255 research outputs found
Theoretical study of the influence of the morphology in polymer-based devices functioning
It is well known that the morphology of polymer-based optoelectronic devices can influence their efficiency, since the ways that polymer chains pack inside the active layer can influence not only the charge transport but also the optic properties of the device. By using a mesoscopic model we carried out computer experiments to study the influence of the polymer morphology on the processes of charge injection, transport, recombination and collection by the electrodes opposite to those where the injection of bipolar charge carriers take place. Our results show that for polymer layers where the conjugated segments have perpendicular and random orientation relative to the electrodes surface, the competition between charge collection and charge recombination is affected when the average conjugation length of the polymer strands increase. This effect is more pronounced with the increase of the potential barrier at polymer/electrode interfaces that limit charge injection and increase charge collection. For these molecular arrangements the intra-molecular charge transport plays a major role in device performance, being this effect negligible when the polymer molecules have their axis parallel to the electrodes. Although the polymer morphology modelled in this work is far from real, we believe that our model can give some insights on the role of the microstructure on the functioning of polymer-based devices.European Community Fund (FEDER)Fundação para a Ciência e a Tecnologia (FCT) – Programa Operacional “Ciência , Tecnologia, Inovação” – POCTI/CTM/41574/2001, CONC-REEQ/443/EEI/2005 e SFRH/BD/22143/200
Ferroelectric Phase Transitions in Films with Depletion Charge
We consider ferroelectric phase transitions in both short-circuited and
biased ferroelectric-semiconductor films with a space (depletion) charge which
leads to some unusual behavior. It is shown that in the presence of the charge
the polarization separates into `switchable' and `non-switchable' parts. The
electric field, appearing due to the space charge, does not wash out the phase
transition, which remains second order but takes place at somewhat reduced
temperature. At the same time, it leads to a suppression of the
ferroelectricity in a near-electrode layer. This conclusion is valid for
materials with both second and first order phase transitions in pure bulk
samples. Influence of the depletion charge on thermodynamic coercive field
reduces mainly to the lowering of the phase transition temperature, and its
effect is negligible. The depletion charge can, however, facilitate an
appearance of the domain structure which would be detrimental for device
performance (fatigue). We discuss some issues of conceptual character, which
are generally known but were overlooked in previous works. The present results
have general implications for small systems with depletion charge.Comment: 11 pages, REVTeX 3.1, five eps-figures included in the text. Minor
clarifications in the text. To appear in Phys. Rev. B 61, Apr 1 (2000
The Turkish version of the SPPIC validated among informal caregivers with a Turkish immigrant background
Transport spectroscopy in a time-modulated open quantum dot
We have investigated the time-modulated coherent quantum transport phenomena
in a ballistic open quantum dot. The conductance and the electron dwell
time in the dots are calculated by a time-dependent mode-matching method. Under
high-frequency modulation, the traversing electrons are found to exhibit three
types of resonant scatterings. They are intersideband scatterings: into
quasibound states in the dots, into true bound states in the dots, and into
quasibound states just beneath the subband threshold in the leads. Dip
structures or fano structures in are their signatures. Our results show
structures due to 2 intersideband processes. At the above
scattering resonances, we have estimated, according to our dwell time
calculation, the number of round-trip scatterings that the traversing electrons
undertake between the two dot openings.Comment: 8 pages, 5 figure
Cystathionine beta synthase deficiency and brain edema associated with methionine excess under betaine supplementation: Four new cases and a review of the evidence
CBS deficient individuals undergoing betaine supplementation without sufficient dietary methionine restriction can develop severe hypermethioninemia and brain edema. Brain edema has also been observed in individuals with severe hypermethioninemia without concomitant betaine supplementation. We systematically evaluated reports from 11 published and 4 unpublished patients with CBS deficiency and from additional four cases of encephalopathy in association with elevated methionine. We conclude that, while betaine supplementation does greatly exacerbate methionine accumulation, the primary agent causing brain edema is methionine rather than betain
Standardized, Modular Parallelization Platform for Microfluidic Large-Scale Integration Cell Culturing Chips
Standardized high-throughput devices for microfluidic cell cultures are necessary to translate discoveries made in academia to applications in pharmaceutical industry. Here we present a platform with integrated pneumatic valves for standardized parallelization of multichamber chips (SPARC). In total, 192 chambers divided over three microfluidic building blocks (MFBBs) can be filled and purged with spatial and temporal independence. The dimensions of both the MFBB and the platform are standardized and thus compatible with common lab equipment. We characterize the valves at different pumping and gate pressures and show that the MFBBs are suitable for culturing human umbilical vein endothelial cells (HUVECs)
Adherence to the WHO's Healthy Diet Indicator and Overall Cancer Risk in the EPIC-NL Cohort
