Time course and robustness of ERP object and face differences

Conflicting results have been reported about the earliest “true” ERP differences related to face processing, with the bulk of the literature focusing on the signal in the first 200 ms after stimulus onset. Part of the discrepancy might be explained by uncontrolled low-level differences between images used to assess the timing of face processing. In the present experiment, we used a set of faces, houses, and noise textures with identical amplitude spectra to equate energy in each spatial frequency band. The timing of face processing was evaluated using face–house and face–noise contrasts, as well as upright-inverted stimulus contrasts. ERP differences were evaluated systematically at all electrodes, across subjects, and in each subject individually, using trimmed means and bootstrap tests. Different strategies were employed to assess the robustness of ERP differential activities in individual subjects and group comparisons. We report results showing that the most conspicuous and reliable effects were systematically observed in the N170 latency range, starting at about 130–150 ms after stimulus onset

Rapid prototyping of flexible models - a new methods for model testing?

To date hydroelastic towing tank models are generally segmented, flexible backbone or hinged models which provide an extremely limited representation of the ship structure and record loads only at a finite number of locations between segments. Fully flexible “hydro-structural” models, whilst providing a more accurate structural representation are rarely used due to expense and the complicated nature of their construction. Rapid prototyping is a powerful tool the potential of which is yet to be exploited in the marine industry. By using it to manufacture a realistic ship structure from materials of different properties, new model manufacturing paradigms may be explored. The focus of this paper is the initial findings from an investigation of the use of three-dimensional (3D) printing technologies for manufacturing structurally accurate flexible towing tank models. A detailed assessment is carried out of the material properties of 3D printed materials and their ability to model the scaled structural behaviour of a ship. Scaling implications when considering the realistic ship structure are presented and practical considerations for the construction of 3D printed towing tank models are discussed

Experimental investigation of the influence of floodwater due to ship grounding on motions and global loads

High profile collision and grounding incidents show that safety standards for ships need improvement to ensure ship survivability and reduce the potential for loss of life. An experimental investigation into the influence of floodwater, and transient flooding on the motions and structural response of a ship hull following a grounding incident is presented. Results show that floodwater can have a significant effect on the magnitude of ship responses; testing of the transient flooding case provides the opportunity to quantify the magnitude of these changes as well as the time to flood by provision of intact and flooded data during a single test. The movement of the floodwater free surface shows some substantial second order sloshing effects when close to the ship peak response, but little movement in higher frequency waves. Comparisons to classification design rules indicate that there is scope for further assessment of safety margins, including investigation of global responses in conjunction with any local loading due to the presence of floodwater. Future work will look at improving the modelling of the floodwater free surface and carrying out further transient flooding testing in order to better quantify the effect of a ship grounding incident on the survivability of a vessel

Effects of resonant single-particle states on pairing correlations

Effects of resonant single-particle (s.p.) states on the pairing correlations are investigated by an exact treatment of the pairing Hamiltonian on the Gamow shell model basis. We introduce the s.p. states with complex energies into the Richardson equations. The solution shows the property that the resonant s.p. states with large widths are less occupied. The importance of many-body correlations between bound and resonant prticle pairs is shown.Comment: 4 pages, 3 figures, to be published in Phys. Rev.

Effects of nuclear structure on average angular momentum in subbarrier fusion

We investigate the effects of nuclear quadrupole and hexadecapole couplings on the average angular momentum in sub-barrier fusion reactions. This quantity could provide a probe for nuclear shapes, distinguishing between prolate vs. oblate quadrupole and positive vs. negative hexadecapole couplings. We describe the data in the O + Sm system and discuss heavier systems where shape effects become more pronounced.Comment: Latex (uses the epsf macro), 10 pages of text, 3 postscript figures included. Full postscript version available by anonymous ftp from wisnuf.physics.wisc.edu:/pub/preprints. MAD-NT-94-0

Globally Exact Asymptotics for Integrals with Arbitrary Order Saddles

We derive the first exact, rigorous but practical, globally valid remainder terms for asymptotic expansions about saddles and contour endpoints of arbitrary order degeneracy derived from the method of steepest descents. The exact remainder terms lead naturally to sharper novel asymptotic bounds for truncated expansions that are a significant improvement over the previous best existing bounds for quadratic saddles derived two decades ago. We also develop a comprehensive hyperasymptotic theory, whereby the remainder terms are iteratively reexpanded about adjacent saddle points to achieve better-than-exponential accuracy. By necessity of the degeneracy, the form of the hyperasymptotic expansions is more complicated than in the case of quadratic endpoints and saddles and requires generalizations of the hyperterminants derived in those cases. However, we provide efficient methods to evaluate them, and we remove all possible ambiguities in their definition. We illustrate this approach for three different examples, providing all the necessary information for the practical implementation of the method

