11 research outputs found
The use of pasture reflectance characteristics and arbuscular mycorrhizal root colonization to predict pasture characteristics of tallgrass prairie grazed by cattle and bison
Fire effects on mycorrhizal symbiosis and root system architecture in southern African savanna grasses
Hepatitis B virus reactivation in B-cell lymphoma patients treated with rituximab: Analysis from the Asia Lymphoma Study Group
10.1016/j.ejca.2013.07.006European Journal of Cancer49163486-3496EJCA
Communities of arbuscular mycorrhizal fungi in grassland: Seasonal variability and effects of environment and host plants
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before. We report thumb and spine osteoarthritis risk variants and identify differences in genetic effects between weight-bearing and non-weight-bearing joints. We identify sex-specific and early age-at-onset osteoarthritis risk loci. We integrate functional genomics data from primary patient tissues (including articular cartilage, subchondral bone, and osteophytic cartilage) and identify high-confidence effector genes. We provide evidence for genetic correlation with phenotypes related to pain, the main disease symptom, and identify likely causal genes linked to neuronal processes. Our results provide insights into key molecular players in disease processes and highlight attractive drug targets to accelerate translation. © 2021 The Author