Cooper pair dispersion relation in two dimensions

The Cooper pair binding energy {\it vs.} center-of-mass-momentum dispersion relation for Bose-Einstein condensation studies of superconductivity is found in two dimensions for a renormalized attractive delta interaction. It crosses over smoothly from a linear to a quadratic form as coupling varies from weak to strong.Comment: 2 pages, 1 figure, new version published in Physica

Bose-Einstein condensation of nonzero-center-of-mass-momentum Cooper pairs

Cooper pair (CP) binding with both zero and nonzero center-of-mass momenta (CMM) is studied with a set of renormalized equations assuming a short-ranged (attractive) pairwise interfermion interaction. Expanding the associated dispersion relation in 2D in powers of the CMM, in weak-to-moderate coupling a term {\it linear} in the CMM dominates the pair excitation energy, while the quadratic behavior usually assumed in Bose-Einstein (BE)-condensation studies prevails for any coupling {\it only} in the limit of zero Fermi velocity when the Fermi sea disappears, i.e., in vacuum. In 3D this same behavior is observed numerically. The linear term, moreover, exhibits CP breakup beyond a threshold CMM value which vanishes with coupling. This makes all the excited (nonzero-CMM) BE levels with preformed CPs collapse into a single ground level so that a BCS condensate (where only zero CMM CPs are usually allowed) appears in zero coupling to be a special case in either 2D or 3D of the BE condensate of linear-dispersion-relation CPs.Comment: Four pages including four figures. To be published in Physica

Linear to quadratic crossover of Cooper pair dispersion relation

Cooper pairing is studied in three dimensions to determine its binding energy for all coupling using a general separable interfermion interaction. Also considered are Cooper pairs (CPs) with nonzero center-of-mass momentum (CMM). A coupling-independent {\it linear} term in the CMM dominates the pair excitation energy in weak coupling and/or high fermion density, while the more familiar quadratic term prevails only in the extreme low-density (i.e., vacuum) limit for any nonzero coupling. The linear-to-quadratic crossover of the CP dispersion relation is analyzed numerically, and is expected to play a central role in a model of superconductivity (and superfluidity) simultaneously accommodating a BCS condensate as well as a Bose-Einstein condensate of CP bosons.Comment: 13 pages plus 2 figure

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries