8 research outputs found
In vitro study of valve-in-valve performance with the CoreValve self-expandable prosthesis implanted in different positions and sizes within the Trifecta surgical heart valve
International audienceno abstrac
In vitro study of valve-in-valve performance with the CoreValve self-expandable prosthesis implanted in different positions and sizes within the Trifecta surgical heart valve
Mouse oocyte vitrification: the effects of two methods on maturing germinal vesicle breakdown oocytes
Purpose Evaluation of viability and subsequent developmental
ability of mouse germinal vesicle breakdown
oocytes vitrified in conventional straws.
Methods Oocytes with compact cumulus cells were cultured
for 3 h in TCM199 medium GVBD and vitrified by
two methods: the step-wise and single-step. After vitrification,
the oocytes were thawed, and subjected to in vitro
maturation and in vitro fertilization. Oocyte survival (postthaw)
was assessed by morphological appearance and
staining, using propidium iodide (PI)/Hoechst 33342. The
oocyte maturation and fertilization rates were examined in
vitro.
Results In the single-step method the rates of post thaw
survival, maturation to metaphase II and cleavage (2-cell
embryos) were 58.68%, 56.41% and 38.63%, respectively.
In the step-wise method, the corresponding rates were
81.75%, 68.59% and 51.80%, respectively.
Conclusion Vitrification of mouse germinal vesicle breakdown
oocytes by the step-wise method had the advantag
On the Modeling of Patient-Specific Transcatheter Aortic Valve Replacement: A Fluid–Structure Interaction Approach
On the Mechanics of Transcatheter Aortic Valve Replacement
Transcatheter aortic valves (TAVs) represent the latest advances in prosthetic heart valve technology. TAVs are truly transformational as they bring the benefit of heart valve replacement to patients that would otherwise not be operated on. Nevertheless, like any new device technology, the high expectations are dampened with growing concerns arising from frequent complications that develop in patients, indicating that the technology is far from being mature. Some of the most common complications that plague current TAV devices include malpositioning, crimp-induced leaflet damage, paravalvular leak, thrombosis, conduction abnormalities and prosthesis-patient mismatch. In this article, we provide an in-depth review of the current state-of-the-art pertaining the mechanics of TAVs while highlighting various studies guiding clinicians, regulatory agencies, and next-generation device designers