strictly
constant but appear rather as smooth functions of the Hubble rate. This
scenario ("running FLRW model") predicts, in a natural way, the existence of
dynamical dark energy without invoking the participation of extraneous scalar
fields. In this paper, we perform a detailed study of these models in the light
of the latest cosmological data, which serves to illustrate the
phenomenological viability of the new dark energy paradigm as a serious
alternative to the traditional scalar field approaches. By performing a joint
likelihood analysis of the recent SNIa data, the CMB shift parameter, and the
BAOs traced by the Sloan Digital Sky Survey, we put tight constraints on the
main cosmological parameters. Furthermore, we derive the theoretically
predicted dark-matter halo mass function and the corresponding redshift
distribution of cluster-size halos for the "running" models studied. Despite
the fact that these models closely reproduce the standard LCDM Hubble
expansion, their normalization of the perturbation's power-spectrum varies,
imposing, in many cases, a significantly different cluster-size halo redshift
distribution. This fact indicates that it should be relatively easy to
distinguish between the "running" models and the LCDM cosmology using realistic
future X-ray and Sunyaev-Zeldovich cluster surveys.Comment: Version published in JCAP 08 (2011) 007: 1+41 pages, 6 Figures, 1
Table. Typos corrected. Extended discussion on the computation of the
linearly extrapolated density threshold above which structures collapse in
time-varying vacuum models. One appendix, a few references and one figure
adde
Can serial cerebral MRIs predict the neuronopathic phenotype of MPS II?
OBJECTIVE: To advance the prediction of the neurocognitive development in MPS II patients by jointly analyzing MRI and neurocognitive data in mucopolysaccharidosis (MPS) II patients. METHODS: Cognitive ability scores (CAS) were obtained by neuropsychological testing. Cerebral MRIs were quantified using a diseaseâspecific protocol. MRI sumscores were calculated for atrophy, whiteâmatter abnormalities (WMA) and VirchowâRobin spaces (VRS). To distinguish between atrophy and hydrocephalus the Evans' index and the callosal angle (CA) were measured. A random effects repeated measurement model was used to correlate CAS with the three MRI sumscores. RESULTS: MRI (n = 47) and CAS scores (n = 78) of 19 male patients were analyzed. Ten patients were classified as neuronopathic and nine as nonâneuronopathic. Neuronopathic patients had normal cognitive development until age 3âyears. Mental age plateaued between ages 3 and 6, and subsequently declined with loss of skills at a maximum developmental age of 4âyears. MRIs of neuronopathic patients showed abnormal atrophy sumscores before CAS dropped below the threshold for intellectual disability (<70). Whiteâmatter abnormalities (WMA) and brain atrophy progressed. The calculated sumscores were inversely correlated with CAS (r = â.90 for atrophy and â.69 for WMA). This was not biased by the influence of hydrocephalus as shown by measurement of the Evans' and callosal angle. Changes over time in the VirchowâRobin spaces (VRS) on MRI were minimal. CONCLUSION: In our cohort, brain atrophy showed a stronger correlation to a decline in CAS when compared to WMA. Atrophyâscores were higher in young neuronopathic patients than in nonâneuronopathic patients and atrophy was an important early sign for the development of the neuronopathic phenotype, especially when observed jointly with whiteâmatter abnormalities
Jet disc coupling in black hole binaries
In the last decade multi-wavelength observations have demonstrated the
importance of jets in the energy output of accreting black hole binaries. The
observed correlations between the presence of a jet and the state of the
accretion flow provide important information on the coupling between accretion
and ejection processes. After a brief review of the properties of black hole
binaries, I illustrate the connection between accretion and ejection through
two particularly interesting examples. First, an INTEGRAL observation of Cygnus
X-1 during a 'mini-' state transition reveals disc jet coupling on time scales
of orders of hours. Second, the black hole XTEJ1118+480 shows complex
correlations between the X-ray and optical emission. Those correlations are
interpreted in terms of coupling between disc and jet on time scales of seconds
or less. Those observations are discussed in the framework of current models.Comment: Invited talk at the Fifth Stromlo Symposium: Disks, Winds & Jets -
from Planets to Quasars. Accepted for publication in Astrophysics & Space
Scienc
Beta cell death by cell-free DNA and outcome after clinical islet transplantation
Background: Optimizing engraftment and early survival after clinical islet transplantation is critical to long-term function, but there are no reliable, quantifiable measures to assess beta cell death. Circulating cell free DNA (cfDNA) derived from beta cells has been identified as a novel biomarker to detect cell loss, and was recently validated in new-onset type 1 diabetes and in islet transplant patients.
Methods: Herein we report beta cell cfDNA measurements after allotransplantation in 37 subjects and the correlation with clinical outcomes.
Results: A distinctive peak of cfDNA was observed 1hr after transplantation in 31/37 (83.8%) of subjects. The presence and magnitude of this signal did not correlate with transplant outcome. The 1hr signal represents dead beta cells carried over into the recipient after islet isolation and culture, combined with acute cell death post infusion. Beta cell cfDNA was also detected 24hrs post-transplant (8/37 subjects, 21.6%). This signal was associated with higher 1-month insulin requirements (p=0.04), lower 1-month stimulated C-peptide levels (p=0.01) and overall worse 3-month engraftment, by insulin independence (ROC:AUC=0.70, p=0.03) and Beta 2 score (ROC:AUC=0.77, p=0.006).
Conclusions: cfDNA-based estimation of beta cell death 24hrs after islet allotransplantation correlates with clinical outcome and could predict early engraftment.B.G.-L. is supported through the Alberta Innovates :Health Solutions (AIHS) Clinician Fellowship and through the CNTRP. A.P. is supported through AIHS Postgraduate Fellowship and CNTRP. A.M.J.S. is supported through AIHS, and holds a Canada Research Chair in Transplantation Surgery and Regenerative Medicine funded through the Government of Canada. A.M.J.S. is also funded by AIHS Collaborative Research and Innovation Opportunity Team Award and the Diabetes Research Institute Foundation of Canada (DRIFCan). Supported by grants from the Juvenile Diabetes Research Foundation (JDRF) (3-SRA-2014-38-Q-R, to Y.D. and A.M.J.S.), National Institute of Health (NIH) (HIRN grant UC4 DK104216, to Y.D.), DON foundation (Stichting Diabetes Onderzoek Nederland) (to Y.D), the European Union (ELASTISLET project, to Y.D.) and the Kahn foundation (to Y.D., R.S., and B.G.). Supported in part by a grant from The United States Agency for International Development (USAID) American Schools and Hospitals Abroad Program for the upgrading of the Hebrew University sequencing core facilit
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