Estabilidade durante armazenamento de hambúrguer vegetal elaborado à base de caju.

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Prostaglandin E2-EP1 and EP2 receptor signaling promotes apical junctional complex disassembly of Caco-2 human colorectal cancer cells

<p>Abstract</p> <p>Background</p> <p>The apical junctional complex (AJC) is a dynamic structure responsible to maintain epithelial cell-cell adhesions and it plays important functions such as, polarity, mechanical integrity, and cell signaling. Alteration of this complex during pathological events leads to an impaired epithelial barrier by perturbation of the cell-cell adhesion system. Although clinical and experimental data indicate that prostaglandin E₂(PGE₂) plays a critical function in promoting cell motility and cancer progression, little is known concerning its role in AJC disassembly, an event that takes place at the beginning of colorectal tumorigenesis. Using Caco-2 cells, a cell line derived from human colorectal cancer, we investigated the effects of prostaglandin E₂(PGE₂) treatment on AJC assembly and function.</p> <p>Results</p> <p>Exposition of Caco-2 cells to PGE₂promoted differential alteration of AJC protein distribution, as evidenced by immunofluorescence and immunoblotting analysis and impairs the barrier function, as seen by a decrease in the transepithelial electric resistance and an increase in the permeability to ruthenium red marker. We demonstrated the involvement of EP1 and EP2 prostaglandin E₂receptor subtypes in the modulation of the AJC disassembly caused by prostanoid. Furthermore, pharmacological inhibition of protein kinase-C, but not PKA and p38MAPK significantly prevented the PGE₂effects on the AJC disassembly.</p> <p>Conclusion</p> <p>Our findings strongly suggest a central role of Prostaglandin E2-EP1 and EP2 receptor signaling to mediate AJC disassembly through a mechanism that involves PKC and claudin-1 as important target for the TJ-related effects in human colorectal cancer cells (Caco-2).</p

Criminologia e condenação preexistente: sob a ótica da criança e do adolescente

O artigo busca exprimir, nas entrelinhas do estudo interdisciplinar da criminologia, os motivos que levam uma criança ou um adolescente a cometerem atos infracionais. Assim, através do método quantitativo e qualitativo, visa demonstrar o implícito prejulgamento da sociedade e Estado em razão das desigualdades sociais, em torno dos que já cometeram anteriormente condutas delituosas e aqueles que tragicamente ostentam esse título, sem a observância preliminar do caso concreto. Nesse mesmo viés, demonstrar o etiquetamento que há em determinados grupos, onde, em razão da imposição social, se permite condenações preexistentes pautadas em caráter discriminatório, violando, sobremaneira, princípios constitucionais. Abrange, ainda, quais são as atribuições da família e do Estado no quesito formação e desenvolvimento psicossocial da criança e do adolescente e até onde deve-se reconhecer a extensão de sua responsabilidade. Para tanto, observará a evolução nos direitos da infância e juventude, destacando quais são as medidas protetivas e socioeducativas e, se de fato o sistema carcerário (Fundação Casa) alcanç

Low-cost thermal imager for plant phenotyping.

This work uses a Flir Lepton 3 longwave infrared imager integrated with a Raspberry Pi computer to produce thermal images of crops. The longwave infrared sensor can detect the thermal radiation emitted by objects near room temperature and then determine its temperature.Editores: Paulo Sérgio de Paula Herrmann Junior, Paulino Ribeiro Villas Boas

Low-cost thermal field mapping.

This project is originally designed to be used in rice genetic enhancement fields, but it can be used for other purposes, for example, to verify if any part of the tillage has a disease, when comparing the thermal signature of the species with the thermal map.Editores: Paulo Sérgio de Paula Herrmann Junior, Paulino Ribeiro Villas Boas

Solid state electrochromic display based on polymer electrode-polymer electrolyte interface

The electropolymerization of ortho-toluidine and ortho-anisidine gave uniform electroactive polymer films which were analysed by cyclic voltammetry, impedance and uv-vis absorption spectra. These films exhibit a reversible electrochemical response during cyclic voltammetry experiments in aqueous, non-aqueous and polymer electrolytes. Their electrochromic efficiency is high in aqueous and non-aqueous electrolytes but decreases in the polymer electrolyte. A solid state cell having the configuration ITO/TiO2-CeO2/LiN(SO2CF3)2-PEO complex/polymer/ITO, has been assembled. The transmittance variation of this system between the oxidized and reduced state is about 20% at 632.8 nm

Transparent vs Translucent Multi-Band Optical Networking: Capacity and Energy Analyses

Multi-band optical fiber transmission is generally proposed for capacity upgrades in optical transport networks. To comprehensively assess the potential of multi-band transmission, key metrics such as the potential capacity increase, energy consumption, and the number of required interfaces must be evaluated for different transmission scenarios. We consider progressive spectral exploitation, starting from the C-band only and up to C+L+S+U-band transmission, for both transparent and translucent solutions that exploit optical signal regeneration. By considering accurate state-of-the-art physical layer models, we derive a networking performance metric that enables the comparison of different solutions in terms of capacity allocation and energy consumption. For a translucent network design, different regenerator placement algorithms are compared, with the aim of minimizing energy consumption. The proposed network-wide numerical analysis shows that, for spectral occupations exceeding the C+L-band, translucent solutions can significantly increase network capacity, while leading to a similar energy consumption per transmitted bit as in the transparent design case, but they require the deployment of additional line interfaces. Significantly, these results provide evidence that the transparent exploitation of an additional transmission band produces a capacity increment that is at least comparable to that of a translucent solution based on already-in-use bands. Since this is attained at the expense of fewer line interfaces, it is a key finding suggesting that extending the number of bands supported is a cost-effective approach to scaling the capacity of existing fiber infrastructures

Use of thermographic sensors to determine the water status of plants in a controlled environment.

The foliar temperature of plants, relative to ambient temperature, can be used to infer the water status of plants. Both in the field (crops) and in greenhouse, infrared temperature sensors can be used or even thermal cameras to measure leaf temperature without contact with plants. For the case of the greenhouse, Embrapa Rice and Beans created a system, called SITIS (Integrated System of Induced Treatment of Stress). This platform automates the planning and execution of plant irrigation in a greenhouse.Editores: Paulo Sérgio de Paula Herrmann Junior, Paulino Ribeiro Villas Boas