Role of healthy-looking banana and alternate hosts in the spread of banana bunchy top disease

Poster presented at Symposium of the Pest Management Council of the Philippines. 200

H^+ -> W^+ l_i^- l_j^+$ decay in the two Higgs doublet model

We study the lepton flavor violating H^+ -> W^+ l_i^- l_j^+ and the lepton flavor conserving $H^+ -> W^+ l_i^- l_i^+ (l_i=\tau, l_j=\mu) decays in the general 2HDM, so called model III. We estimate the decay width \Gamma for LFV (LFC) at the order of the magnitude of (10^{-11}-10^{-5}) GeV ((10^{-9}-10^{-4}) GeV), for 200 GeV\leq m_{H^\pm}\leq 400 GeV, and the intermediate values of the coupling \bar{\xi}^{E}_{N,\tau \mu}\sim 5 GeV (\bar{\xi}^{E}_{N,\tau \tau}\sim 30 GeV). We observe that the experimental result of the process under consideration can give comprehensive information about the physics beyond the standard model and the existing free parameters.Comment: 8 pages, 7 Figure

Slow relaxations and history dependence of the transport properties of layered superconductors

We study numerically the time evolution of the transport properties of layered superconductors after different preparations. We show that, in accordance with recent experiments in BSCCO performed in the second peak region of the phase diagram (Portier et al, 2001), the relaxation strongly depends on the initial conditions and is extremely slow. We investigate the dependence on the pinning center density and the perturbation applied. We compare the measurements to recent findings in tapped granular matter and we interpret our results with a rather simple picture.Comment: 4 pages, 4 fig

Prospects for Discovering Supersymmetry at the LHC

Supersymmetry is one of the best-motivated candidates for physics beyond the Standard Model that might be discovered at the LHC. There are many reasons to expect that it may appear at the TeV scale, in particular because it provides a natural cold dark matter candidate. The apparent discrepancy between the experimental measurement of g_mu - 2 and the Standard model value calculated using low-energy e+ e- data favours relatively light sparticles accessible to the LHC. A global likelihood analysis including this, other electroweak precision observables and B-decay observables suggests that the LHC might be able to discover supersymmetry with 1/fb or less of integrated luminosity. The LHC should be able to discover supersymmetry via the classic missing-energy signature, or in alternative phenomenological scenarios. The prospects for discovering supersymmetry at the LHC look very good.Comment: 8 pages, 11 figure

M1 Resonances in Unstable Magic Nuclei

Within a microscopic approach which takes into account RPA configurations, the single-particle continuum and more complex $1p1h\otimes phonon$ configurations isoscalar and isovector M1 excitations for the unstable nuclei ${56,78}$Ni and ${100,132}$Sn are calculated. For comparison, the experimentally known M1 excitations in ${40}$Ca and $^{208}$Pb have also been calculated. In the latter nuclei good agreement in the centroid energy, the total transition strength and the resonance width is obtained. With the same parameters we predict the magnetic excitations for the unstable nuclei. The strength is sufficiently concentrated to be measurable in radioactive beam experiments. New features are found for the very neutron rich nucleus ${78}$Ni and the neutron deficient nucleus ${100}$Sn.Comment: 17 pages (LATEX), 12 figures (available from the authors), KFA-IKP(TH)-1993-0

Zinc-phthalocyanine-loaded extracellular vesicles increase efficacy and selectivity of photodynamic therapy in co-culture and preclinical models of colon cancer

Photodynamic therapy (PDT) is a promising and clinically approved method for the treatment of cancer. However, the efficacy of PDT is often limited by the poor selectivity and distribution of the photosensitizers (PS) toward the malignant tumors, resulting in prolonged periods of skin photosensitivity. In this work, we present a simple and straightforward strategy to increase the tumor distribution, selectivity, and efficacy of lipophilic PS zinc phthalocyanine (ZnPc) in colon cancer by their stabilization in purified, naturally secreted extracellular vesicles (EVs). The PS ZnPc was incorporated in EVs (EV-ZnPc) by a direct incubation strategy that did not affect size distribution or surface charge. By using co-culture models simulating a tumor microenvironment, we determined the preferential uptake of EV-ZnPc toward colon cancer cells when compared with macrophages and dendritic cells. We observed that PDT promoted total tumor cell death in normal and immune cells, but showed selectivity against cancer cells in co-culture models. In vivo assays showed that after a single intravenous or intratumoral injection, EV-ZnPc were able to target the tumor cells and strongly reduce tumor growth over 15 days. These data expose opportunities to enhance the potential and efficacy of PDT using simple non-synthetic strategies that might facilitate translation into clinical practice.Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Ceramide and palmitic acid inhibit macrophage-mediated epithelial-mesenchymal transition in colorectal cancer

