Synthesis of fused heterocyclic systems based on quinozalines and tetrahydroquinolines

Данная работа направлена на разработку эффективного метода микроволнового синтеза конденсированных гетероциклических систем на основе хиназолинов и тетрагидрохинолинов с использованием реакций, протекающих по механизму трет-амино эффекта.The project aims to develop an effective microwave-assisted synthesis of fused heterocyclic systems based on quinozalines and tetrahydroquinolines by using the tert-amino effect.Программа развития УрФУ на 2013 год (п.1.2.2.3

Технология опытного производства тетрагидрохинолина: (3aS*,4R*)-4-циано-1,2,3,3а,4,5-гексагидро-1Н-пирроло[1,2-а]хинолин-4-карботиоамида

Received: 17.07.2016; accepted: 24.29.2016; published: 01.12.2016.Поступило: 17.07.2016; приянято: 24.09.2016; опубликовано: 01.12.2016.The regulations of the pilot production of (3aS*,4R*)-4-cyano-1,2,3,3а,4,5-hexahydro-1Н-pyrrolo[1,2-а]quinoline-4-carbothioamide designed in Ltd. U-Synthesis is presented in the present work. Main steps of the production are considered, the material balance of the process, specification of main production steps and applied equipment are given.В работе представлен разработанный в ООО «У-Синтез» регламент опытного производства (3aS*,4R*)-4-циано-1,2,3,3а,4,5-гексагидро-1Н-пирроло[1,2-а]хинолин-4-карботиоамида. Рассмотрены основные стадии производства, приведены материальный баланс процесса, описание основных стадий производства и применяемого оборудования

International Legal Regulation in the Sphere of Pension Provision for Cis Citizens

The present article analyzes the pension provision for citizens of the CIS integration associations and legal regulation prospects.In the article the fundamental documents on the pension provision regulation for CIS citizens are discussed, including international bilateral treaties of theRussian Federation

Pension Provision of Citizens in the EAEU and the Union State of the Russian Federation and the Republic of Belarus

The present article provides an international legal analysis of pension provision for citizens of subregional integration associations of CIS (the EAEU and the Union State of the Russian Federation and the Republic of Belarus), well as the prospects for legal regulation. The article concerns the legal basis in part of the pension provision regulation of the integration associations’ citizens of the EAEU, the Union State of Russian Federation and the Republic of Belarus, the procedure for implementing pension rights of integration associations’ citizens

International Legal Features of the Constitutional Rights Implementation of the EAEU Member States Citizens in the Field of Pensions

This article considers the pension provision of workers of the Eurasian Economic Union member states based on an analysis of the EAEU legislation and a comparative analysis of the domestic pension legislation of the EAEU member states in order to identify the features of their citizens’ social protection in the event of disability. The article discusses the procedure for organizing pensions provision with the application of an Agreement on Pension Provisions for Workers of the EAEU member states of 20 December 2019

Tert-Amino effect: The Meth-Cohn and Reinhoudt reactions (Review)

The data published over the last 15-20 years on reactions taking place by the tert-amino effect mechanism have been reviewed. © 2013 Springer Science+Business Media New York

Influence of particles on the functional properties of single crystals of high-strength ferromagnetic alloys

Single crystals of the ordered ferromagnetic Co49Ni21Ga30 (at.%) alloy with B2-L10 martensitic transformation and of the disordered iron-based Fe41Ni28Co17Al11.5X2.5 (X=Ta, Ti) (at.%) alloys, which undergo thermoelastic γ-a' martensitic transformations, were studied in terms of the influence of chemical composition, size and volume fraction of the dispersed γ'- phase particles on functional properties – shape memory effect and superelasticity. Single crystals of Co49Ni21Ga30 alloy showed that the precipitation of nanometric γ'-phase particles changes the martensitic transformation characteristic temperature, reduces the value of the shape memory effect and superelasticity, increases thermal and stress hysteresis, and leads to hardening of the high temperature phase, which promotes superelasticity at a wide temperature range and at high temperatures at T>373K compared with the crystals without particles. Single crystals of FeNiCoAlX (X=Ta, Ti) alloys have experimentally demonstrated that the precipitation of ordered γ'-phase particles at a size of d=5-10 nm during aging at T=973 K, 3 h, leads to the occurrence of the shape memory effect and superelasticity