Microfluidic and Nanofluidic Cavities for Quantum Fluids Experiments

The union of quantum fluids research with nanoscience is rich with opportunities for new physics. The relevant length scales in quantum fluids, 3He in particular, are comparable to those possible using microfluidic and nanofluidic devices. In this article, we will briefly review how the physics of quantum fluids depends strongly on confinement on the microscale and nanoscale. Then we present devices fabricated specifically for quantum fluids research, with cavity sizes ranging from 30 nm to 11 microns deep, and the characterization of these devices for low temperature quantum fluids experiments.Comment: 12 pages, 3 figures, Accepted to Journal of Low Temperature Physic

Communicating Josephson Qubits

We propose a scheme to implement a quantum information transfer protocol with a superconducting circuit and Josephson charge qubits. The information exchange is mediated by an L-C resonator used as a data bus. The main decoherence sources are analyzed in detail.Comment: 4 pages, 2 figure

Prion protein interacts with bace1 and differentially regulates its activity towards wild type and swedish mutant amyloid precursor protein

In Alzheimer disease amyloid-β (Aβ) peptides derived from the amyloid precursor protein (APP) accumulate in the brain. Cleavage of APP by the β-secretase BACE1 is the rate-limiting step in the production of Aβ. We have reported previously that the cellular prion protein (PrP(C)) inhibited the action of BACE1 toward human wild type APP (APP(WT)) in cellular models and that the levels of endogenous murine Aβ were significantly increased in PrP(C)-null mouse brain. Here we investigated the molecular and cellular mechanisms underlying this observation. PrP(C) interacted directly with the prodomain of the immature Golgi-localized form of BACE1. This interaction decreased BACE1 at the cell surface and in endosomes where it preferentially cleaves APP(WT) but increased it in the Golgi where it preferentially cleaves APP with the Swedish mutation (APP(Swe)). In transgenic mice expressing human APP with the Swedish and Indiana familial mutations (APP(Swe,Ind)), PrP(C) deletion had no influence on APP proteolytic processing, Aβ plaque deposition, or levels of soluble Aβ or Aβ oligomers. In cells, although PrP(C) inhibited the action of BACE1 on APP(WT), it did not inhibit BACE1 activity toward APP(Swe). The differential subcellular location of the BACE1 cleavage of APP(Swe) relative to APP(WT) provides an explanation for the failure of PrP(C) deletion to affect Aβ accumulation in APP(Swe,Ind) mice. Thus, although PrP(C) exerts no control on cleavage of APP(Swe) by BACE1, it has a profound influence on the cleavage of APP(WT), suggesting that PrP(C) may be a key protective player against sporadic Alzheimer disease

Racial differences in user experiences and perceived value of electronic symptom monitoring in a cohort of black and white bladder and prostate cancer patients

Purpose: Electronic patient-reported outcomes (ePROs) are increasingly being used for symptom monitoring during routine cancer care, but have rarely been evaluated in diverse patient populations. We assessed ePRO user experiences and perceived value among Black and White cancer patients. Methods: We recruited 30 Black and 49 White bladder and prostate cancer patients from a single institution. Participants reported symptoms using either a web-based or automated telephone interface over 3 months and completed satisfaction surveys and qualitative interviews focused on user experiences and value. Using a narrative mixed methods approach, we evaluated overall and race-specific differences in ePRO user experiences and perceived value. Results: Most participants selected the web-based system, but Blacks were more likely to use the automated telephone-based system than Whites. In satisfaction surveys, Whites more commonly reported ease in understanding and reporting symptoms compared with Blacks. Blacks more often reported that the ePRO system was helpful in facilitating symptom-related discussions with clinicians. During interviews, Blacks described how the ePRO helped them recognize symptoms, while Whites found value in better understanding and tracking symptoms longitudinally. Blacks also expressed preferences for paper-based ePRO options due to perceived ease in better understanding of symptom items. Conclusion: Electronic patient-reported outcomes are perceived as valuable for variable reasons by Black and White cancer populations, with greater perceived value for communicating with clinicians reported among Blacks. To optimize equitable uptake of ePROs, oncology practices should offer several ePRO options (e.g., web-based, phone-based), as well as paper-based options, and consider the e-health literacy needs of patients during implementation