Accumulating evidence indicates that ceramide (Cer) and palmitic acid (PA) possess the ability to modulate switching of macrophage phenotypes and possess anti-tumorigenic effects; however, the underlying molecular mechanisms are largely unknown. The aim of the present study was to investigate whether Cer and PA could induce switching of macrophage polarization from the tumorigenic M2- towards the pro-inflammatory M1-phenotype, and whether this consequently altered the potential of colorectal cancer cells to undergo epithelial-mesenchymal transition (EMT), a hallmark of tumor progression. Our study showed that Cer- and PA-treated macrophages increased expression of the macrophage 1 (M1)-marker CD68 and secretion of IL-12 and attenuated expression of the macrophage 2 (M2)-marker CD163 and IL-10 secretion. Moreover, Cer and PA abolished M2 macrophage-induced EMT and migration of colorectal cancer cells. At the molecular level, this coincided with inhibition of SNAI1 and vimentin expression and upregulation of E-cadherin. Furthermore, Cer and PA attenuated expression levels of IL-10 in colorectal cancer cells co-cultured with M2 macrophages and downregulated STAT3 and NF-kappa B expression. For the first time, our findings suggest the presence of an IL-10-STAT3-NF-kappa B signaling axis in colorectal cancer cells co-cultured with M2 macrophages, mimicking the tumor microenvironment. Importantly, PA and Cer were powerful inhibitors of this signaling axis and, consequently, EMT of colorectal cancer cells. These results contribute to our understanding of the immunological mechanisms that underlie the anti-tumorigenic effects of lipids for future combination with drugs in the therapy of colorectal carcinoma.Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Ceramide and palmitic acid inhibit macrophage-mediated epithelial-mesenchymal transition in colorectal cancer (vol 468, pg 153, 2020)

Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Optoelectrical analysis of TCO Silicon oxide double layers at the front and rear side of silicon heterojunction solar cells

Silicon Heterojunction has become a promising technology to substitute passivated emitter and rear contact PERC solar cells in pursuance of lower levelized cost of electricity through high efficiency devices. While high open circuit voltages and fill factors are reached, current loss related to the front and rear contacts, such as the transparent conductive oxide TCO layers is still a limiting factor to come closer to the efficiency limit of silicon based solar cells. Furthermore, reducing indium consumption for the TCO has become mandatory to push silicon heterojunction technology towards a terawatt scale production due to material scarcity and costs. To address these issues dielectric layers, such as silicon dioxide or nitride cappings are implemented to reduce TCO thicknesses both diminishing parasitic absorption and material consumption. However, reducing the TCO thickness comes in cost of resistive losses. Furthermore, the TCO properties do vary with thickness and neighboring layer configuration altering the optimization frame of the device. In this paper we present a detailed analysis to quantify the optoelectrical losses trade off associated to the TCO thickness reduction in such layer stacks. Through the analysis we show and explain why experimental bifacial cells with 20 nm front and rear TCO perform at a similar level to reference cells with 75 nm under front and rear illumination reaching efficiency close to 24 at 92 bifaciality. We present as well a simple interconnection method via screen printing metallization to implement a thin TCO silicon dioxide silver reflector enhancing current density from 39.6 to 40.4 mA cm2 without compromising resistive losses resulting in a 0.2 absolute solar cell efficiency increase from a bifacial design 23.5 23.7 . Finally, following this approach we present a certified champion cell with an efficiency of 24.

Inhibiting efferocytosis reverses macrophage-mediated immunosuppression in the leukemia microenvironment

Background: Previous studies show that the spleen and bone marrow can serve as leukemia microenvironments in which macrophages play a significant role in immune evasion and chemoresistance. We hypothesized that the macrophage driven tolerogenic process of efferocytosis is a major contributor to the immunosuppressive leukemia microenvironment and that this was driven by aberrant phosphatidylserine expression from cell turnover and cell membrane dysregulation. Methods: Since MerTK is the prototypic efferocytosis receptor, we assessed whether the MerTK inhibitor MRX2843, which is currently in clinical trials, would reverse immune evasion and enhance immune-mediated clearance of leukemia cells. Results: We found that inhibition of MerTK decreased leukemia-associated macrophage expression of M2 markers PD-L1, PD-L2, Tim-3, CD163 and Arginase-1 compared to vehicle-treated controls. Additionally, MerTK inhibition led to M1 macrophage repolarization including elevated CD86 and HLA-DR expression, and increased production of T cell activating cytokines, including IFN-β, IL-18, and IL-1β through activation of NF-κB. Collectively, this macrophage repolarization had downstream effects on T cells within the leukemia microenvironment, including decreased PD-1+Tim-3+ and LAG3+ checkpoint expression, and increased CD69+CD107a+ expression. Discussion: These results demonstrate that MerTK inhibition using MRX2843 altered the leukemia microenvironment from tumor-permissive toward immune responsiveness to leukemia and culminated in improved immune-mediated clearance of AML