A case of 17-beta-hydroxysteroid dehydrogenase deficiency type 3 in adult endocrinologist practice

17β-Hydroxysteroid dehydrogenase 3 deficiency (17HSD3) is a rare autosomal recessive cause of 46, XY disorders of sex development resulting from HSD17B3 gene mutations, in which conversion of androstenedione to testosterone is impared. The clinical signs of 17HSD3 deficiency depend on the residual activity of the enzyme. The diagnosis of 17HSD3 deficiency is based on reduced testosterone/androstenedione ratio (T/AD < 0.8). Patients are usually assigned at birth and raise as female. If the diagnosis is made before puberty, gonadectomy is recommended, taking into account the risk of masculinization during the puberty and estrogen therapy initiation in this period. If the diagnosis of 17HSD3 deficiency is established during puberty, when virilization manifests, the therapeutic strategy is based on the results of comprehensive psychological testing and gender identity of a patient. In patients with more pronounced masculinization or diagnosis established shortly after birth, who are assigned at birth and raise as male, testosterone therapy is used to achieve a male phenotype. The 17HSD3 deficiency and virilization often result in a change of gender identity during puberty. The article presents a clinical case of 17-βhydroxysteroid dehydrogenase type 3 deficiency with late diagnosis due to parental will. The diagnostic approaches and management of the disease are also described

Entrepreneurship Education as a Subject of Research

On April 5, 2023 a round-table discussion on “Entrepreneurship Education as a Subject of Research” was organized by the Editorial Board of the “Higher Education in Russia” Journal with the Moscow University for Industry and Finance “Synergy” in the framework of the International Scientific Congress “The Role of Business in Society Transformation – 2023”. Entrepreneurship education formation is a focus of interest as for scientists, and for practitioners as well all around the world. During a round-table there were discussed the actual research issues required attention of academic society. Research trends were defined and connected: 1) with values, identity and moral dimension; 2) with mentors’ experience; 3) with students’ experience

First Use of Superpulsed Fibre Thulium Laser-Based Contact Stone Ablation in Common Bile and Main Pancreatic Ducts

Aim. A clinical demonstration of the feasibility of novel superpulsed thulium fibre laser in contact intraductal lithotripsy in patients with choledocholithiasis and pancreatic lithiasis.Key points. We describe two clinically successful ablations of large biliary and pancreatic calculi using a FiberLase U2 superpulse fibre thulium laser appliance (IRE-Polus, Russia) during oral transpapillary cholangiopancreaticoscopy in patients with technically unfeasible conventional minimally invasive treatment for choledocho- and pancreatic lithiasis. A 72-yo patient was urgently admitted with acute mechanical jaundice, cholangitis and a history of endoscopic papillosphincterotomy (EPST) and bilioduodenal stenting with a plastic implant for technically impractical lithotripsy and lithoextraction. An ineffective extracorporeal lithotripsy attempt was followed on day 3 by a second retrograde intervention and endoscopic contact laser lithotripsy controlled in oral transpapillary cholangioscopy with FiberLase U2. A 50-yo patient was admitted with clinical signs of chronic calculous pancreatitis and a history of EPST, pancreatic ductotomy and plastic pancreatic stenting. The first endoscopy stage comprised the encrusted pancreatic stent removal, retrograde pancreaticography, pancreatic ductotomy, narrowed terminal Wirsung’s duct bougienage with mechanical dilators and additional balloon-assisted dilation of the excision area and pancreatic stricture. Mechanical intraductal lithotripsy was unsuccessful. Contact lithotripsy with a novel superpulsed fibre thulium laser has been rendered. The technique presented ensures a complete sanation of the duct at no mucosal damage.Conclusion. We present the fully successful first national and world experience of the superpulsed fibre thulium laser application in contact lithotripsy of large calculi in common bile and main pancreatic ducts