Author Correction: The genetic legacy of continental scale admixture in Indian Austroasiatic speakers

This Article contains errors in the Methods section, under subsection ‘Samples collection and genotyping’

Offshore Frontal Part of the Makran Accretionary Prism: The Chamak Survey (Pakistan)

The Makran accretionary prism developed in the north-western part of the Indian Ocean as a consequence of the subduction of the Arabian Sea since Late Cretaceous times. It extends from southern Iran to the Baluchistan region of Pakistan where it joins the Chaman-Ornach-Nal left-lateral strike-slip fault systems to the north and the Owen Fracture Zone-Murray Ridge transtensional (right-lateral) system to the south in a complex triple junction near the city of Karachi. In September to October of 2004, we surveyed most of the accretionary complex off Pakistan with R/V Marion Dufresne. We achieved a nearly continuous bathymetric mapping of the prism and the subduction trench from 62°30′E to the triple junction near 62°30′E together with nearly 1000 km of seismic reflection (13 lines) and we took 18 piston cores in different geological settings. One of the main results is that the frontal part of the Makran accretionary prism is less two-dimensional than previously expected. We interpret the along-strike tectonic variation as a consequence of lateral variations in sediment deposition as well as a consequence of the under-thrusting of a series of basement highs and finally of the vicinity to the triple junction

Origin and spread of human mitochondrial DNA haplogroup U7

Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (∼16-19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia. Here we report 267 new U7 mitogenomes that - analysed alongside 100 published ones - enable us to discern at least two distinct temporal phases of dispersal, both of which most likely emanated from the Near East. The earlier one began prior to the Holocene (∼11.5 thousand years ago) towards South Asia, while the later dispersal took place more recently towards Mediterranean Europe during the Neolithic (∼8 thousand years ago). These findings imply that the carriers of haplogroup U7 spread to South Asia and Europe before the suggested Bronze Age expansion of Indo-European languages from the Pontic-Caspian Steppe region. © The Author(s) 2017

Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC EORP PPCM Registry

Aims: Hypertensive disorders occur in women with peripartum cardiomyopathy (PPCM). How often hypertensive disorders co-exist, and to what extent they impact outcomes, is less clear. We describe differences in phenotype and outcomes in women with PPCM with and without hypertensive disorders during pregnancy. Methods: The European Society of Cardiology PPCM Registry enrolled women with PPCM from 2012-2018. Three groups were examined: 1) women without hypertension (‘PPCM-noHTN’); 2) women with hypertension but without pre-eclampsia (‘PPCM-HTN’); 3) women with pre-eclampsia (‘PPCM-PE’). Maternal (6-month) and neonatal outcomes were compared. Results: Of 735 women included, 452 (61.5%) had PPCM-noHTN, 99 (13.5%) had PPCM-HTN and 184 (25.0%) had PPCM-PE. Compared to women with PPCM-noHTN, women with PPCM-PE had more severe symptoms (NYHA IV in 44.4% and 29.9%, p<0.001), more frequent signs of heart failure (pulmonary rales in 70.7% and 55.4%, p=0.002), higher baseline LVEF (32.7% and 30.7%, p=0.005) and smaller left ventricular end diastolic diameter (57.4mm [±6.7] and 59.8mm [±8.1], p<0.001). There were no differences in the frequencies of death from any cause, re-hospitalization for any cause, stroke, or thromboembolic events. Compared to women with PPCM-noHTN, women with PPCM-PE had a greater likelihood of left ventricular recovery (LVEF≥50%) (adjusted OR 2.08 95% CI 1.21-3.57) and an adverse neonatal outcome (composite of termination, miscarriage, low birth weight or neonatal death) (adjusted OR 2.84 95% CI 1.66-4.87). Conclusion: Differences exist in phenotype, recovery of cardiac function and neonatal outcomes according to hypertensive status in women with PPCM