Background: A healthy dietary pattern defined by international recommendations of the World Health Organisation (WHO) has been shown to reduce overall mortality risk. It is unknown whether this healthy dietary pattern is associated with overall cancer incidence. Design: In total 35,355 men and women within the Dutch European Prospective Investigation into Cancer and Nutrition-cohort were followed for cancer occurrence. Diet was assessed through a validated food-frequency questionnaire. We computed a dietary score for all participants based on the seven WHO dietary guidelines for the prevention of chronic diseases (Healthy Diet Indicator (HDI)). We used the existing HDI score based on the 1990 WHO guidelines, and adapted it to meet with the 2002 WHO guidelines. Multivariate-adjusted Cox proportional hazards analysis was used to examine the association between adherence to the HDI and subsequent overall cancer risk. Results: A number of 3,007 new cancers were identified during a mean follow-up of 12.7 years. Adherence to the HDI was not associated with a reduced overall cancer risk. The hazard ratio (HR) of overall cancer associated with a one-point increment of the HDI was 0.96 (95% CI 0.89-1.03) in men, and 1.00 (95% CI 0.96-1.04) in women. Adherence to the HDI was not associated with smoking-related cancer ((HR men: 0.94 (95% CI 0.84-1.04); HR women: 1.00 (95% CI 0.94-1.07)), or alcohol-related cancer ((HR men: 1.02 (95% CI 0.87-1.20); HR women: 1.03 (95% CI 0.98-1.08)). Conclusions: Greater adherence to the WHO's Healthy Diet Indicator, a dietary pattern for prevention of chronic diseases, was not associated with reduced overall, smoking-related or alcohol-related cancer risk in men or women
Pelvic floor dysfunction is not a risk factor for febrile urinary tract infection in adults
OBJECTIVE To determine whether pelvic floor dysfunction (PFD) might be a risk factor for or consequence of febrile urinary tract infection (UTI), as UTI in adults is a common infection in which an underlying urological abnormality is often considered, and as in children, PFD is also thought to have a pathophysiological role in adults with UTI. PATIENTS AND METHODS A multicentre case-control study was conducted at 26 primary-care centres and at six Emergency Departments of regional hospitals. Cases were consecutive patients aged >= 18 years, who presented with febrile UTI. Controls were randomly selected subjects who visited their general practitioner for reasons other than UTI or fever. A validated pelvic floor questionnaire (the Pelvic Floor Inventories Leiden, PelFIs) was used to assess pelvic floor function. RESULTS Between October 2006 and December 2007, 153 cases were included; of these, the completed questionnaires of 102 (response rate 67%) were compared to those of 100 of 110 (response rate 91%) controls. The median age of cases and controls was 65 and 58 years, respectively; 40% of cases and controls were men. The percentage of PelFIs outcomes consistent with PFD were comparable between cases and controls, at 21% vs 23%, respectively (odds ratio 0.9, 95% confidence interval, CI, 0.4-1.78). In the multivariate analysis, comorbidity (odds ratio 4.9, 95% CI 2.2-11.1) and a history of UTI (odds ratio 2.5, 95% CI 1.0-6.1) were independent significant risk factors for febrile UTI, whereas PFD was not (odds ratio 1.0, 0.5-2.2). Within the group of cases, PFD was not associated with bacteriuria during assessment of PelFIs (odds ratio 1.1, 95% CI 0.4-3.5) and inversely related to a history of UTI within the previous year (odds ratio 0.2, 0.1-0.9). CONCLUSIONS PFD is common among adults but it does not seem to be a risk factor for febrile UTI.Immunogenetics and cellular immunology of bacterial infectious disease
A search for periodicity in the light curves of selected blazars
We present an analysis of multifrequency light curves of the sources 2223-052
(3C 446), 2230+114 (CTA 102), and 2251+158 (3C 454.3), which had shown evidence
of quasi-periodic activity. The analysis made use of data from the University
of Michican Radio Astronomy Observatory (USA) at 4.8, 8, and 14.5 GHz, as well
as the Metsahovi Radio Astronomy Observatory (Finland) at 22 and 37 GHz.
Application of two different methods (the discrete autocorrelation function and
the method of Jurkevich) both revealed evidence for periodicity in the flux
variations of these sources at essentially all frequencies. The periods derived
for at least two of the sources -- 2223-052 and 2251+158-- are in good
agreement with the time interval between the appearance of successive VLBI
components. The derived periods for 2251+158 (P = 12.4 yr and 2223-052 (P = 5.8
yr) coincide with the periods found earlier by other authors based on optical
light curves.Comment: 27 pages, 11 figures, accepted for publication in Astronomy Report
Euler-Calogero-Moser system from SU(2) Yang-Mills theory
The relation between SU(2) Yang-Mills mechanics, originated from the
4-dimensional SU(2) Yang-Mills theory under the supposition of spatial
homogeneity of the gauge fields, and the Euler-Calogero-Moser model is
discussed in the framework of Hamiltonian reduction. Two kinds of reductions of
the degrees of freedom are considered: due to the gauge invariance and due to
the discrete symmetry. In the former case, it is shown that after elimination
of the gauge degrees of freedom from the SU(2) Yang-Mills mechanics the
resulting unconstrained system represents the ID_3 Euler-Calogero-Moser model
with an external fourth-order potential. Whereas in the latter, the IA_6
Euler-Calogero-Moser model embedded in an external potential is derived whose
projection onto the invariant submanifold through the discrete symmetry
coincides again with the SU(2) Yang-Mills mechanics. Based on this connection,
the equations of motion of the SU(2) Yang-Mills mechanics in the limit of the
zero coupling constant are presented in the Lax form.Comment: Revtex, 14 pages, no figures. Abstract changed, strata analysis have
been included, typos corrected, references adde
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